Приказ основних података о документу

dc.creatorNešić, Slađan
dc.creatorKukolj, Vladimir
dc.creatorMarinković, Darko
dc.creatorVučićević, Ivana
dc.creatorJovanović, Milijan
dc.date.accessioned2020-06-03T14:17:05Z
dc.date.available2020-06-03T14:17:05Z
dc.date.issued2017
dc.identifier.issn0165-2176
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/1508
dc.description.abstractBackground: Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the wall of cerebral blood vessels. The deposits of amyloid occur frequently in the blood vessels of the frontal, parietal and occipital cortex. Objective: To examine the characteristics of CAA classified according to the Vonsattel scale in elderly dogs histologically and immunohistochemically as well as the semi-quantitative evaluation of the amyloid deposits in the different segments of the brain. Animals and methods: The brains of 36 dogs of different breeds and sexes, which had been routinely necropsied, were used and divided into two groups: dogs from 1 to 5 and 10 to 18 years old. The tissue sections were stained by hematoxylin-eosin, Congo red and immunohistochemically. Results: Amyloid was accumulated in the wall of cerebral blood vessels in 70% of dogs over the age of 10 years predominantly in the frontal cortex. CAA was demonstrated in elderly dogs as follows: in the frontal cortex (n=19 or 63%), the parietal cortex (n=12 or 40%), the hippocampus (40%) and the cerebellum (n=5 or 17%). The deposits of amyloid in the wall of blood vessels detected by Congo red staining were also A beta 1-14 and A beta 1-42 immunohistochemically positive. Most commonly, the amyloid deposits affected a moderate number of blood vessels. The accumulation of amyloid was immunohistochemically revealed in the blood vessel walls as well as in the senile plaques and neurons. Conclusion: The amount of amyloid in the arterial walls increased with age in dogs, whereas the amyloid accumulated in plaques was Congo red negative.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceVeterinary Quarterly
dc.subjectDogen
dc.subjectcanineen
dc.subjectbrainen
dc.subjectamyloiden
dc.subjectangiopathyen
dc.titleHistological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractКукољ, Владимир; Маринковић, Дарко; Нешић, Слађан; Вучићевић, Ивана; Јовановић, Милијан;
dc.citation.volume37
dc.citation.issue1
dc.citation.spage1
dc.citation.epage7
dc.citation.other37(1): 1-7
dc.citation.rankM21
dc.identifier.wos000399584500001
dc.identifier.doi10.1080/01652176.2016.1235301
dc.identifier.pmid27669976
dc.identifier.scopus2-s2.0-85028851512
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/469/1507.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу