Nephrosonographic examinations in dogs with gentamicin induced acute renal failure
Ultrazvučna ispitivanja promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom izazvanom gentamicinom
Apstrakt
In this study we investigated the feasibility of ultrasonography in the evaluation of renal parenchyma structural changes in dogs with acute renal failure (ARF) induced by high doses of gentamicin (40 mg/kg body mass, at 12hr intervals during 7 days). Acute renal failure was induced in all experimental animals after three days and the disease had a progressive tendency till the end of the experiment. Morphometric analyzes of the kidneys did not reveal changes in the size of the organ as compared to the values observed at the beginning of the study. Initial changes in the echostructure of the renal parenchyma were observed in 92% of the animals starting from day 3 of the experiment. They were manifested as enhanced echogenicity of the codex and a less prominent corticomedullar junction and these findings correlated with the onset of ARF. During the experiment, changes in the renal structure intensified and on day 9 marked hyperechoity of the codex and complete loss of the corticomedulla...r junction were observed in the majority of experimental animals. Our results confirmed the correlation between the changes in renal structure estimated by nephrosonography and the progress of ARF.
U ovom radu su vršena ispitivanja mogućnosti ultrazvučne dijagnostike promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom eksperimentalno izazvanom s.c. aplikacijom visokih doza gentamicina (40 mg/kg), dva puta dnevno, tokom sedam dana. Postojanje akutne bubrežne slabosti je dokazano kod svih oglednih životinja već 3. dana eksperimenta sa tendencijom progresije bolesti do kraja ogleda. Analizom rezultata morfo-metrijskih ispitivanja bubrega nisu utvrđene promene u veličini ovih organa tokom eksperimenta u odnosu na vrednosti izmerene 0. dana. Prisustvo inicijalnih promena u ehostrukturi bubrežnog parenhima u smislu povećanja ehogenosti korteksa i slabije diferencijacije kortiko-medulamog prelaza, kod većine pasa (11) ustanovljeno je 3. dana ogleda, što se podudara sa razvojem ARI. Tokom eksperimenta promené u bubrežnoj strukturi su se intenzivirale, tako da je 9. dana kod većine pasa ustanovljena izrazita hiperehogenost korteksa sa potpunim gubitkom kortiko-medularne ...granice. Ovi naši nalazi potvrđuju da postoji korelacija između rezultata dobijenih ehosonografskim ispitivanjima bubrega pasa i razvoja ARI.
Ključne reči:
acute renal failure / dog / gentamicin / ultrasonographyIzvor:
Acta Veterinaria-Beograd, 2001, 51, 2-3, 115-123Izdavač:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Kolekcije
Institucija/grupa
Fakultet veterinarske medicineTY - JOUR AU - Macanović, Mirjana AU - Janković-Zagorčić, Anica AU - Lišanin, Lj. AU - Dodić, M. AU - Spasić, V. PY - 2001 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/172 AB - In this study we investigated the feasibility of ultrasonography in the evaluation of renal parenchyma structural changes in dogs with acute renal failure (ARF) induced by high doses of gentamicin (40 mg/kg body mass, at 12hr intervals during 7 days). Acute renal failure was induced in all experimental animals after three days and the disease had a progressive tendency till the end of the experiment. Morphometric analyzes of the kidneys did not reveal changes in the size of the organ as compared to the values observed at the beginning of the study. Initial changes in the echostructure of the renal parenchyma were observed in 92% of the animals starting from day 3 of the experiment. They were manifested as enhanced echogenicity of the codex and a less prominent corticomedullar junction and these findings correlated with the onset of ARF. During the experiment, changes in the renal structure intensified and on day 9 marked hyperechoity of the codex and complete loss of the corticomedullar junction were observed in the majority of experimental animals. Our results confirmed the correlation between the changes in renal structure estimated by nephrosonography and the progress of ARF. AB - U ovom radu su vršena ispitivanja mogućnosti ultrazvučne dijagnostike promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom eksperimentalno izazvanom s.c. aplikacijom visokih doza gentamicina (40 mg/kg), dva puta dnevno, tokom sedam dana. Postojanje akutne bubrežne slabosti je dokazano kod svih oglednih životinja već 3. dana eksperimenta sa tendencijom progresije bolesti do kraja ogleda. Analizom rezultata morfo-metrijskih ispitivanja bubrega nisu utvrđene promene u veličini ovih organa tokom eksperimenta u odnosu na vrednosti izmerene 0. dana. Prisustvo inicijalnih promena u ehostrukturi bubrežnog parenhima u smislu povećanja ehogenosti korteksa i slabije diferencijacije kortiko-medulamog prelaza, kod većine pasa (11) ustanovljeno je 3. dana ogleda, što se podudara sa razvojem ARI. Tokom eksperimenta promené u bubrežnoj strukturi su se intenzivirale, tako da je 9. dana kod većine pasa ustanovljena izrazita hiperehogenost korteksa sa potpunim gubitkom kortiko-medularne granice. Ovi naši nalazi potvrđuju da postoji korelacija između rezultata dobijenih ehosonografskim ispitivanjima bubrega pasa i razvoja ARI. