Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis
Апстракт
The paper presents clinical diagnostic approaches and therapeutic effects of a specific protocol for the treatment of dogs with cardiovascular dirofilariasis in the Belgrade City (Serbia) territory. The study involved 50 privately owned dogs of different breeds, gender, and age, all showing signs of cardio respiratory disorders. In addition to a general physical examination, blood tests were done to detect microfilaria and adult forms, and X-ray, ECG, and echocardiography were performed as well. At the first examination, 34 out of 50 examined dogs were positive for microfilaria and adult forms. Because of a lack of drug used as the golden standard in dirofilariasis treatment, it involved a combination of doxycycline (10 mg/kg) and ivermectin (6 mu g/kg) supported with Advocate Bayer spot-on. After six months, the first control was performed while continuing treatment with the aforesaid protocol, and the second control was performed after 12 months. Of the 34 treated dogs, all were nega...tive for microfilaria, as early as after the first six months of the treatment (100%). One dog was positive for adult forms of the parasite after six and 12 months. In echocardiography and X-ray examination after 12 months, six dogs showed evident chronic changes. At controls conducted at sixth month and at one year, the implemented therapy was successful in 97.05% (33/34) of primarily infected dogs.
Кључне речи:
dog / cardiovascular dirofilariasis / Dirofilaria immitis / drug therapyИзвор:
Bulletin of The Veterinary Institute in Pulawy, 2015, 59, 4, 505-509Издавач:
- Natl Veterinary Research Inst, Pulawy
Финансирање / пројекти:
- Праћење здравственог стања дивљачи и увођење нових биотехнолошких поступака у детекцији заразних и зоонозних агенаса - анализа ризика за здравље људи, домаћих и дивљих животиња и контаминацију животне средине (RS-31084)
- Примена EIIP/ISM биоинформатичке платформе у откривању нових терапеутских таргета и потенцијалних терапеутских молекула (RS-173001)
DOI: 10.1515/bvip-2015-0075
ISSN: 0042-4870
WoS: 000367114700012
Scopus: 2-s2.0-84955145100
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Stepanović, Predrag AU - Ilić, Tamara AU - Krstić, Nikola AU - Dimitrijević, Sanda PY - 2015 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1306 AB - The paper presents clinical diagnostic approaches and therapeutic effects of a specific protocol for the treatment of dogs with cardiovascular dirofilariasis in the Belgrade City (Serbia) territory. The study involved 50 privately owned dogs of different breeds, gender, and age, all showing signs of cardio respiratory disorders. In addition to a general physical examination, blood tests were done to detect microfilaria and adult forms, and X-ray, ECG, and echocardiography were performed as well. At the first examination, 34 out of 50 examined dogs were positive for microfilaria and adult forms. Because of a lack of drug used as the golden standard in dirofilariasis treatment, it involved a combination of doxycycline (10 mg/kg) and ivermectin (6 mu g/kg) supported with Advocate Bayer spot-on. After six months, the first control was performed while continuing treatment with the aforesaid protocol, and the second control was performed after 12 months. Of the 34 treated dogs, all were negative for microfilaria, as early as after the first six months of the treatment (100%). One dog was positive for adult forms of the parasite after six and 12 months. In echocardiography and X-ray examination after 12 months, six dogs showed evident chronic changes. At controls conducted at sixth month and at one year, the implemented therapy was successful in 97.05% (33/34) of primarily infected dogs. PB - Natl Veterinary Research Inst, Pulawy T2 - Bulletin of The Veterinary Institute in Pulawy T1 - Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis VL - 59 IS - 4 SP - 505 EP - 509 DO - 10.1515/bvip-2015-0075 ER -
@article{ author = "Stepanović, Predrag and Ilić, Tamara and Krstić, Nikola and Dimitrijević, Sanda", year = "2015", abstract = "The paper presents clinical diagnostic approaches and therapeutic effects of a specific protocol for the treatment of dogs with cardiovascular dirofilariasis in the Belgrade City (Serbia) territory. The study involved 50 privately owned dogs of different breeds, gender, and age, all showing signs of cardio respiratory disorders. In addition to a general physical examination, blood tests were done to detect microfilaria and adult forms, and X-ray, ECG, and echocardiography were performed as well. At the first examination, 34 out of 50 examined dogs were positive for microfilaria and adult forms. Because of a lack of drug used as the golden standard in dirofilariasis treatment, it involved a combination of doxycycline (10 mg/kg) and ivermectin (6 mu g/kg) supported with Advocate Bayer spot-on. After six months, the first control was performed while continuing treatment with the aforesaid protocol, and the second control was performed after 12 months. Of the 34 treated dogs, all were negative for microfilaria, as early as after the first six months of the treatment (100%). One dog was positive for adult forms of the parasite after six and 12 months. In echocardiography and X-ray examination after 12 months, six dogs showed evident chronic changes. At controls conducted at sixth month and at one year, the implemented therapy was successful in 97.05% (33/34) of primarily infected dogs.", publisher = "Natl Veterinary Research Inst, Pulawy", journal = "Bulletin of The Veterinary Institute in Pulawy", title = "Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis", volume = "59", number = "4", pages = "505-509", doi = "10.1515/bvip-2015-0075" }
Stepanović, P., Ilić, T., Krstić, N.,& Dimitrijević, S.. (2015). Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis. in Bulletin of The Veterinary Institute in Pulawy Natl Veterinary Research Inst, Pulawy., 59(4), 505-509. https://doi.org/10.1515/bvip-2015-0075
Stepanović P, Ilić T, Krstić N, Dimitrijević S. Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis. in Bulletin of The Veterinary Institute in Pulawy. 2015;59(4):505-509. doi:10.1515/bvip-2015-0075 .
Stepanović, Predrag, Ilić, Tamara, Krstić, Nikola, Dimitrijević, Sanda, "Efficiency of modified therapeutic protocol in the treatment of some varieties of canine cardiovascular dirofilariasis" in Bulletin of The Veterinary Institute in Pulawy, 59, no. 4 (2015):505-509, https://doi.org/10.1515/bvip-2015-0075 . .