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dc.creatorJokanović, Vukoman
dc.creatorColović, Bozana
dc.creatorMarković, Dejan
dc.creatorPetrović, Milan
dc.creatorSoldatović, Ivan
dc.creatorAntonijević, Đorđe
dc.creatorMilosavljević, Petar
dc.creatorSjerobabin, Nikola
dc.creatorSopta, Jelena
dc.date.accessioned2020-06-03T14:14:04Z
dc.date.available2020-06-03T14:14:04Z
dc.date.issued2017
dc.identifier.issn0013-5585
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1466
dc.description.abstractThis study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss (R), considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size. The evaluated parameters were: the presence of macrophages, giant cells, monoocytes, plasma cells, granulocytes, neo-angiogenesis, fibroplasia, and the percentage of mineralization. Parallel biofunctionality assays were performed using Geistlich Bio-Oss (R). The appearance of bone defects 12 weeks after the new scaffold implantation showed the presence of a small number of typical immune response cells. Furthermore, significantly reduced number of capillary buds, low intensity of fibroplasia and high degree of mineralization in a lamellar pattern indicated that the inflammation process has been almost completely overcome and that the new bone formed was in the final phase of remodeling. All biofunctionality assays proved the new scaffolds suitability as a bone substitute for applications in maxillofacial surgery. It showed numerous biological advantages over Geistlich Bio-Oss (R) which was reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.en
dc.publisherWalter De Gruyter Gmbh, Berlin
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceBiomedical Engineering-Biomedizinische Technik
dc.subjectbiofunctionalityen
dc.subjecthydroxyapatiteen
dc.subjectmineralizationen
dc.subjectnanotopologyen
dc.subjectPLGAen
dc.subjectscaffolden
dc.titleExtraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦоловић, Бозана; Милосављевић, Петар; Петровић, Милан; Марковић, Дејан; Јокановић, Вукоман; Сопта, Јелена; Солдатовић, Иван; Aнтонијевић, Ђорђе; Сјеробабин, Никола;
dc.citation.volume62
dc.citation.issue3
dc.citation.spage295
dc.citation.epage306
dc.citation.other62(3): 295-306
dc.citation.rankM23
dc.identifier.wos000403532700008
dc.identifier.doi10.1515/bmt-2015-0164
dc.identifier.pmid27285125
dc.identifier.scopus2-s2.0-85020445343
dc.identifier.rcubconv_2260
dc.type.versionpublishedVersion


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