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dc.creatorGlavinić, Uroš
dc.creatorStanković, Biljana
dc.creatorDrašković, Vladimir
dc.creatorStevanović, Jevrosima
dc.creatorPetrović, Tamaš
dc.creatorLakić, Nada
dc.creatorStanimirović, Zoran
dc.date.accessioned2020-06-03T14:19:24Z
dc.date.available2020-06-03T14:19:24Z
dc.date.issued2017
dc.identifier.issn1932-6203
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1541
dc.description.abstractMicrosporidium Nosema ceranae is well known for exerting a negative impact on honey bee health, including down-regulation of immunoregulatory genes. Protein nutrition has been proven to have beneficial effects on bee immunity and other aspects of bee health. Bearing this in mind, the aim of our study was to evaluate the potential of a dietary amino acid and vitamin complex BEEWELL AminoPlus to protect honey bees from immunosuppression induced by N. ceranae. In a laboratory experiment bees were infected with N. ceranae and treated with supplement on first, third, sixth and ninth day after emergence. The expression of genes for immune-related peptides (abaecin, apidaecin, hymenoptaecin, defensin and vitellogenin) was compared between groups. The results revealed significantly lower (p<0.01 or p<0.001) numbers of Nosema spores in supplemented groups than in the control especially on day 12 post infection. With the exception of abacein, the expression levels of immune-related peptides were significantly suppressed (p<0.01 or p<0.001) in control group on the 12th day post infection, compared to bees that received the supplement. It was supposed that N. ceranae had a negative impact on bee immunity and that the tested amino acid and vitamin complex modified the expression of immune-related genes in honey bees compromised by infection, suggesting immune-stimulation that reflects in the increase in resistance to diseases and reduced bee mortality. The supplement exerted best efficacy when applied simultaneously with Nosema infection, which can help us to assume the most suitable period for its application in the hive.en
dc.publisherPublic Library Science, San Francisco
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.rightsopenAccess
dc.sourcePLoS One
dc.titleDietary amino acid and vitamin complex protects honey bee from immunosuppression caused by Nosema ceranaeen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЛакић, Нада; Стевановић, Јевросима; Драшковић, Владимир; Петровић, Тамаш; Станимировић, Зоран; Главинић, Урош; Станковић, Биљана;
dc.citation.volume12
dc.citation.issue11
dc.citation.spagee0187726
dc.citation.other12(11): e0187726
dc.citation.rankM21
dc.identifier.wos000414659600069
dc.identifier.doi10.1371/journal.pone.0187726
dc.identifier.pmid29117233
dc.identifier.scopus2-s2.0-85033397871
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/505/1540.pdf
dc.identifier.rcubconv_2295
dc.type.versionpublishedVersion


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