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dc.creatorĐurić, Ana
dc.creatorBegić, Aida
dc.creatorGobeljić, Borko
dc.creatorStanojević, Ivan
dc.creatorNinković, Milica
dc.creatorVojvodić, Danilo
dc.creatorPantelić, Ana
dc.creatorZebić, Goran
dc.creatorProkić, Vera
dc.creatorDejanović, Bratislav
dc.creatorStojanović, Ivana
dc.creatorPavlica, Marina
dc.creatorĐukić, Dusan
dc.creatorSaso, Luciano
dc.creatorĐurđević, Dragan
dc.creatorPavlović, Miloš
dc.creatorTopić, Aleksandra
dc.creatorVujanović, Dragana
dc.creatorStevanović, Ivana
dc.creatorĐukić, Mirjana
dc.date.accessioned2020-06-03T14:02:31Z
dc.date.available2020-06-03T14:02:31Z
dc.date.issued2015
dc.identifier.issn0278-6915
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1302
dc.description.abstractThe objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.relationMinistry of Defense of the Republic of Serbia [MFVMA/3/13-15, MFVMA/6/12-15]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectCadmiumen
dc.subjectOxidative stressen
dc.subjectBio-metalsen
dc.subjectTestosteroneen
dc.subjectTesticular toxicityen
dc.titleOxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmiumen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтевановић, Ивана; Ђурић, Aна; Павловић, Милош; Ђурђевић, Драган; Станојевић, Иван; Војводић, Данило; Гобељић, Борко; Топић, Aлександра; Зебић, Горан; Прокић, Вера; Дејановић, Братислав; Стојановић, Ивана; Павлица, Марина; Ђукић, Дусан; Вујановић, Драгана; Бегић, Aида; Нинковић, Милица; Сасо, Луциано; Ђукић, Мирјана; Пантелић, Aна;
dc.citation.volume86
dc.citation.spage25
dc.citation.epage33
dc.citation.other86: 25-33
dc.citation.rankM21
dc.identifier.wos000368203200004
dc.identifier.doi10.1016/j.fct.2015.09.004
dc.identifier.pmid26385724
dc.identifier.scopus2-s2.0-84942583403
dc.identifier.rcubconv_2127
dc.type.versionpublishedVersion


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