Leaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNA
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Milosavljević, Slobodan M.
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Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
Keywords:Amphoricarpos neumayeri Vis / sesquiterpene lactones / in vitro protective effect on chromosome aberrations
Source:Natural Product Research, 2020
- Taylor & Francis Ltd, Abingdon
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Serbian Academy of Sciences and Arts [F-188]