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dc.creatorDrašković, Vladimir
dc.creatorBošnjak-Neumuller, Jasna
dc.creatorVasiljević, Marko
dc.creatorPetrujkić, Branko
dc.creatorAleksić, Nevenka
dc.creatorKukolj, Vladimir
dc.creatorStanimirović, Zoran
dc.date.accessioned2020-06-03T14:26:10Z
dc.date.available2020-06-03T14:26:10Z
dc.date.issued2018
dc.identifier.issn0167-5877
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1636
dc.description.abstractLawsonia intracellularis is known to cause proliferative enteropathy (PE), one of the economically most important swine diseases with global distribution. Not unlike other enteric diseases, PE is a frequent indication for antibiotic therapy. However, their unjustified use leads to an emerging problem antimicrobial resistance. Thus, the aim of this research was to assess if a phytogenic additive may replace antibiotics in the control of PE in 144 weaned piglets (72 treated and 72 controls) naturally infected with L. intracellularis. The quantity of L intracellularis faecal shedding was monitored by real-time polymerase chain reaction (PCR) assay in faecal samples on day 0, 14 and 28, whilst the level of the ileum damage was determined by immunohistochemistry (IHC) assay performed on gut sections. Real-time PCR assay revealed that cycle-threshold (Ct) values in the treatment group increased significantly over time and were higher than in the control. These results indicate that the use of the phytogenic additive decreases the faecal excretion of L. intracellularis both throughout the experiment and in comparison to the control. The expression of the L. intracellularis antigen in IHC assay was lower in treated animals, implying that the additive leads to the decrease in the pathogen quantity in the ileum. Significantly higher feed conversion ratio was recorded in the treatment group. The results indicate that the phytogenic additive may be beneficial in the control of PE, but additional research is necessary to assess its use in various pig categories and define the optimum concentrations.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.rightsrestrictedAccess
dc.sourcePreventive Veterinary Medicine
dc.subjectLawsonia intracellularisen
dc.subjectProliferative enteropathyen
dc.subjectPhytogenic additiveen
dc.subjectPigen
dc.titleInfluence of phytogenic feed additive on Lawsonia intracellularis infection in pigsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанимировић, Зоран; Петрујкић, Бранко; Кукољ, Владимир; Васиљевић, Марко; Драшковић, Владимир; Бошњак-Неумуллер, Јасна; Aлексић, Невенка;
dc.citation.volume151
dc.citation.spage46
dc.citation.epage51
dc.citation.other151: 46-51
dc.citation.rankaM21
dc.identifier.wos000428098300007
dc.identifier.doi10.1016/j.prevetmed.2018.01.002
dc.identifier.pmid29496105
dc.identifier.scopus2-s2.0-85042927308
dc.identifier.rcubconv_2360
dc.type.versionpublishedVersion


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