Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums
Koncentracija IGF-I i ukupnih proteina u krvnom serumu novorođene teladi napajane različitom količinom kolostruma
Апстракт
The aim of this investigation was to determine the concentrations of insulin like growth factor-I (IGF-I) and total protein in blood serum from calves consuming different amounts of colostrum during the first 32 h of postnatal life, as well as at 7 days old. The experiment involved two groups of calves. The first group was offered the standard amount of colostrum while the second group received half the recommended amount. At birth serum concentration of IGF-I was in the range from 5 to 13 nmol/L. Compared to the initial level there was a marked decrease of mean IGF-I concentration in both groups of calves at 2 h after the first intake of colostrum. Thereafter, the level gradually increased until 20 h of age, more markedly in the group which received the full ration of colostrum. The highest mean IGF-I concentrations were recorded at 20 h in both groups (11.81 nmol/L for group one and 8.96 nmol/L for group two), and were significantly higher than values recorded 2h after the first inta...ke of colostrum. Two hours after the third intake of colostrum, serum concentration of IGF-I dropped in both groups, compared with the value recorded at 20 h. During the time period from 4hto32h after birth, the calves that received the standard amount of colostrum had a significantly higher mean concentration of serum IGF-I than the calves which received an insufficient amount. Calves were born with serum concentrations of total proteins, which were lower than those found for adult animals. Serum protein concentrations in the calves that consumed normal amounts of colostrum increased more rapidly than in the calves that received insufficient amounts of colostrum. Presumably, total protein concentrations increased as a consequence of colostral immunoglobulin absorption. Thus our results indicate that the amounts of colostrum received during the first 32 h of postnatal life had strong effects on the serum concentrations of IGF-I and total proteins. The differences in IGF-I concentrations between the two groups of calves may have been a consequence of greater colostral IGF-I absorption and/or the result of greater absorption of other colostral components, which stimulate endogenous synthesis of this bioactive substance in the tissues of neonatal calves.
Cilj ovog rada bio je da se odrede koncentracije insulinu sličnog faktora rasta-l (IGF-I) i ukupnih proteina u krvnom serumu teladi koja su napajana različitom količinom kolostruma tokom prvih 32 sata postnatalnog života kao i 7. dana života. Ogled je izveden na dve grupe od po osam teladi: prva grupa teladi je napajana sa normalnom količinom kolostruma, dok je druga grupa bila napajana sa duplo manjom količinom kolostruma. Koncentracija IGF-I u krvnom serumu teladi pri rođenju bila je u rasponu od 5 do 13 nmol/L. Nakon napajanja prvim kolostrumom kod obe grupe je došlo do značajnog pada koncentracije IGF-I u odnosu na koncentraciju određenu nultog sata života. Posle toga koncentracija je kod obe grupe postepeno rasla do 20. sata života pri čemu je porast bio izraženiji kod grupe koja je napajana normalnom količinom kolostruma. 20. sata je kod obe grupe utvrđena najviša koncentracija IGF-I (11.81 nmol/L u krvnom serumu prve grupe i 8.96 nmol/L u krvnom serumu druge grupe teladi) i ona ...je bila značajno visa od vrednosti utvrđene 4. sata života, a dva sata posle prvog kolostralnog napoja. Dva sata nakon napajanja trećim kolostrumom došlo je do pada koncentracije IGF-I u krvnom serumu obe grupe teladi, pri čemu je pad bio statistički značajan u odnosu na 20. sat života samo kod druge grupe. U vremenskom periodu od 4. do 32. sata života telad prve grupe koja su napajana normalnom količinom kolostruma imala su statistički značajno višu koncentraciju IGF-I u krvnom serumu u odnosu na telad koja su napajana manjom količinom kolostruma. Telad obe ogledne grupe su rođena sa koncentracijom proteina koja je značajno niža nego kod odraslih jedinki. Porast koncentracije proteina u krvnom serumu teladi napajane sa duplo manjom količinom kolostruma u ispitivanom periodu je bio znatno sporiji u poređenju sa rastom proteinemije teladi prve ogledne grupe. Naši rezultati ukazuju da nivo popijenog kolostruma u prva 32h neonatalnog života ima veliki uticaj na koncentraciju insulinu sličnog faktora rasta I (IGF-I) i ukupnih proteina. Za porast proteinemije možemo sa sigurnošću tvrditi da je rezultat resorpcije kolostralnih imunoglobulina. Različiti nivoi IGF-I utvrđeni u našem ogledu na dve grupe teladi mogu biti posledica veće resorpcije IGF-I prisutnog u kolostrumu i/ili veće resorpcije nekih od još neidentifikovanih sastojaka kolostruma koji indukuju endogenu sintezu ovog biološki aktivnog jedinjenja u mnogim tkivima novorođene jedinke.
