Influence of estradiol on neurons of nucleus basomedialis in the amygdaloid complex of female rats
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The amygdaloid complex (AC) of rat brain is sensitive to sex steroids, especially during neonatal development. The aim of this investigation was to determine possible changes in neuron morphology of the basomedial nucleus (BMN) of the AC in female rats treated with estradiol. Two straining techniques were used: (1) standard histological staining with hematoxylin-eosin and (2) the Golgi method. Three types of neurons: pyramidal, fusiform and stellate were subjected to stereologic analaysis. Estradiol significantly increased the volume of neuronal soma of all three neuronal types at 16 and 90 days of age, whereas at day 38 changes were observed only in fusiform and stellate neurons. In addition, the volume of cell nuclei was increased but the number of neurons per unit area decreased at all experimental intervals examined. Therefore, estradiol causes stereologically detectable changes in the size and number of neurons in BMN AC.
Keywords:estradiol / basomedial nucleus / amygdaloid complex
Source:Acta veterinaria - Beograd, 1999, 49, 4, 231-238
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd