Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia
2018
Аутори
Aničić, MilanVučićević, Ivana
Vasković, Nikola
Radojičić, Sonja
Juntes, Polona
Nešić, Slađan
Aleksić-Kovačević, Sanja
Marinković, Darko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of ro...utine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.
Кључне речи:
brain / canine distemper virus / histopathology / immunohistochemistry / red foxИзвор:
Acta Veterinaria-Beograd, 2018, 68, 4, 434-444Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2478/acve-2018-0035
ISSN: 0567-8315
WoS: 000456859500005
Scopus: 2-s2.0-85060931502
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Aničić, Milan AU - Vučićević, Ivana AU - Vasković, Nikola AU - Radojičić, Sonja AU - Juntes, Polona AU - Nešić, Slađan AU - Aleksić-Kovačević, Sanja AU - Marinković, Darko PY - 2018 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1616 AB - Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia VL - 68 IS - 4 SP - 434 EP - 444 DO - 10.2478/acve-2018-0035 ER -
@article{ author = "Aničić, Milan and Vučićević, Ivana and Vasković, Nikola and Radojičić, Sonja and Juntes, Polona and Nešić, Slađan and Aleksić-Kovačević, Sanja and Marinković, Darko", year = "2018", abstract = "Canine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia", volume = "68", number = "4", pages = "434-444", doi = "10.2478/acve-2018-0035" }
Aničić, M., Vučićević, I., Vasković, N., Radojičić, S., Juntes, P., Nešić, S., Aleksić-Kovačević, S.,& Marinković, D.. (2018). Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(4), 434-444. https://doi.org/10.2478/acve-2018-0035
Aničić M, Vučićević I, Vasković N, Radojičić S, Juntes P, Nešić S, Aleksić-Kovačević S, Marinković D. Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia. in Acta Veterinaria-Beograd. 2018;68(4):434-444. doi:10.2478/acve-2018-0035 .
Aničić, Milan, Vučićević, Ivana, Vasković, Nikola, Radojičić, Sonja, Juntes, Polona, Nešić, Slađan, Aleksić-Kovačević, Sanja, Marinković, Darko, "Histopathological characteristics and expression of cdv-np antigen in the brain of serologically positive spontaneously infected red foxes (vulpes vulpes) in western Serbia" in Acta Veterinaria-Beograd, 68, no. 4 (2018):434-444, https://doi.org/10.2478/acve-2018-0035 . .