N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes
2016
Authors
Krstić, MilenaSovilj, Sofija P.
Borozan, Sunčica
Rancić, Milica
Poljarević, Jelena
Grgurić-Šipka, Sanja
Article (Published version)
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Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiaz...ines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.
Keywords:
N-alkylphenothiazines / antipsychotic drugs / anticancer / antibacterialSource:
Hemijska Industrija, 2016, 70, 4, 461-471Publisher:
- Savez hemijskih inženjera, Beograd
Funding / projects:
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-MESTD-Basic Research (BR or ON)-172014)
DOI: 10.2298/HEMIND150331052K
ISSN: 0367-598X
WoS: 000388029400011
Scopus: 2-s2.0-84992143985
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Fakultet veterinarske medicineTY - JOUR AU - Krstić, Milena AU - Sovilj, Sofija P. AU - Borozan, Sunčica AU - Rancić, Milica AU - Poljarević, Jelena AU - Grgurić-Šipka, Sanja PY - 2016 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1424 AB - Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects. PB - Savez hemijskih inženjera, Beograd T2 - Hemijska Industrija T1 - N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes VL - 70 IS - 4 SP - 461 EP - 471 DO - 10.2298/HEMIND150331052K ER -
@article{ author = "Krstić, Milena and Sovilj, Sofija P. and Borozan, Sunčica and Rancić, Milica and Poljarević, Jelena and Grgurić-Šipka, Sanja", year = "2016", abstract = "Phenothiazines are a large group of heterocyclic, aromatic molecules with nitrogen and sulphur between two benzene rings. Their derivatives, N-alkylphenothiazines have substituent on heterocyclic nitrogen atom which gives them different properties. Also, a series of these molecules have substitution on carbon atom at place 2 of phenothiazine benzene ring. Alkylphenothiazines contain aminoalkyl substituent and their alkyl, acyl and sulphonil derivatives, as well as monocyclic and bicyclic heterocycles attached at thiazine nitrogen atom or directly linked to benzene ring. The N-alkylphenothiazines have been known as antipsychotic drugs, but they also possess antibacterial, antifungal, anticancer activity, and ability to react with macromolecules and to coordinate to the metals. Metal complexes with N-alkylphenothiazines are biological active compounds with different antimicrobial activities and cytotoxic effect against tumor cell lines. The large field of application of N-alkylphenothiazines is very attractive in terms of synthesis of new related derivatives, metal complexes, studying their properties and applications. This article presents a review of the literature and a contemporary view at N-alkylphenothiazines - their synthesis and application, as well as their metal complexes which have promising biological effects.", publisher = "Savez hemijskih inženjera, Beograd", journal = "Hemijska Industrija", title = "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes", volume = "70", number = "4", pages = "461-471", doi = "10.2298/HEMIND150331052K" }
Krstić, M., Sovilj, S. P., Borozan, S., Rancić, M., Poljarević, J.,& Grgurić-Šipka, S.. (2016). N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija Savez hemijskih inženjera, Beograd., 70(4), 461-471. https://doi.org/10.2298/HEMIND150331052K
Krstić M, Sovilj SP, Borozan S, Rancić M, Poljarević J, Grgurić-Šipka S. N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes. in Hemijska Industrija. 2016;70(4):461-471. doi:10.2298/HEMIND150331052K .
Krstić, Milena, Sovilj, Sofija P., Borozan, Sunčica, Rancić, Milica, Poljarević, Jelena, Grgurić-Šipka, Sanja, "N-alkylphenothiazines - synthesis, structure and application as ligands in metal complexes" in Hemijska Industrija, 70, no. 4 (2016):461-471, https://doi.org/10.2298/HEMIND150331052K . .