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Pregled savremenih saznanja o razvoju subjediničnih i rekombinantnih vakcina protiv virusa Newcastle bolesti živine

dc.creatorMilić, Nenad
dc.creatorNišavić, Jakov
dc.creatorZorić, Andrea
dc.creatorKrnjaić, Dejan
dc.creatorRadojičić, Marina
dc.creatorStanojković, Aleksandar
dc.date.accessioned2020-06-03T14:13:08Z
dc.date.available2020-06-03T14:13:08Z
dc.date.issued2017
dc.identifier.issn1450-9156
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1453
dc.description.abstractNewcastle disease virus (NDV) is one of the most important viral pathogens of avian species and the causative agent of atypical fowl plague, a highly contagious and economically important disease characterized by high mortality rates and reduction of egg production. The HN and F proteins are the main targets for immune response to NDV. Vaccination of poultry with live and inactivated NDV vaccines is the most effective method of control and prevention of Newcastle disease, however due to their disadvantages, efforts are being invested into developing subunit vaccines. To this end, the NDV HN and/or F protein have been expressed using different viruses as vectors, but have also been expressed using transgenic plant systems, yeast and lactic acid bacteria in order to produce the NDV subunit vaccine. Many authors have investigated the possibility of preparation of vaccines from purified and biologically active NDV subunits with HN and F glycoproteins, purified from nucleocapsids, viral ribonucleic acid (RNA) and pyrogens. The above mentioned viral glycoproteins with preserved antigenic structure and biological activities can be used as subunit vaccinal antigens due to their immunogenic properties.en
dc.description.abstractVirus Newcastle bolesti je jedan od najznačajnijih patogena u populaciji ptica i domaće živine koji izaziva atipičnu kugu živine, kontagiozno oboljenje koje prati visoka stopa morbiditeta i mortaliteta, što ima za posledicu i velike ekonomske gubitke u živinarstvu. Glikoproteinski HN i F antigeni virusa atipične kuge živine su najznačajniji prilikom razvoja imunološkog odgovora prijemčivih jedinki. Vakcinacija živine živim i inaktivisanim vakcinama protiv virusa Newcastle bolesti predstavlja najefikasniji metod kontrole i prevencije navedenog oboljenja, međutim klasične vakcine imaju izvesne nedostatke i iz tog razloga se sve više istraživanja se usmerava na razvoj subjediničnih vakcina. U cilju razvoja subjediničnih vakcina u današnje vreme se za ekspresiju HN i F proteina virusa Newcastle bolesti koriste različiti vektori kao što su virusi, transgene biljke, kvasci i mlečnokiselinske bakterije. Pored toga, mnogi autori su ispitivali mogućnosti pripremanja subjediničnih vakcina od prečišćenih i biološki aktivnih subjedinica, odnosno HN i F glikoproteina pomenutog virusa, oslobođenih od nukleokapsida sa virusnom ribonukleinskom kiselinom (RNK) i pirogena. Virusni glikoproteini sa očuvanom antigenskom strukturom i biološkim aktivnostima se zbog svojih imunogenih svojstava mogu koristiti kao subjedinični vakcinalni antigeni.sr
dc.publisherInstitut za stočarstvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31008/RS//
dc.rightsopenAccess
dc.sourceBiotechnology in Animal Husbandry
dc.subjectNDVen
dc.subjectHNen
dc.subjectFen
dc.subjectsubunit vaccinesen
dc.subjectrecombinant vaccinesen
dc.subjectNDVsr
dc.subjectHNsr
dc.subjectFsr
dc.subjectsubjedinične vakcinesr
dc.subjectrekombinantne vaccinesr
dc.titleOverview of current advances in the development of subunit and recombinant vaccines against Newcastle disease virusen
dc.titlePregled savremenih saznanja o razvoju subjediničnih i rekombinantnih vakcina protiv virusa Newcastle bolesti živinesr
dc.typearticle
dc.rights.licenseBY
dcterms.abstractКрњаић, Дејан; Милић, Ненад; Нишавић, Јаков; Зорић, Aндреа; Радојичић, Марина; Станојковић, Aлександар;
dc.citation.volume33
dc.citation.issue1
dc.citation.spage1
dc.citation.epage11
dc.citation.other33(1): 1-11
dc.citation.rankM51
dc.identifier.doi10.2298/BAH1701001M
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/416/1452.pdf
dc.identifier.rcubconv_915
dc.type.versionpublishedVersion


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