Кључне речи:
neonatal calves / colostrum / insulin like growth factor-! / total protein / immunoglobulinsИзвор:
Acta Veterinaria-Beograd, 2002, 52, 5-6, 285-297Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2298/AVB0206285K
ISSN: 0567-8315
WoS: 000180300700001
Scopus: 2-s2.0-0036975949
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Kirovski, Danijela AU - Stojić, Velibor AU - Nikolić-Judith, Anna PY - 2002 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/194 AB - The aim of this investigation was to determine the concentrations of insulin like growth factor-I (IGF-I) and total protein in blood serum from calves consuming different amounts of colostrum during the first 32 h of postnatal life, as well as at 7 days old. The experiment involved two groups of calves. The first group was offered the standard amount of colostrum while the second group received half the recommended amount. At birth serum concentration of IGF-I was in the range from 5 to 13 nmol/L. Compared to the initial level there was a marked decrease of mean IGF-I concentration in both groups of calves at 2 h after the first intake of colostrum. Thereafter, the level gradually increased until 20 h of age, more markedly in the group which received the full ration of colostrum. The highest mean IGF-I concentrations were recorded at 20 h in both groups (11.81 nmol/L for group one and 8.96 nmol/L for group two), and were significantly higher than values recorded 2h after the first intake of colostrum. Two hours after the third intake of colostrum, serum concentration of IGF-I dropped in both groups, compared with the value recorded at 20 h. During the time period from 4hto32h after birth, the calves that received the standard amount of colostrum had a significantly higher mean concentration of serum IGF-I than the calves which received an insufficient amount. Calves were born with serum concentrations of total proteins, which were lower than those found for adult animals. Serum protein concentrations in the calves that consumed normal amounts of colostrum increased more rapidly than in the calves that received insufficient amounts of colostrum. Presumably, total protein concentrations increased as a consequence of colostral immunoglobulin absorption. Thus our results indicate that the amounts of colostrum received during the first 32 h of postnatal life had strong effects on the serum concentrations of IGF-I and total proteins. The differences in IGF-I concentrations between the two groups of calves may have been a consequence of greater colostral IGF-I absorption and/or the result of greater absorption of other colostral components, which stimulate endogenous synthesis of this bioactive substance in the tissues of neonatal calves. AB - Cilj ovog rada bio je da se odrede koncentracije insulinu sličnog faktora rasta-l (IGF-I) i ukupnih proteina u krvnom serumu teladi koja su napajana različitom količinom kolostruma tokom prvih 32 sata postnatalnog života kao i 7. dana života. Ogled je izveden na dve grupe od po osam teladi: prva grupa teladi je napajana sa normalnom količinom kolostruma, dok je druga grupa bila napajana sa duplo manjom količinom kolostruma. Koncentracija IGF-I u krvnom serumu teladi pri rođenju bila je u rasponu od 5 do 13 nmol/L. Nakon napajanja prvim kolostrumom kod obe grupe je došlo do značajnog pada koncentracije IGF-I u odnosu na koncentraciju određenu nultog sata života. Posle toga koncentracija je kod obe grupe postepeno rasla do 20. sata života pri čemu je porast bio izraženiji kod grupe koja je napajana normalnom količinom kolostruma. 