The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed th...e highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%).
TY - JOUR
AU - Mitrović, Branislava
AU - Stojanović, Mirjana
AU - Sekulić, Zivko
AU - Andrić, Velibor
AU - Vićentijević, Mihajlo
AU - Vranješ, Borjana
PY - 2019
UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1749
AB - The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed the highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%).
PB - Springer, New York
T2 - Radiation and Environmental Biophysics
T1 - Toxicity of high uranium doses in broilers and protection with mineral adsorbents
VL - 58
IS - 3
SP - 385
EP - 391
DO - 10.1007/s00411-019-00790-5
ER -
@article{
author = "Mitrović, Branislava and Stojanović, Mirjana and Sekulić, Zivko and Andrić, Velibor and Vićentijević, Mihajlo and Vranješ, Borjana",
year = "2019",
abstract = "The aim of this study was to determine the uranium distribution and histopathological changes in broiler organs (kidney, liver, and brain) and muscle after 7 days of contamination with high doses of uranyl nitrate hexahydrate (UN), and the protective efficiency of three different mineral adsorbents (organobentonite, organozeolite, and sepiolite). During the 7 days, the UN administration was 50mg per day, and administration of adsorbents was 2g per day immediately after UN. In control group where broilers received only UN, histopathological changes such as necrosis of intestinal villi, oedema, vacuolisation and abruption of epithelial cells in renal tubules, oedema and vacuolisation of the cytoplasm of hepatocytes, and dystrophic changes in the neurons of the medulla oblongata were observed. In contrast, when the adsorbents organobentonite, organozeolite, and sepiolite were administered, no histopathological changes were observed in liver and brain. The investigated adsorbents showed the highest protective effects in liver (80-92%), compared to the kidney (77-86%), brain (37-64%), and meat (31-63%).",
publisher = "Springer, New York",
journal = "Radiation and Environmental Biophysics",
title = "Toxicity of high uranium doses in broilers and protection with mineral adsorbents",
volume = "58",
number = "3",
pages = "385-391",
doi = "10.1007/s00411-019-00790-5"
}
Mitrović, B., Stojanović, M., Sekulić, Z., Andrić, V., Vićentijević, M.,& Vranješ, B.. (2019). Toxicity of high uranium doses in broilers and protection with mineral adsorbents. in Radiation and Environmental Biophysics
Springer, New York., 58(3), 385-391.
https://doi.org/10.1007/s00411-019-00790-5
Mitrović B, Stojanović M, Sekulić Z, Andrić V, Vićentijević M, Vranješ B. Toxicity of high uranium doses in broilers and protection with mineral adsorbents. in Radiation and Environmental Biophysics. 2019;58(3):385-391.
doi:10.1007/s00411-019-00790-5 .
Mitrović, Branislava, Stojanović, Mirjana, Sekulić, Zivko, Andrić, Velibor, Vićentijević, Mihajlo, Vranješ, Borjana, "Toxicity of high uranium doses in broilers and protection with mineral adsorbents" in Radiation and Environmental Biophysics, 58, no. 3 (2019):385-391,
https://doi.org/10.1007/s00411-019-00790-5 . .
