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dc.creatorCvetković, Mirjana
dc.creatorĐorđević, Iris
dc.creatorJadranin, Milka
dc.creatorStanković, Miroslava
dc.creatorMandić, Boris
dc.creatorMilosavljević, Slobodan M.
dc.creatorVujisić, Ljubodrag
dc.date.accessioned2020-06-03T14:37:45Z
dc.date.available2020-06-03T14:37:45Z
dc.date.issued2020
dc.identifier.issn1478-6419
dc.identifier.urihttp://vet-erinar.vet.bg.ac.rs/handle/123456789/1799
dc.description.abstractAnalysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13-16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9 beta-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationSerbian Academy of Sciences and Arts [F-188]
dc.rightsrestrictedAccess
dc.sourceNatural Product Research
dc.subjectAmphoricarpos neumayeri Visen
dc.subjectsesquiterpene lactonesen
dc.subjectin vitro protective effect on chromosome aberrationsen
dc.titleLeaf-surface guaianolides from Amphoricarpos neumaeyri showing protective effect on human lymphocytes DNAen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилосављевић, Слободан М.; Ђорђевић, Ирис; Вујисић, Љубодраг; Мандић, Борис; Цветковић, Мирјана; Станковић, Мирослава; Јадранин, Милка;
dc.citation.rankM22~
dc.identifier.wos000495535100001
dc.identifier.doi10.1080/14786419.2019.1687470
dc.identifier.pmid31707853
dc.identifier.scopus2-s2.0-85075017367
dc.identifier.rcubconv_2524
dc.type.versionpublishedVersion


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