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dc.creatorPavlović, Miloš
dc.creatorDurić, Ana
dc.creatorStevanović, Ivana
dc.creatorBegić, Aida
dc.creatorVujanović, Dragana
dc.creatorNinković, Milica
dc.creatorDukić, Mirjana
dc.date.accessioned2020-06-03T14:30:17Z
dc.date.available2020-06-03T14:30:17Z
dc.date.issued2019
dc.identifier.issn0354-4664
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1694
dc.description.abstractWe investigated the effect of disulfiram (DSF) on reproductive toxicity induced by subchronic exposure to cadmium (Cd). We examined the redox status and systemic testosterone changes in the testes and plasma of Cd-treated male Wistar rats. Rats were treated with 1 mg CdCl2/kg body weight (bw)/day (intraperitoneal administration) for 42 days; in the second experimental group, rats were given 178.5 mg DSF/kg bw/day by oral gavage for 21 days; in the third group, after administration of Cd for 21 days, DSF treatment was introduced on day 22 and lasted until day 42, with continuous Cd intake. Each experimental group had a matching control: untreated rats, rats that received for 21 days olive oil, the solvent for DSF; rats that started with olive oil intake from days 22-42. Exposure of rats to DSF modulated the oxidative status in the testes; thus, coexposure increased the Cd-induced reduction in total superoxide dismutase (tSOD), catalase ( CAT), glutathione reductase (GR) and total glutathione-S-transferase (tGST) activities, and lowered the Cd-increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) concentrations. DSF did not affect testosterone production diminished by Cd, as Leydig cells, once impaired by Cd, could not be reactivated by DSF.en
dc.publisherSrpsko biološko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.relationMedical Faculty of Military Medical Academy, University of Defense, Republic of Serbia [MFVMA/01/18-20]
dc.rightsopenAccess
dc.sourceArchives of Biological Sciences
dc.subjectcadmiumen
dc.subjectdisulfiramen
dc.subjectoxidative stressen
dc.subjecttestesen
dc.subjectraten
dc.titleDisulfiram partially improves oxidative but not androgen status in rats exposed to cadmiumen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractВујановић, Драгана; Стевановић, Ивана; Бегић, Aида; Дукић, Мирјана; Павловић, Милош; Нинковић, Милица; Дурић, Aна;
dc.citation.volume71
dc.citation.issue4
dc.citation.spage747
dc.citation.epage753
dc.citation.other71(4): 747-753
dc.citation.rankM23
dc.identifier.wos000505766800018
dc.identifier.doi10.2298/ABS190814057P
dc.identifier.scopus2-s2.0-85083273849
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/651/1693.pdf
dc.identifier.rcubconv_2546
dc.type.versionpublishedVersion


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