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dc.creatorMarinković, Darko
dc.creatorAničić, Milan
dc.creatorVakanjac, Slobodanka
dc.creatorNedić, Svetlana
dc.creatorMagaš, Vladimir
dc.date.accessioned2020-06-03T14:22:53Z
dc.date.available2020-06-03T14:22:53Z
dc.date.issued2018
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1590
dc.description.abstractThe estrus cycle of bitches is divided into four phases: proestrus, estrus, diestrus and anestrus, during which different morphological changes, and also cyclic changes of estrogen and progesterone receptors are present. Several pathological changes can be differentiated on the endometrium, but one of these is the most important - cystic endometrial hyperplasia, which frequently develops into pyometra. The aim of the present study was to describe morphological characteristics, and expression of estrogen and progesterone receptors on the endometrium of mixed-breed bitches during the different phases of the estrus cycle, cystic endometrial hyperplasia and pyometra. The uterus and ovaries of 36 mixed breed bitches in different phases of the estrus cycle and also with cystic endometrial hyperplasia (CEH) and chronic purulent endometritis - pyometra were examined macroscopically, histopathologically, and immunohistochemically for estrogen receptors (ER) and progesterone receptors (PR). During proestrus uterine cells showed a weak reaction for both estrogen and progesterone receptors, but during estrus a large number of uterine cells showed a strong reaction on estrogen receptors and moderate reaction on progesterone receptors. On the contrary, during diestrus the scores for the estrogen receptors decreased, while the progesterone receptors level increased - uterine cells expressed strong reaction for progesterone receptors, and moderate reaction for estrogen receptors. Uterine cells in cystic endometrial hyperplasia expressed a strong reaction for estrogen receptors, and moderate reaction for progesterone receptors, but on the other hand the uterine cells in the uterus with pyometra expressed a moderate to strong reaction for progesterone receptors, and a weak reaction for estrogen receptors. In further investigations it would be interesting to perform quantitative analysis for both estrogen and progesterone receptors during different phases of the estrus cycle and also in the uterus with cystic endometrial hyperplasia and pyometra.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectbitchesen
dc.subjectuterusen
dc.subjectcystic endometrial hyperplasiaen
dc.subjectpyometraen
dc.subjectestrogen receptorsen
dc.subjectprogesterone receptorsen
dc.titleMorphological characteristics and expression of estrogen and progesterone receptors in the canine endometrium during the estrus cycle, cystic endometrial hyperplasia and pyometraen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНедић, Светлана; Маринковић, Дарко; Вакањац, Слободанка; Магаш, Владимир; Aничић, Милан;
dc.citation.volume68
dc.citation.issue3
dc.citation.spage239
dc.citation.epage250
dc.citation.other68(3): 239-250
dc.citation.rankM23
dc.identifier.wos000446384500001
dc.identifier.doi10.2478/acve-2018-0021
dc.identifier.scopus2-s2.0-85056197422
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/552/1589.pdf
dc.identifier.rcubconv_2418
dc.type.versionpublishedVersion


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