Nephrosonographic examinations in dogs with gentamicin induced acute renal failure

Abstract

In this study we investigated the feasibility of ultrasonography in the evaluation of renal parenchyma structural changes in dogs with acute renal failure (ARF) induced by high doses of gentamicin (40 mg/kg body mass, at 12hr intervals during 7 days). Acute renal failure was induced in all experimental animals after three days and the disease had a progressive tendency till the end of the experiment. Morphometric analyzes of the kidneys did not reveal changes in the size of the organ as compared to the values observed at the beginning of the study. Initial changes in the echostructure of the renal parenchyma were observed in 92% of the animals starting from day 3 of the experiment. They were manifested as enhanced echogenicity of the codex and a less prominent corticomedullar junction and these findings correlated with the onset of ARF. During the experiment, changes in the renal structure intensified and on day 9 marked hyperechoity of the codex and complete loss of the corticomedullar junction were observed in the majority of experimental animals. Our results confirmed the correlation between the changes in renal structure estimated by nephrosonography and the progress of ARF.

U ovom radu su vršena ispitivanja mogućnosti ultrazvučne dijagnostike promena u parenhimu bubrega pasa sa akutnom renalnom insuficijencijom eksperimentalno izazvanom s.c. aplikacijom visokih doza gentamicina (40 mg/kg), dva puta dnevno, tokom sedam dana. Postojanje akutne bubrežne slabosti je dokazano kod svih oglednih životinja već 3. dana eksperimenta sa tendencijom progresije bolesti do kraja ogleda. Analizom rezultata morfo-metrijskih ispitivanja bubrega nisu utvrđene promene u veličini ovih organa tokom eksperimenta u odnosu na vrednosti izmerene 0. dana. Prisustvo inicijalnih promena u ehostrukturi bubrežnog parenhima u smislu povećanja ehogenosti korteksa i slabije diferencijacije kortiko-medulamog prelaza, kod većine pasa (11) ustanovljeno je 3. dana ogleda, što se podudara sa razvojem ARI. Tokom eksperimenta promené u bubrežnoj strukturi su se intenzivirale, tako da je 9. dana kod većine pasa ustanovljena izrazita hiperehogenost korteksa sa potpunim gubitkom kortiko-medularne granice. Ovi naši nalazi potvrđuju da postoji korelacija između rezultata dobijenih ehosonografskim ispitivanjima bubrega pasa i razvoja ARI.