Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity
2020
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Mišić, DušanTadić, Vanja
Korzeniowska, Malgorzata
Nišavić, Jakov
Aksentijević, Ksenija
Kuzmanovic, Jelena
Žižović, Irena
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Supercritical fluid extraction as an environmentally friendly technology was applied to isolate biologically active extracts from celery and parsley fruits for potential applications in the food industry. The extractions were performed under mild temperature conditions of 39.85 °C and at pressures of 10 and 30 MPa. The extracts were analyzed regarding their chemical composition, antibacterial activity, and cytotoxic effect. Sedanolide was the dominant component of the celery fruit extracts, comprising more than 70% of the obtained fraction, while the content of apiole in the parsley fruit SC CO2 extracts exceeded 85%. The celery fruit extracts showed strong and moderately strong antibacterial activity against tested Staphylococcus aureus, Bacillus (B.) cereus, B. subtilis, B. circulans, Listeria (L.) greyi, L. seeligeri and L. welshimeri, with minimal inhibitory concentration (MIC) values between 160 and 640 µg/mL, and weak activity against the selected Salmonella isolates with a MIC o...f 2560 µg/mL. The parsley extract obtained at 10 MPa showed strong and moderately strong antibacterial effects against Bacillus strains with obtained MICs of 160-640 µg/mL, and weak activity against Staphylococcus, Listeria, and Salmonella with a MIC of 2560 µg/mL. Cytotoxicity investigation showed that the extracts with proven antibacterial activity had no cytotoxic effect on rabbit kidney cells at concentrations of up to 640 µg/mL.
Keywords:
antibacterial activity / celery / cytotoxicity / parsley / supercritical extractionSource:
Molecules (Basel, Switzerland), 2020, 25, 14Publisher:
- MDPI
DOI: 10.3390/molecules25143163
ISSN: 1420-3049
WoS: 000557350400001
Scopus: 2-s2.0-85088014788
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Fakultet veterinarske medicineTY - JOUR AU - Mišić, Dušan AU - Tadić, Vanja AU - Korzeniowska, Malgorzata AU - Nišavić, Jakov AU - Aksentijević, Ksenija AU - Kuzmanovic, Jelena AU - Žižović, Irena PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1855 AB - Supercritical fluid extraction as an environmentally friendly technology was applied to isolate biologically active extracts from celery and parsley fruits for potential applications in the food industry. The extractions were performed under mild temperature conditions of 39.85 °C and at pressures of 10 and 30 MPa. The extracts were analyzed regarding their chemical composition, antibacterial activity, and cytotoxic effect. Sedanolide was the dominant component of the celery fruit extracts, comprising more than 70% of the obtained fraction, while the content of apiole in the parsley fruit SC CO2 extracts exceeded 85%. The celery fruit extracts showed strong and moderately strong antibacterial activity against tested Staphylococcus aureus, Bacillus (B.) cereus, B. subtilis, B. circulans, Listeria (L.) greyi, L. seeligeri and L. welshimeri, with minimal inhibitory concentration (MIC) values between 160 and 640 µg/mL, and weak activity against the selected Salmonella isolates with a MIC of 2560 µg/mL. The parsley extract obtained at 10 MPa showed strong and moderately strong antibacterial effects against Bacillus strains with obtained MICs of 160-640 µg/mL, and weak activity against Staphylococcus, Listeria, and Salmonella with a MIC of 2560 µg/mL. Cytotoxicity investigation showed that the extracts with proven antibacterial activity had no cytotoxic effect on rabbit kidney cells at concentrations of up to 640 µg/mL. PB - MDPI T2 - Molecules (Basel, Switzerland) T1 - Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity VL - 25 IS - 14 DO - 10.3390/molecules25143163 ER -
@article{ author = "Mišić, Dušan and Tadić, Vanja and Korzeniowska, Malgorzata and Nišavić, Jakov and Aksentijević, Ksenija and Kuzmanovic, Jelena and Žižović, Irena", year = "2020", abstract = "Supercritical fluid extraction as an environmentally friendly technology was applied to isolate biologically active extracts from celery and parsley fruits for potential applications in the food industry. The extractions were performed under mild temperature conditions of 39.85 °C and at pressures of 10 and 30 MPa. The extracts were analyzed regarding their chemical composition, antibacterial activity, and cytotoxic effect. Sedanolide was the dominant component of the celery fruit extracts, comprising more than 70% of the obtained fraction, while the content of apiole in the parsley fruit SC CO2 extracts exceeded 85%. The celery fruit extracts showed strong and moderately strong antibacterial activity against tested Staphylococcus aureus, Bacillus (B.) cereus, B. subtilis, B. circulans, Listeria (L.) greyi, L. seeligeri and L. welshimeri, with minimal inhibitory concentration (MIC) values between 160 and 640 µg/mL, and weak activity against the selected Salmonella isolates with a MIC of 2560 µg/mL. The parsley extract obtained at 10 MPa showed strong and moderately strong antibacterial effects against Bacillus strains with obtained MICs of 160-640 µg/mL, and weak activity against Staphylococcus, Listeria, and Salmonella with a MIC of 2560 µg/mL. Cytotoxicity investigation showed that the extracts with proven antibacterial activity had no cytotoxic effect on rabbit kidney cells at concentrations of up to 640 µg/mL.", publisher = "MDPI", journal = "Molecules (Basel, Switzerland)", title = "Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity", volume = "25", number = "14", doi = "10.3390/molecules25143163" }
Mišić, D., Tadić, V., Korzeniowska, M., Nišavić, J., Aksentijević, K., Kuzmanovic, J.,& Žižović, I.. (2020). Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity. in Molecules (Basel, Switzerland) MDPI., 25(14). https://doi.org/10.3390/molecules25143163
Mišić D, Tadić V, Korzeniowska M, Nišavić J, Aksentijević K, Kuzmanovic J, Žižović I. Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity. in Molecules (Basel, Switzerland). 2020;25(14). doi:10.3390/molecules25143163 .
Mišić, Dušan, Tadić, Vanja, Korzeniowska, Malgorzata, Nišavić, Jakov, Aksentijević, Ksenija, Kuzmanovic, Jelena, Žižović, Irena, "Supercritical Fluid Extraction of Celery and Parsley Fruit-Chemical Composition and Antibacterial Activity" in Molecules (Basel, Switzerland), 25, no. 14 (2020), https://doi.org/10.3390/molecules25143163 . .