Toxicity of high uranium doses in broilers and protection with mineral adsorbents
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2019
Authors
Mitrović, BranislavaStojanović, Mirjana
Sekulić, Zivko
Andrić, Velibor
Vićentijević, Mihajlo
Vranješ, Borjana
Article (Published version)
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Show full item recordAbstract
The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed th...e highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%).
Keywords:
Uranyl nitrate / Broilers / Toxicity / Histopathological changes / AdsorbentsSource:
Radiation and Environmental Biophysics, 2019, 58, 3, 385-391Publisher:
- Springer, New York
Funding / projects:
- Development of technologies and products based on mineral raw materials and waste biomass for protection of natural resources for safe food production (RS-MESTD-Technological Development (TD or TR)-31003)
- Development of technological processes for obtaining of ecological materials based on nonmetallic minerals (RS-MESTD-Technological Development (TD or TR)-34013)
DOI: 10.1007/s00411-019-00790-5
ISSN: 0301-634X
PubMed: 30972493
WoS: 000474439000007
Scopus: 2-s2.0-85068765195
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Fakultet veterinarske medicineTY - JOUR AU - Mitrović, Branislava AU - Stojanović, Mirjana AU - Sekulić, Zivko AU - Andrić, Velibor AU - Vićentijević, Mihajlo AU - Vranješ, Borjana PY - 2019 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1749 AB - The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed the highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%). PB - Springer, New York T2 - Radiation and Environmental Biophysics T1 - Toxicity of high uranium doses in broilers and protection with mineral adsorbents VL - 58 IS - 3 SP - 385 EP - 391 DO - 10.1007/s00411-019-00790-5 ER -
@article{ author = "Mitrović, Branislava and Stojanović, Mirjana and Sekulić, Zivko and Andrić, Velibor and Vićentijević, Mihajlo and Vranješ, Borjana", year = "2019", abstract = "The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed the highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%).", publisher = "Springer, New York", journal = "Radiation and Environmental Biophysics", title = "Toxicity of high uranium doses in broilers and protection with mineral adsorbents", volume = "58", number = "3", pages = "385-391", doi = "10.1007/s00411-019-00790-5" }
Mitrović, B., Stojanović, M., Sekulić, Z., Andrić, V., Vićentijević, M.,& Vranješ, B.. (2019). Toxicity of high uranium doses in broilers and protection with mineral adsorbents. in Radiation and Environmental Biophysics Springer, New York., 58(3), 385-391. https://doi.org/10.1007/s00411-019-00790-5
Mitrović B, Stojanović M, Sekulić Z, Andrić V, Vićentijević M, Vranješ B. Toxicity of high uranium doses in broilers and protection with mineral adsorbents. in Radiation and Environmental Biophysics. 2019;58(3):385-391. doi:10.1007/s00411-019-00790-5 .
Mitrović, Branislava, Stojanović, Mirjana, Sekulić, Zivko, Andrić, Velibor, Vićentijević, Mihajlo, Vranješ, Borjana, "Toxicity of high uranium doses in broilers and protection with mineral adsorbents" in Radiation and Environmental Biophysics, 58, no. 3 (2019):385-391, https://doi.org/10.1007/s00411-019-00790-5 . .