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dc.creatorDejanović, Bratislav
dc.creatorStevanović, Ivana
dc.creatorNinković, Milica
dc.creatorStojanović, Ivana
dc.creatorLavrnja, Irena
dc.creatorRadičević, Tatjana
dc.creatorPavlović, Miloš
dc.date.accessioned2020-06-03T14:11:32Z
dc.date.available2020-06-03T14:11:32Z
dc.date.issued2016
dc.identifier.issn1229-845X
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1430
dc.description.abstractThis study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ and AGM (75 mg/kg BW). The control group was treated with 0.9% saline solution in the same manner. All tested compounds were administered i.p. in a single dose. Rats were sacrificed by decapitation 48 h after treatment Treatment with AGM significantly attenuated the oxidative stress parameters and restored antioxidant capacity in the forebrain cortex. The data indicated that i.p. administered AGM exerted antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes and microglia may contribute to secondary nerve-cell damage and participate in the balance of destructive vs. protective actions involved in the pathogenesis after poisoning.en
dc.publisherKorean Soc Veterinary Science, Seoul
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//
dc.relationMilitary Medical Academy [MBMA/3/13-15, MBMA/6/15-17]
dc.rightsopenAccess
dc.sourceJournal of Veterinary Science
dc.subjectagmatineen
dc.subjectantioxidant defenseen
dc.subjectastrocytesen
dc.subjectchlorpromazineen
dc.subjectoxidative stressen
dc.titleAgmatine protection against chlorpromazine-induced forebrain cortex injury in ratsen
dc.typearticle
dc.rights.licenseBY-NC-SA
dcterms.abstractПавловић, Милош; Дејановић, Братислав; Стевановић, Ивана; Нинковић, Милица; Стојановић, Ивана; Лаврња, Ирена; Радичевић, Татјана;
dc.citation.volume17
dc.citation.issue1
dc.citation.spage53
dc.citation.epage61
dc.citation.other17(1): 53-61
dc.citation.rankM22
dc.identifier.wos000373246900007
dc.identifier.doi10.4142/jvs.2016.17.1.53
dc.identifier.pmid27051340
dc.identifier.scopus2-s2.0-84962704615
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/393/1429.pdf
dc.identifier.rcubconv_2135
dc.type.versionpublishedVersion


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