Influence of cadmium chloride on the frequency of micronuclei in da and AO rats
2018
Authors
Popović-Bubujuk, SlavicaĐelić, Ninoslav
Muster, Adrian
Kataranovski, Dragan
Anđelković, Marko
Article (Published version)
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Show full item recordAbstract
Heavy metal cadmium (Cd), a well-known environmental hazard, exerts a number of toxic and genotoxic effects. Experimental animals, Albino Oxford (AO) and Dark August (DA) rat strains, were treated intraperitoneally with three different concentrations of cadmium chloride (CdCl2): 0.5, 1, and 2 mg CdCl2 per kg of body weight, while the control animals received equal volume of sterile phosphate buffered saline. In this investigation individuals of both sexes aged 3, 6 and 12 month were used. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after treatment. The results showed that that cadmium-cloride (CdCl2) exibits the genotoxic effects causing an increase of the frequency of micronuclei depending on concentration, sex, age and strain.
Keywords:
Albino Oxford / cadmium / Dark August / micronucleus / ratsSource:
Genetika, 2018, 50, 2, 705-716Publisher:
- Društvo genetičara Srbije, Beograd
Funding / projects:
- Molecular genetic and ecophysiological researches on the protection of autochthonous animal genetic resources, sustaining domestic animals’ welfare, health and reproduction, and safe food production (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
- Dynamics of gene pool, genetic and phenotypic variability of populations, determined by the environmental changes (RS-MESTD-Basic Research (BR or ON)-173012)
DOI: 10.2298/GENSR1802705P
ISSN: 0534-0012
WoS: 000442685800028
Scopus: 2-s2.0-85056234012
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Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Popović-Bubujuk, Slavica AU - Đelić, Ninoslav AU - Muster, Adrian AU - Kataranovski, Dragan AU - Anđelković, Marko PY - 2018 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1661 AB - Heavy metal cadmium (Cd), a well-known environmental hazard, exerts a number of toxic and genotoxic effects. Experimental animals, Albino Oxford (AO) and Dark August (DA) rat strains, were treated intraperitoneally with three different concentrations of cadmium chloride (CdCl2): 0.5, 1, and 2 mg CdCl2 per kg of body weight, while the control animals received equal volume of sterile phosphate buffered saline. In this investigation individuals of both sexes aged 3, 6 and 12 month were used. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after treatment. The results showed that that cadmium-cloride (CdCl2) exibits the genotoxic effects causing an increase of the frequency of micronuclei depending on concentration, sex, age and strain. PB - Društvo genetičara Srbije, Beograd T2 - Genetika T1 - Influence of cadmium chloride on the frequency of micronuclei in da and AO rats VL - 50 IS - 2 SP - 705 EP - 716 DO - 10.2298/GENSR1802705P ER -
@article{ author = "Popović-Bubujuk, Slavica and Đelić, Ninoslav and Muster, Adrian and Kataranovski, Dragan and Anđelković, Marko", year = "2018", abstract = "Heavy metal cadmium (Cd), a well-known environmental hazard, exerts a number of toxic and genotoxic effects. Experimental animals, Albino Oxford (AO) and Dark August (DA) rat strains, were treated intraperitoneally with three different concentrations of cadmium chloride (CdCl2): 0.5, 1, and 2 mg CdCl2 per kg of body weight, while the control animals received equal volume of sterile phosphate buffered saline. In this investigation individuals of both sexes aged 3, 6 and 12 month were used. Frequency of micronuclei formation was evaluated in polychromatic erythrocytes (PCEs), 24h hours after treatment. The results showed that that cadmium-cloride (CdCl2) exibits the genotoxic effects causing an increase of the frequency of micronuclei depending on concentration, sex, age and strain.", publisher = "Društvo genetičara Srbije, Beograd", journal = "Genetika", title = "Influence of cadmium chloride on the frequency of micronuclei in da and AO rats", volume = "50", number = "2", pages = "705-716", doi = "10.2298/GENSR1802705P" }
Popović-Bubujuk, S., Đelić, N., Muster, A., Kataranovski, D.,& Anđelković, M.. (2018). Influence of cadmium chloride on the frequency of micronuclei in da and AO rats. in Genetika Društvo genetičara Srbije, Beograd., 50(2), 705-716. https://doi.org/10.2298/GENSR1802705P
Popović-Bubujuk S, Đelić N, Muster A, Kataranovski D, Anđelković M. Influence of cadmium chloride on the frequency of micronuclei in da and AO rats. in Genetika. 2018;50(2):705-716. doi:10.2298/GENSR1802705P .
Popović-Bubujuk, Slavica, Đelić, Ninoslav, Muster, Adrian, Kataranovski, Dragan, Anđelković, Marko, "Influence of cadmium chloride on the frequency of micronuclei in da and AO rats" in Genetika, 50, no. 2 (2018):705-716, https://doi.org/10.2298/GENSR1802705P . .