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Nephrosonographic examinations in dogs with gentamicin induced acute renal failure T1 - Ultrazvučna ispitivanja promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom izazvanom gentamicinom VL - 51 IS - 2-3 SP - 115 EP - 123 UR - https://hdl.handle.net/21.15107/rcub_veterinar_172 ER -
@article{ author = "Macanović, Mirjana and Janković-Zagorčić, Anica and Lišanin, Lj. and Dodić, M. and Spasić, V.", year = "2001", abstract = "In this study we investigated the feasibility of ultrasonography in the evaluation of renal parenchyma structural changes in dogs with acute renal failure (ARF) induced by high doses of gentamicin (40 mg/kg body mass, at 12hr intervals during 7 days). Acute renal failure was induced in all experimental animals after three days and the disease had a progressive tendency till the end of the experiment. Morphometric analyzes of the kidneys did not reveal changes in the size of the organ as compared to the values observed at the beginning of the study. Initial changes in the echostructure of the renal parenchyma were observed in 92% of the animals starting from day 3 of the experiment. They were manifested as enhanced echogenicity of the codex and a less prominent corticomedullar junction and these findings correlated with the onset of ARF. During the experiment, changes in the renal structure intensified and on day 9 marked hyperechoity of the codex and complete loss of the corticomedullar junction were observed in the majority of experimental animals. Our results confirmed the correlation between the changes in renal structure estimated by nephrosonography and the progress of ARF., U ovom radu su vršena ispitivanja mogućnosti ultrazvučne dijagnostike promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom eksperimentalno izazvanom s.c. aplikacijom visokih doza gentamicina (40 mg/kg), dva puta dnevno, tokom sedam dana. Postojanje akutne bubrežne slabosti je dokazano kod svih oglednih životinja već 3. dana eksperimenta sa tendencijom progresije bolesti do kraja ogleda. Analizom rezultata morfo-metrijskih ispitivanja bubrega nisu utvrđene promene u veličini ovih organa tokom eksperimenta u odnosu na vrednosti izmerene 0. dana. Prisustvo inicijalnih promena u ehostrukturi bubrežnog parenhima u smislu povećanja ehogenosti korteksa i slabije diferencijacije kortiko-medulamog prelaza, kod većine pasa (11) ustanovljeno je 3. dana ogleda, što se podudara sa razvojem ARI. Tokom eksperimenta promené u bubrežnoj strukturi su se intenzivirale, tako da je 9. dana kod većine pasa ustanovljena izrazita hiperehogenost korteksa sa potpunim gubitkom kortiko-medularne granice. Ovi naši nalazi potvrđuju da postoji korelacija između rezultata dobijenih ehosonografskim ispitivanjima bubrega pasa i razvoja ARI.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Nephrosonographic examinations in dogs with gentamicin induced acute renal failure, Ultrazvučna ispitivanja promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom izazvanom gentamicinom", volume = "51", number = "2-3", pages = "115-123", url = "https://hdl.handle.net/21.15107/rcub_veterinar_172" }
Macanović, M., Janković-Zagorčić, A., Lišanin, Lj., Dodić, M.,& Spasić, V.. (2001). Nephrosonographic examinations in dogs with gentamicin induced acute renal failure. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 51(2-3), 115-123. https://hdl.handle.net/21.15107/rcub_veterinar_172
Macanović M, Janković-Zagorčić A, Lišanin L, Dodić M, Spasić V. Nephrosonographic examinations in dogs with gentamicin induced acute renal failure. in Acta Veterinaria-Beograd. 2001;51(2-3):115-123. https://hdl.handle.net/21.15107/rcub_veterinar_172 .
Macanović, Mirjana, Janković-Zagorčić, Anica, Lišanin, Lj., Dodić, M., Spasić, V., "Nephrosonographic examinations in dogs with gentamicin induced acute renal failure" in Acta Veterinaria-Beograd, 51, no. 2-3 (2001):115-123, https://hdl.handle.net/21.15107/rcub_veterinar_172 .