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dc.creatorStevanović, Ivana
dc.creatorMancić, Bojana
dc.creatorIlić, Tihomir
dc.creatorMilosavljević, Petar
dc.creatorLavrnja, Irena
dc.creatorStojanović, Ivana
dc.creatorNinković, Milica
dc.date.accessioned2020-06-03T14:34:17Z
dc.date.available2020-06-03T14:34:17Z
dc.date.issued2019
dc.identifier.issn1641-4640
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/1750
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in the activity of excitatory and inhibitory systems, restores these functions and suppresses the progression of disability in experimental autoimmune encephalitis (EAE). The structural type of TMS, the arrangement as theta burst stimulation (TBS) has been applied as intermittent TBS (iTBS) and continuous TBS (cTBS) protocols to female adult DA rats. The animals were randomly divided into experimental groups: control group (C), group treated with complete Freunds adjuvant (CFA), experimental autoimmune encephalomyelitis (EAE) group, group treated with iTBS post EAE immunization (EAE + iTBS), group treated with cTBS post EAE immunization (EAE + cTBS), group of healthy animals treated with iTBS or cTBS. Therapeutic protocols of iTBS or cTBS in all EAE groups of animals were performed starting from 14 days post immunization (dpi), for 10 days with time point decapitation at 24 dpi. After decapitation, spinal cords were analysed for BDNF and Ki67 expression. The results revealed reduced BDNF expression in the rats spinal cord of EAE animals in the stage of remission, which was associated with increased Ki67 and GFAP expressions. Decreased Iba 1 and BDNF expression, contrary to increased Iba 1 and Ki67 expression, suggests clustered microglia in the resolution phase of EAE. Enhanced GABA expression in spinal cord sections indicates higher GABA metabolic turnover, and also GAD activity in astrocytes, or prominent activity of GABAergic neurons. Both TBS protocols induced advance BDNF expression; amongst iTBS application provoked elevating of BDNF and stabilizing of GFAP and Ki67 expressions.en
dc.publisherTermedia Publishing House Ltd, Poznan
dc.relationUniversity of Defence [MFVMA/04/19-21]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceFolia Neuropathologica
dc.subjectexperimental autoimmune encephalomyelitis (EAE)en
dc.subjectspinal corden
dc.subjectTMSen
dc.subjectBDNFen
dc.titleTheta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitisen
dc.typearticle
dc.rights.licenseBY-NC-SA
dcterms.abstractМанцић, Бојана; Илић, Тихомир; Лаврња, Ирена; Нинковић, Милица; Стевановић, Ивана; Милосављевић, Петар; Стојановић, Ивана;
dc.citation.volume57
dc.citation.issue2
dc.citation.spage129
dc.citation.epage145
dc.citation.other57(2): 129-145
dc.citation.rankM23
dc.identifier.wos000475371600004
dc.identifier.doi10.5114/fn.2019.86294
dc.identifier.pmid31556573
dc.identifier.scopus2-s2.0-85072664097
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/711/1749.pdf
dc.type.versionpublishedVersion


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