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dc.creatorIvanović, Saša
dc.creatorDimitrijević, Blagoje
dc.creatorĆupić, Vitomir
dc.creatorJezdimirović, Milanka
dc.creatorBorozan, Sunčica
dc.creatorSavić, Mila
dc.creatorSavić, Đorđe
dc.date.accessioned2020-06-03T14:05:41Z
dc.date.available2020-06-03T14:05:41Z
dc.date.issued2016
dc.identifier.issn2214-7500
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/1347
dc.description.abstractDiazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetyl cholinesterase enzyme (AChE). In this work, we studied the development of tolerance to subchronic p.o. administration of DZN in rats, under both in vivo and in vitro conditions. A group of 20 rats (2 groups, n = 10) was administered p.o. the 1/10 of established LD50 DZN (namely 55.87 mg/kg bw) for 28 days. On the 14th and 28th day of study with isolated diaphragm and ileum, we examined the downregulation of nicotinic and muscarinic receptor function through Electrical Field Stimulation (EFS). Maximum contractility of the diaphragm was recorded on the 14th day of the study (25% higher compared to the non-treated rats), while on the 28th day the contractions almost did not differ from the values found in non-treated rats. EFS of isolated ileum on the 14th day of study caused significantly higher contractions compared to the non treated rats, but after 28 days, ileum contractions decreased approximately to the level of contractions in non-treated rats. On the 14th study day, we also recorded increased amplitude of spontaneous ileum contractions, compared to non-treated rats. The application of increasing ACh concentrations caused dose-dependent ileum contractions, without statistically significant differences of median effective concentration (EC50) values in non-treated and treated rats. Tolerance to subchronic DZN administration develops due to various adaptation mechanisms, including the most important one downregulation of nicotinic and muscarinic receptor function.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31085/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31087/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceToxicology Reports
dc.subjectDiazinonen
dc.subjectSubchronic intoxicationen
dc.subjectEFSen
dc.subjectDiaphragmen
dc.subjectIleumen
dc.subjectRatsen
dc.titleDownregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinonen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСавић, Мила; Савић, Ђорђе; Јездимировић, Миланка; Ћупић, Витомир; Борозан, Сунчица; Ивановић, Саша; Димитријевић, Благоје;
dc.citation.volume3
dc.citation.spage523
dc.citation.epage530
dc.citation.other3: 523-530
dc.identifier.wos000399044300061
dc.identifier.doi10.1016/j.toxrep.2016.06.002
dc.identifier.pmid28959576
dc.identifier.scopus2-s2.0-84975508604
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/314/1346.pdf
dc.type.versionpublishedVersion


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