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Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
dc.creator | Begić, Aida | |
dc.creator | Đurić, Ana | |
dc.creator | Ninković, Milica | |
dc.creator | Stevanović, Ivana | |
dc.creator | Đurđević, Dragan | |
dc.creator | Pavlović, Miloš | |
dc.creator | Jelić, Katarina | |
dc.creator | Pantelić, Ana | |
dc.creator | Zebić, Goran | |
dc.creator | Dejanović, Bratislav | |
dc.creator | Stanojević, Ivan | |
dc.creator | Vojvodić, Danilo | |
dc.creator | Milosavljević, Petar | |
dc.creator | Đukić, Mirjana | |
dc.creator | Saso, Luciano | |
dc.date.accessioned | 2020-06-03T14:16:14Z | |
dc.date.available | 2020-06-03T14:16:14Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1475-6366 | |
dc.identifier.uri | https://vet-erinar.vet.bg.ac.rs/handle/123456789/1496 | |
dc.description.abstract | Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS// | |
dc.relation | Ministry of Defence of the Republic of Serbia [MFVMA/3/13-15, MFVMA/6/12-15] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Journal of Enzyme Inhibition and Medicinal Chemistry | |
dc.subject | Cadmium | en |
dc.subject | disulfiram | en |
dc.subject | oxidative stress | en |
dc.subject | essential metals | en |
dc.subject | hepatotoxicity | en |
dc.title | Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Стевановић, Ивана; Пантелић, Aна; Ђурић, Aна; Сасо, Луциано; Војводић, Данило; Станојевић, Иван; Павловић, Милош; Ђурђевић, Драган; Јелић, Катарина; Ђукић, Мирјана; Нинковић, Милица; Зебић, Горан; Дејановић, Братислав; Бегић, Aида; Милосављевић, Петар; | |
dc.citation.volume | 32 | |
dc.citation.issue | 1 | |
dc.citation.spage | 478 | |
dc.citation.epage | 489 | |
dc.citation.other | 32(1): 478-489 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000392591100039 | |
dc.identifier.doi | 10.1080/14756366.2016.1261132 | |
dc.identifier.pmid | 28102089 | |
dc.identifier.scopus | 2-s2.0-85013790025 | |
dc.identifier.fulltext | https://vet-erinar.vet.bg.ac.rs/bitstream/id/457/1495.pdf | |
dc.type.version | publishedVersion |