Chromosome aberrations produced by mestranol in human lymphocyte cultures
2019
Аутори
Teodorović, RadislavaDrašković, Vladimir
Đurić, Spomenka
Nenadović, Katarina
Mirilović, Milorad
Janković, Ljiljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the chemosterilant were assessed by numerical and structural chromosome aberrations. Mestranol induced certain genotoxic effects in human lymphocytes. There was a dose-dependent significant (p<0.01) increase in the number of numerical aberrations in comparison to the control, but without significant differences (p>0.05) between the doses applied. Further, structural aberrations increased significantly (p<0.01) in the presence of mestranol, being most frequent in cultures exposed to the highest mestranol dose. The frequency of Robertsonian translocations increased significantly only in cultures treated with mestranol at concentration of 30 mu g/g in comparison both with the control (p <0.01) and the lowest chemosterilant dose (p<0.01). There were significant differences (p<0....01) in the levels of chromosome gaps and fragments compared to Robertsonian translocations, whilst the frequencies between gaps and fragments were not significantly different (p>0.05).
Кључне речи:
mestranol / cytogenetics / genotoxicity / human lymphocytesИзвор:
Acta Veterinaria-Beograd, 2019, 69, 4, 426-433Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2478/acve-2019-0036
ISSN: 0567-8315
WoS: 000504081900006
Scopus: 2-s2.0-85078186815
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Teodorović, Radislava AU - Drašković, Vladimir AU - Đurić, Spomenka AU - Nenadović, Katarina AU - Mirilović, Milorad AU - Janković, Ljiljana PY - 2019 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1695 AB - In this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the chemosterilant were assessed by numerical and structural chromosome aberrations. Mestranol induced certain genotoxic effects in human lymphocytes. There was a dose-dependent significant (p<0.01) increase in the number of numerical aberrations in comparison to the control, but without significant differences (p>0.05) between the doses applied. Further, structural aberrations increased significantly (p<0.01) in the presence of mestranol, being most frequent in cultures exposed to the highest mestranol dose. The frequency of Robertsonian translocations increased significantly only in cultures treated with mestranol at concentration of 30 mu g/g in comparison both with the control (p <0.01) and the lowest chemosterilant dose (p<0.01). There were significant differences (p<0.01) in the levels of chromosome gaps and fragments compared to Robertsonian translocations, whilst the frequencies between gaps and fragments were not significantly different (p>0.05). PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Chromosome aberrations produced by mestranol in human lymphocyte cultures VL - 69 IS - 4 SP - 426 EP - 433 DO - 10.2478/acve-2019-0036 ER -
@article{ author = "Teodorović, Radislava and Drašković, Vladimir and Đurić, Spomenka and Nenadović, Katarina and Mirilović, Milorad and Janković, Ljiljana", year = "2019", abstract = "In this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the chemosterilant were assessed by numerical and structural chromosome aberrations. Mestranol induced certain genotoxic effects in human lymphocytes. There was a dose-dependent significant (p<0.01) increase in the number of numerical aberrations in comparison to the control, but without significant differences (p>0.05) between the doses applied. Further, structural aberrations increased significantly (p<0.01) in the presence of mestranol, being most frequent in cultures exposed to the highest mestranol dose. The frequency of Robertsonian translocations increased significantly only in cultures treated with mestranol at concentration of 30 mu g/g in comparison both with the control (p <0.01) and the lowest chemosterilant dose (p<0.01). There were significant differences (p<0.01) in the levels of chromosome gaps and fragments compared to Robertsonian translocations, whilst the frequencies between gaps and fragments were not significantly different (p>0.05).", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Chromosome aberrations produced by mestranol in human lymphocyte cultures", volume = "69", number = "4", pages = "426-433", doi = "10.2478/acve-2019-0036" }
Teodorović, R., Drašković, V., Đurić, S., Nenadović, K., Mirilović, M.,& Janković, L.. (2019). Chromosome aberrations produced by mestranol in human lymphocyte cultures. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 69(4), 426-433. https://doi.org/10.2478/acve-2019-0036
Teodorović R, Drašković V, Đurić S, Nenadović K, Mirilović M, Janković L. Chromosome aberrations produced by mestranol in human lymphocyte cultures. in Acta Veterinaria-Beograd. 2019;69(4):426-433. doi:10.2478/acve-2019-0036 .
Teodorović, Radislava, Drašković, Vladimir, Đurić, Spomenka, Nenadović, Katarina, Mirilović, Milorad, Janković, Ljiljana, "Chromosome aberrations produced by mestranol in human lymphocyte cultures" in Acta Veterinaria-Beograd, 69, no. 4 (2019):426-433, https://doi.org/10.2478/acve-2019-0036 . .