Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs
Само за регистроване кориснике
2017
Аутори
Milanović, ZoranaBožović-Ilić, Anja
Francuski Andrić, Jelena
Radonjić, Vladimir
Beletić, Andelo
Kovačević-Filipović, Milica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B. canis (n = 13) and D. immitis (n = 18) and co-infected dogs (n = 7) were enrolled as well as healthy controls (n = 15). Routine haematology and biochemistry, agarose gel electrophoresis (agEF) protein fraction separation and enzyme-linked immtmosorbent assay (ELISA) for serum amyloid A (SAA) were performed. Based on clinical and laboratory findings, sepsis was diagnosed in the majority of dogs with acute B. cants infection with or without underlying asymptomatic D. immitis infe...ction. Overall, haematology, biochemistry and agEF pattern changes were induced and dictated by acute B. cards infection whether or not the dogs had an asymptomatic D. immitis infection. D. immitis infection slightly influenced the level of anaemia, slightly aggravated the level of dehydration and increased the concentration of gamma-globulins in acute-phase B. canis infection. D. immitis infection prevented B. canis-induced leukopenia. SAA equally increased in dogs with acute B. cans infection with or without underlying D. immitis infection. The level of SAA was not changed in dogs with asymptomatic D. immitis when compared to the controls. In conclusion, asymptomatic D. immitis infection does not influence overall APR after acute B. canis infection.
Кључне речи:
Protein electrophoresis / Serum amyloid A / Sepsis / Haematology / BiochemistryИзвор:
Ticks and Tick-Borne Diseases, 2017, 8, 6, 907-914Издавач:
- Elsevier Gmbh, Urban & Fischer Verlag, Jena
Финансирање / пројекти:
- Антиоксидативна заштита и потенцијали за диференцијацију и регенерацију мезенхималних матичних ћелија из различитих ткива током процеса старења (RS-MESTD-Basic Research (BR or ON)-175061)
DOI: 10.1016/j.ttbdis.2017.07.009
ISSN: 1877-959X
PubMed: 28802807
WoS: 000412378600014
Scopus: 2-s2.0-85027234689
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Milanović, Zorana AU - Božović-Ilić, Anja AU - Francuski Andrić, Jelena AU - Radonjić, Vladimir AU - Beletić, Andelo AU - Kovačević-Filipović, Milica PY - 2017 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1520 AB - Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B. canis (n = 13) and D. immitis (n = 18) and co-infected dogs (n = 7) were enrolled as well as healthy controls (n = 15). Routine haematology and biochemistry, agarose gel electrophoresis (agEF) protein fraction separation and enzyme-linked immtmosorbent assay (ELISA) for serum amyloid A (SAA) were performed. Based on clinical and laboratory findings, sepsis was diagnosed in the majority of dogs with acute B. cants infection with or without underlying asymptomatic D. immitis infection. Overall, haematology, biochemistry and agEF pattern changes were induced and dictated by acute B. cards infection whether or not the dogs had an asymptomatic D. immitis infection. D. immitis infection slightly influenced the level of anaemia, slightly aggravated the level of dehydration and increased the concentration of gamma-globulins in acute-phase B. canis infection. D. immitis infection prevented B. canis-induced leukopenia. SAA equally increased in dogs with acute B. cans infection with or without underlying D. immitis infection. The level of SAA was not changed in dogs with asymptomatic D. immitis when compared to the controls. In conclusion, asymptomatic D. immitis infection does not influence overall APR after acute B. canis infection. PB - Elsevier Gmbh, Urban & Fischer Verlag, Jena T2 - Ticks and Tick-Borne Diseases T1 - Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs VL - 8 IS - 6 SP - 907 EP - 914 DO - 10.1016/j.ttbdis.2017.07.009 ER -
@article{ author = "Milanović, Zorana and Božović-Ilić, Anja and Francuski Andrić, Jelena and Radonjić, Vladimir and Beletić, Andelo and Kovačević-Filipović, Milica", year = "2017", abstract = "Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B. canis (n = 13) and D. immitis (n = 18) and co-infected dogs (n = 7) were enrolled as well as healthy controls (n = 15). Routine haematology and biochemistry, agarose gel electrophoresis (agEF) protein fraction separation and enzyme-linked immtmosorbent assay (ELISA) for serum amyloid A (SAA) were performed. Based on clinical and laboratory findings, sepsis was diagnosed in the majority of dogs with acute B. cants infection with or without underlying asymptomatic D. immitis infection. Overall, haematology, biochemistry and agEF pattern changes were induced and dictated by acute B. cards infection whether or not the dogs had an asymptomatic D. immitis infection. D. immitis infection slightly influenced the level of anaemia, slightly aggravated the level of dehydration and increased the concentration of gamma-globulins in acute-phase B. canis infection. D. immitis infection prevented B. canis-induced leukopenia. SAA equally increased in dogs with acute B. cans infection with or without underlying D. immitis infection. The level of SAA was not changed in dogs with asymptomatic D. immitis when compared to the controls. In conclusion, asymptomatic D. immitis infection does not influence overall APR after acute B. canis infection.", publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena", journal = "Ticks and Tick-Borne Diseases", title = "Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs", volume = "8", number = "6", pages = "907-914", doi = "10.1016/j.ttbdis.2017.07.009" }
Milanović, Z., Božović-Ilić, A., Francuski Andrić, J., Radonjić, V., Beletić, A.,& Kovačević-Filipović, M.. (2017). Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs. in Ticks and Tick-Borne Diseases Elsevier Gmbh, Urban & Fischer Verlag, Jena., 8(6), 907-914. https://doi.org/10.1016/j.ttbdis.2017.07.009
Milanović Z, Božović-Ilić A, Francuski Andrić J, Radonjić V, Beletić A, Kovačević-Filipović M. Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs. in Ticks and Tick-Borne Diseases. 2017;8(6):907-914. doi:10.1016/j.ttbdis.2017.07.009 .
Milanović, Zorana, Božović-Ilić, Anja, Francuski Andrić, Jelena, Radonjić, Vladimir, Beletić, Andelo, Kovačević-Filipović, Milica, "Acute-phase response in Babesia canis and Dirofilaria immitis co-infections in dogs" in Ticks and Tick-Borne Diseases, 8, no. 6 (2017):907-914, https://doi.org/10.1016/j.ttbdis.2017.07.009 . .