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dc.creatorŽugić, Ana R.
dc.creatorLunter, Dominique Jasmin
dc.creatorDaniels, Rolf
dc.creatorPantelić, Ivana
dc.creatorTasic-Kostov, Marija
dc.creatorTadić, Vanja M.
dc.creatorMišić, Dušan
dc.creatorArsić, Ivana
dc.creatorSavić, Snežana
dc.date.accessioned2020-06-03T14:08:41Z
dc.date.available2020-06-03T14:08:41Z
dc.date.issued2016
dc.identifier.issn1083-7450
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1390
dc.description.abstractTopical treatment of skin infections is often limited by drawbacks related to both antimicrobial agents and their vehicles. In addition, considering the growing promotion of natural therapeutic products, our objective was to develop and evaluate naturally-based emulsion system, as prospective topical formulation for skin infections-treatment. Therefore, alkyl polyglucoside surfactants were used for stabilization of a vehicle serving as potential carrier for supercritical CO2-extract of Usnea barbata, lichen with well-documented antimicrobial activity, incorporated using two protocols and three concentrations. Comprehensive physicochemical characterization suggested possible involvement of extracts particles in stabilization of the investigated system. Raman spectral imaging served as the key method in disclosing extracts particles potential to participate in the microstructure of the tested emulsion system via three mechanisms: (1) particle-particle aggregation, (2) adsorption at the oil-water interface and (3) hydrophobic particle-surfactant interactions. Stated extract-vehicle interaction proved to be correlated to the preparation procedure and extract concentration on one hand and to affect the physicochemical and biopharmaceutical features of investigated system, on the other hand. Thereafter, formulation with the best preliminary stability and liberation profile was selected for further efficiency and in vivo skin irritation potential evaluation, implying pertinent in vitro antimicrobial activity against G+ bacteria and overall satisfying preliminary safety profile.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationGerman Academic Exchange Service Grant [A/11/84475]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourcePharmaceutical Development and Technology
dc.subjectAntimicrobial activityen
dc.subjectbiopharmaceutical characterizationen
dc.subjectcolloidal structureen
dc.subjectextract-vehicle interactionen
dc.subjectphysicochemical stabilityen
dc.subjectskin performanceen
dc.titleUsnea barbata CO2-supercritical extract in alkyl polyglucoside-based emulsion system: contribution of Confocal Raman imaging to the formulation development of a natural producten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМишић, Душан; Савић, Снежана; Даниелс, Ролф; Лунтер, Доминиqуе Јасмин; Aрсић, Ивана; Тадић, Вања М.; Пантелић, Ивана; Тасиц-Костов, Марија; Жугић, Aна Р.;
dc.citation.volume21
dc.citation.issue5
dc.citation.spage563
dc.citation.epage575
dc.citation.other21(5): 563-575
dc.citation.rankM23
dc.identifier.wos000375462900006
dc.identifier.doi10.3109/10837450.2015.1026606
dc.identifier.pmid26135231
dc.identifier.scopus2-s2.0-84969244162
dc.identifier.rcubconv_2150
dc.type.versionpublishedVersion


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