20. sata je kod obe grupe utvrđena najviša koncentracija IGF-I (11.81 nmol/L u krvnom serumu prve grupe i 8.96 nmol/L u krvnom serumu druge grupe teladi) i ona je bila značajno visa od vrednosti utvrđene 4. sata života, a dva sata posle prvog kolostralnog napoja. Dva sata nakon napajanja trećim kolostrumom došlo je do pada koncentracije IGF-I u krvnom serumu obe grupe teladi, pri čemu je pad bio statistički značajan u odnosu na 20. sat života samo kod druge grupe. U vremenskom periodu od 4. do 32. sata života telad prve grupe koja su napajana normalnom količinom kolostruma imala su statistički značajno višu koncentraciju IGF-I u krvnom serumu u odnosu na telad koja su napajana manjom količinom kolostruma. Telad obe ogledne grupe su rođena sa koncentracijom proteina koja je značajno niža nego kod odraslih jedinki. Porast koncentracije proteina u krvnom serumu teladi napajane sa duplo manjom količinom kolostruma u ispitivanom periodu je bio znatno sporiji u poređenju sa rastom proteinemije teladi prve ogledne grupe. Naši rezultati ukazuju da nivo popijenog kolostruma u prva 32h neonatalnog života ima veliki uticaj na koncentraciju insulinu sličnog faktora rasta I (IGF-I) i ukupnih proteina. Za porast proteinemije možemo sa sigurnošću tvrditi da je rezultat resorpcije kolostralnih imunoglobulina. Različiti nivoi IGF-I utvrđeni u našem ogledu na dve grupe teladi mogu biti posledica veće resorpcije IGF-I prisutnog u kolostrumu i/ili veće resorpcije nekih od još neidentifikovanih sastojaka kolostruma koji indukuju endogenu sintezu ovog biološki aktivnog jedinjenja u mnogim tkivima novorođene jedinke. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums T1 - Koncentracija IGF-I i ukupnih proteina u krvnom serumu novorođene teladi napajane različitom količinom kolostruma VL - 52 IS - 5-6 SP - 285 EP - 297 DO - 10.2298/AVB0206285K ER -
@article{ author = "Kirovski, Danijela and Stojić, Velibor and Nikolić-Judith, Anna", year = "2002", abstract = "The aim of this investigation was to determine the concentrations of insulin like growth factor-I (IGF-I) and total protein in blood serum from calves consuming different amounts of colostrum during the first 32 h of postnatal life, as well as at 7 days old. The experiment involved two groups of calves. The first group was offered the standard amount of colostrum while the second group received half the recommended amount. At birth serum concentration of IGF-I was in the range from 5 to 13 nmol/L. Compared to the initial level there was a marked decrease of mean IGF-I concentration in both groups of calves at 2 h after the first intake of colostrum. Thereafter, the level gradually increased until 20 h of age, more markedly in the group which received the full ration of colostrum. The highest mean IGF-I concentrations were recorded at 20 h in both groups (11.81 nmol/L for group one and 8.96 nmol/L for group two), and were significantly higher than values recorded 2h after the first intake of colostrum. Two hours after the third intake of colostrum, serum concentration of IGF-I dropped in both groups, compared with the value recorded at 20 h. During the time period from 4hto32h after birth, the calves that received the standard amount of colostrum had a significantly higher mean concentration of serum IGF-I than the calves which received an insufficient amount. Calves were born with serum concentrations of total proteins, which were lower than those found for adult animals. Serum protein concentrations in the calves that consumed normal amounts of colostrum increased more rapidly than in the calves that received insufficient amounts of colostrum. Presumably, total protein concentrations increased as a consequence of colostral immunoglobulin absorption. Thus our results indicate that the amounts of colostrum received during the first 32 h of