Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows
2020
Authors
Podpecan, OzbaltZrimsek, Petra
Mrkun, Janko
Golicnik, Marko
Radovanović, Anita
Jovanović, Ljubomir
Vujanac, Ivan
Prodanović, Radiša
Kirovski, Danijela
Article (Published version)
Metadata
Show full item recordAbstract
The objective was to determine optimal thresholds of blood variables that are associated with liver lipid and glycogen content in dairy cows. Liver specimens of 15 Holstein dairy cows were taken 2 weeks postpartum (PP) and used for determination of lipid and glycogen content, respectively. Blood samples were collected weekly, starting from week 2 antepartum (AP) up to week 2 PP. Selected blood parameters and body condition scoring (BCS) were evaluated through receiver operating characteristic curve analysis as indication of fat and glycogen content in the liver. Postpartal low liver glycogen content (mode < 2.0, semiquantitative analysis of glycogen content in the liver tissue samples) can be indicated if values are higher than 0.16 mmol/L, and 3.5 mmol/L for NEFA, and glucose, respectively, and lower than 0.65 mmol/L and 17.94 mu U/mL for BHBA and insulin, respectively, 2 weeks AP. Postaprtal high liver fat content (>20%, stereological quantification of fat content in the liver tissue... samples) can be indicated if values are higher than 3.5 for BCS at week 2 AP. Optimal time for indicating both low liver glycogen/high fat content is 1 week PP, with LDL < cut off point set at 0.18 mmol/L and BHBA > cut off point set at 0.88 mmol/L. Established cut off values in this study can be used for indication of fat and glycogen content in the liver of dairy cows.
Keywords:
Bovine liver / fat / glycogen / indicationSource:
Italian Journal of Animal Science, 2020, 19, 1, 303-309Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Molecular genetic and ecophysiological researches on the protection of autochthonous animal genetic resources, sustaining domestic animals’ welfare, health and reproduction, and safe food production (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
- Slovenian Research AgencySlovenian Research Agency - Slovenia [P4-0053]
DOI: 10.1080/1828051X.2020.1740064
ISSN: 1594-4077
WoS: 000519986000001
Scopus: 2-s2.0-85081902186
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Institution/Community
Fakultet veterinarske medicineTY - JOUR AU - Podpecan, Ozbalt AU - Zrimsek, Petra AU - Mrkun, Janko AU - Golicnik, Marko AU - Radovanović, Anita AU - Jovanović, Ljubomir AU - Vujanac, Ivan AU - Prodanović, Radiša AU - Kirovski, Danijela PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1823 AB - The objective was to determine optimal thresholds of blood variables that are associated with liver lipid and glycogen content in dairy cows. Liver specimens of 15 Holstein dairy cows were taken 2 weeks postpartum (PP) and used for determination of lipid and glycogen content, respectively. Blood samples were collected weekly, starting from week 2 antepartum (AP) up to week 2 PP. Selected blood parameters and body condition scoring (BCS) were evaluated through receiver operating characteristic curve analysis as indication of fat and glycogen content in the liver. Postpartal low liver glycogen content (mode < 2.0, semiquantitative analysis of glycogen content in the liver tissue samples) can be indicated if values are higher than 0.16 mmol/L, and 3.5 mmol/L for NEFA, and glucose, respectively, and lower than 0.65 mmol/L and 17.94 mu U/mL for BHBA and insulin, respectively, 2 weeks AP. Postaprtal high liver fat content (>20%, stereological quantification of fat content in the liver tissue samples) can be indicated if values are higher than 3.5 for BCS at week 2 AP. Optimal time for indicating both low liver glycogen/high fat content is 1 week PP, with LDL < cut off point set at 0.18 mmol/L and BHBA > cut off point set at 0.88 mmol/L. Established cut off values in this study can be used for indication of fat and glycogen content in the liver of dairy cows. PB - Taylor & Francis Ltd, Abingdon T2 - Italian Journal of Animal Science T1 - Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows VL - 19 IS - 1 SP - 303 EP - 309 DO - 10.1080/1828051X.2020.1740064 ER -
@article{ author = "Podpecan, Ozbalt and Zrimsek, Petra and Mrkun, Janko and Golicnik, Marko and Radovanović, Anita and Jovanović, Ljubomir and Vujanac, Ivan and Prodanović, Radiša and Kirovski, Danijela", year = "2020", abstract = "The objective was to determine optimal thresholds of blood variables that are associated with liver lipid and glycogen content in dairy cows. Liver specimens of 15 Holstein dairy cows were taken 2 weeks postpartum (PP) and used for determination of lipid and glycogen content, respectively. Blood samples were collected weekly, starting from week 2 antepartum (AP) up to week 2 PP. Selected blood parameters and body condition scoring (BCS) were evaluated through receiver operating characteristic curve analysis as indication of fat and glycogen content in the liver. Postpartal low liver glycogen content (mode < 2.0, semiquantitative analysis of glycogen content in the liver tissue samples) can be indicated if values are higher than 0.16 mmol/L, and 3.5 mmol/L for NEFA, and glucose, respectively, and lower than 0.65 mmol/L and 17.94 mu U/mL for BHBA and insulin, respectively, 2 weeks AP. Postaprtal high liver fat content (>20%, stereological quantification of fat content in the liver tissue samples) can be indicated if values are higher than 3.5 for BCS at week 2 AP. Optimal time for indicating both low liver glycogen/high fat content is 1 week PP, with LDL < cut off point set at 0.18 mmol/L and BHBA > cut off point set at 0.88 mmol/L. Established cut off values in this study can be used for indication of fat and glycogen content in the liver of dairy cows.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Italian Journal of Animal Science", title = "Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows", volume = "19", number = "1", pages = "303-309", doi = "10.1080/1828051X.2020.1740064" }
Podpecan, O., Zrimsek, P., Mrkun, J., Golicnik, M., Radovanović, A., Jovanović, L., Vujanac, I., Prodanović, R.,& Kirovski, D.. (2020). Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows. in Italian Journal of Animal Science Taylor & Francis Ltd, Abingdon., 19(1), 303-309. https://doi.org/10.1080/1828051X.2020.1740064
Podpecan O, Zrimsek P, Mrkun J, Golicnik M, Radovanović A, Jovanović L, Vujanac I, Prodanović R, Kirovski D. Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows. in Italian Journal of Animal Science. 2020;19(1):303-309. doi:10.1080/1828051X.2020.1740064 .
Podpecan, Ozbalt, Zrimsek, Petra, Mrkun, Janko, Golicnik, Marko, Radovanović, Anita, Jovanović, Ljubomir, Vujanac, Ivan, Prodanović, Radiša, Kirovski, Danijela, "Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows" in Italian Journal of Animal Science, 19, no. 1 (2020):303-309, https://doi.org/10.1080/1828051X.2020.1740064 . .