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Patohistološke promene i stepen sanacionih procesa u bubrezima brojlera tretiranih ohratoksinom A

dc.creatorNedeljković-Trailović, Jelena
dc.creatorSinovec, Snežana M.
dc.creatorSinovec, Zlatan
dc.date.accessioned2020-06-03T12:44:17Z
dc.date.available2020-06-03T12:44:17Z
dc.date.issued2001
dc.identifier.issn0567-8315
dc.identifier.urihttps://vet-erinar.vet.bg.ac.rs/handle/123456789/184
dc.description.abstractA 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 or 1.5 ppm ochratoxin A, respectively. After that period all groups were normally fed a mixture without added OTA until the end of the trial. Kidney samples were taken after the period of using contaminated feed, as well as after withdrawal the contaminated feed and a 3 week resting period. Proximal tubules were predominantly affected, while glomerules were chiefly preserved. The cytoplasm of tubulocytes was microgranulated and the nuclei were masked. Vacuolization was noticed in a certain number of altered cells. Foci of acute tubular necrosis were noticed in a few tubules. In some cases weak hemorrhage could be seen in affected areas. In the kidney samples of the group offered contaminated feed followed by a 3 week resting period morphological alterations were expressed in the form of intracellular edema. Epithelial cells of proximal tubules were enlarged with opaque cytoplasm, which caused tubule lumen stenosis. Apoptotic bodies could be noticed between some tubulocytes. The obtained results suggest that kidney alterations induced by OTA could be restored only to a certain extent as well as that minimum three week resting period is necessary for this process.en
dc.description.abstractOgled je izveden na 48 Hybro brojlera podeljenih u četiri grupe i trajao je 42 dana. Od 14 dana ogledne grupe su tokom 7 dana dobijale hranu koja je sadržala 0.5,1.0 ili 1.5 ppm OA. Uzorci bubrega za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci bubrega ponovo uzeti. Patohistološkim ispitivanjem utvrđeno je da su pretežno proksimalni tubuli zahvaćeni promenama, dok su glomeruli uglavnom očuvani. Citoplazma tubulocita je sitnozrnasta, a jedra su maskirana. U pojedinim ćelijama uočena je vakuolizacija, dok su u manjem broju tubula uočeni fokusi akutne nekroze. U promenjenim zonama uočena su slaba krvavljenja. U uzorcima bubrega grupa hranjenih kontaminiranom, a zatim nekontaminiranom hranom promene su se ispoljile u vidu intracelularnog edema. Epitelne ćelije proksimalnih tubula su povećane sa zamućenom citoplazmom što je u pojedinim slučajevima izazvalo su'avanje lumena tubula. Apoptotična tela su uočena između pojedinih tubulocita. Dobijeni rezultati ukazuju da se promene u bubrezima izazvane OA mogu samo delom i u određenom stepenu restituisati, a da za je ove procese potreban period od najmanje tri nedelje.sr
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsopenAccess
dc.sourceActa Veterinaria-Beograd
dc.subjectpoultryen
dc.subjectochratoxin Aen
dc.subjectpathomorphological alterationsen
dc.subjectreparatory processesen
dc.titlePathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochtratoxin Aen
dc.titlePatohistološke promene i stepen sanacionih procesa u bubrezima brojlera tretiranih ohratoksinom Asr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСиновец, Златан; Синовец, Снежана М.; Недељковић-Траиловић, Јелена; Патохистолошке промене и степен санационих процеса у бубрезима бројлера третираних охратоксином A; Патохистолошке промене и степен санационих процеса у бубрезима бројлера третираних охратоксином A;
dc.citation.volume51
dc.citation.issue5-6
dc.citation.spage333
dc.citation.epage341
dc.citation.other51(5-6): 333-341
dc.citation.rankM23
dc.identifier.wos000173454000008
dc.identifier.scopus2-s2.0-0346409198
dc.identifier.fulltexthttps://vet-erinar.vet.bg.ac.rs/bitstream/id/792/183.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_veterinar_184
dc.type.versionpublishedVersion


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