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First insights into the genetic diversity of Echinococcus granulosus sensu stricto (s.s.) in Serbia

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2016
Authors
Debeljak, Zoran
Boufana, Belgees
Interisano, Maria
Vidanović, Dejan
Kulišić, Zoran
Casulli, Adriano
Article (Published version)
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Abstract
Cystic echinococcosis (CE) caused by Echinococcus granulosus sensu stricto (s.s.) is a cosmopolitan zoonotic infection which is endemic in Serbia where it is subject to mandatory reporting. However, information on the incidence of the disease in humans and prevalence of hydatid infection in livestock remains limited. We used sequenced data of the cytochrome c oxidase subunit 1 (cox 1) mitochondrial gene to examine the genetic diversity and population structure of E. granulosus (s.s.) from intermediate hosts from Serbia. We also compared our generated nucleotide sequences with those reported for neighbouring European countries. Echinococcus canadensis was molecularly confirmed from pig and human hydatid isolates. E. granulosus (G1) was confirmed from sheep and cattle hydatid isolates as well as the first molecular confirmation in Serbia of E. granulosus G2 in sheep and E. granulosus G3 in sheep and cattle hydatid isolates. The Serbian E. granulosus (s.s.) parsimony network displayed 2 m...ain haplotypes (SB02 and SB05) which together with the neutrality indices were suggestive of bottleneck and/or balancing selection. Haplotype analysis showed the presence of the common E. granulosus haplotype described from other worldwide regions. Investigation of the pairwise fixation (Fst) index suggested that Serbian populations of E. granulosus (s.s.) from sheep and cattle hosts showed moderate genetic differentiation. Six of the Serbian haplotypes (SB02-SB07) were shared with haplotypes from Bulgaria, Hungary and/or Romania. Further studies using a larger number of hydatid isolates from various locations across Serbia will provide more information on the genetic structure of E. granulosus (s.s.) within this region.

Keywords:
Echinococcus granulosus sensu stricto / Genetic diversity / Serbia
Source:
Veterinary Parasitology, 2016, 223, 57-62
Publisher:
  • Elsevier Science Bv, Amsterdam
Projects:
  • Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies (EU-602051)

DOI: 10.1016/j.vetpar.2016.04.007

ISSN: 0304-4017

PubMed: 27198778

WoS: 000377317200011

Scopus: 2-s2.0-84963894030
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URI
http://vet-erinar.vet.bg.ac.rs/handle/123456789/1404
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  • Radovi istraživača / Researcher's publications
Institution
Fakultet veterinarske medicine

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