postnatal life had strong effects on the serum concentrations of IGF-I and total proteins. The differences in IGF-I concentrations between the two groups of calves may have been a consequence of greater colostral IGF-I absorption and/or the result of greater absorption of other colostral components, which stimulate endogenous synthesis of this bioactive substance in the tissues of neonatal calves., Cilj ovog rada bio je da se odrede koncentracije insulinu sličnog faktora rasta-l (IGF-I) i ukupnih proteina u krvnom serumu teladi koja su napajana različitom količinom kolostruma tokom prvih 32 sata postnatalnog života kao i 7. dana života. Ogled je izveden na dve grupe od po osam teladi: prva grupa teladi je napajana sa normalnom količinom kolostruma, dok je druga grupa bila napajana sa duplo manjom količinom kolostruma. Koncentracija IGF-I u krvnom serumu teladi pri rođenju bila je u rasponu od 5 do 13 nmol/L. Nakon napajanja prvim kolostrumom kod obe grupe je došlo do značajnog pada koncentracije IGF-I u odnosu na koncentraciju određenu nultog sata života. Posle toga koncentracija je kod obe grupe postepeno rasla do 20. sata života pri čemu je porast bio izraženiji kod grupe koja je napajana normalnom količinom kolostruma. 20. sata je kod obe grupe utvrđena najviša koncentracija IGF-I (11.81 nmol/L u krvnom serumu prve grupe i 8.96 nmol/L u krvnom serumu druge grupe teladi) i ona je bila značajno visa od vrednosti utvrđene 4. sata života, a dva sata posle prvog kolostralnog napoja. Dva sata nakon napajanja trećim kolostrumom došlo je do pada koncentracije IGF-I u krvnom serumu obe grupe teladi, pri čemu je pad bio statistički značajan u odnosu na 20. sat života samo kod druge grupe. U vremenskom periodu od 4. do 32. sata života telad prve grupe koja su napajana normalnom količinom kolostruma imala su statistički značajno višu koncentraciju IGF-I u krvnom serumu u odnosu na telad koja su napajana manjom količinom kolostruma. Telad obe ogledne grupe su rođena sa koncentracijom proteina koja je značajno niža nego kod odraslih jedinki. Porast koncentracije proteina u krvnom serumu teladi napajane sa duplo manjom količinom kolostruma u ispitivanom periodu je bio znatno sporiji u poređenju sa rastom proteinemije teladi prve ogledne grupe. Naši rezultati ukazuju da nivo popijenog kolostruma u prva 32h neonatalnog života ima veliki uticaj na koncentraciju insulinu sličnog faktora rasta I (IGF-I) i ukupnih proteina. Za porast proteinemije možemo sa sigurnošću tvrditi da je rezultat resorpcije kolostralnih imunoglobulina. Različiti nivoi IGF-I utvrđeni u našem ogledu na dve grupe teladi mogu biti posledica veće resorpcije IGF-I prisutnog u kolostrumu i/ili veće resorpcije nekih od još neidentifikovanih sastojaka kolostruma koji indukuju endogenu sintezu ovog biološki aktivnog jedinjenja u mnogim tkivima novorođene jedinke.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums, Koncentracija IGF-I i ukupnih proteina u krvnom serumu novorođene teladi napajane različitom količinom kolostruma", volume = "52", number = "5-6", pages = "285-297", doi = "10.2298/AVB0206285K" }
Kirovski, D., Stojić, V.,& Nikolić-Judith, A.. (2002). Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 52(5-6), 285-297. https://doi.org/10.2298/AVB0206285K
Kirovski D, Stojić V, Nikolić-Judith A. Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums. in Acta Veterinaria-Beograd. 2002;52(5-6):285-297. doi:10.2298/AVB0206285K .
Kirovski, Danijela, Stojić, Velibor, Nikolić-Judith, Anna, "Serum levels of insulin like growth factor-l and total protein in newborn calves offered different amounts of colostrums" in Acta Veterinaria-Beograd, 52, no. 5-6 (2002):285-297, https://doi.org/10.2298/AVB0206285K . .