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dc.creatorTeodorović, Radislava
dc.creatorDrašković, Vladimir
dc.creatorĐurić, Spomenka
dc.creatorNenadović, Katarina
dc.creatorMirilović, Milorad
dc.creatorJanković, Ljiljana
dc.date.accessioned2020-06-03T14:30:21Z
dc.date.available2020-06-03T14:30:21Z
dc.date.issued2019
dc.identifier.issn0567-8315
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1695
dc.description.abstractIn this investigation, the genotoxic properties of mestranol were examined in vitro. Human lymphocyte cultures were exposed for 72 h to mestranol at concentrations of 7.5, 15 and 30 mu g/g. The genotoxic effects of the chemosterilant were assessed by numerical and structural chromosome aberrations. Mestranol induced certain genotoxic effects in human lymphocytes. There was a dose-dependent significant (p<0.01) increase in the number of numerical aberrations in comparison to the control, but without significant differences (p>0.05) between the doses applied. Further, structural aberrations increased significantly (p<0.01) in the presence of mestranol, being most frequent in cultures exposed to the highest mestranol dose. The frequency of Robertsonian translocations increased significantly only in cultures treated with mestranol at concentration of 30 mu g/g in comparison both with the control (p <0.01) and the lowest chemosterilant dose (p<0.01). There were significant differences (p<0.01) in the levels of chromosome gaps and fragments compared to Robertsonian translocations, whilst the frequencies between gaps and fragments were not significantly different (p>0.05).en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa veterinaria - Beograd
dc.subjectmestranolen
dc.subjectcytogeneticsen
dc.subjectgenotoxicityen
dc.subjecthuman lymphocytesen
dc.titleChromosome aberrations produced by mestranol in human lymphocyte culturesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНенадовић, Катарина; Теодоровић, Радислава; Драшковић, Владимир; Мириловић, Милорад; Ђурић, Споменка; Јанковић, Љиљана;
dc.citation.volume69
dc.citation.issue4
dc.citation.spage426
dc.citation.epage433
dc.citation.other69(4): 426-433
dc.citation.rankM23~
dc.identifier.wos000504081900006
dc.identifier.doi10.2478/acve-2019-0036
dc.identifier.scopus2-s2.0-85078186815
dc.identifier.fulltexthttp://veterinar.vet.bg.ac.rs/bitstream/id/652/1694.pdf
dc.identifier.rcubconv_2541
dc.type.versionpublishedVersion


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