Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats
Само за регистроване кориснике
2020
Аутори
Sretenovic, JasminaZivkovic, Vladimir
Srejovic, Ivan
Ajdzanovic, Vladimir
Ristic, Nataša
Trifunovic, Miroljub
Pantovic, Suzana
Jovic, Slavoljub
Jakovljevic, Vladimir
Bolevich, Sergey
Milosavljevic, Zoran
Milosevic, Verica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of the study was to investigate the effects of chronic nandrolone decanoate treatment and/or swimming training on immunohistomorphometric parameters on rat pituitary gonadotropic cells. Male Wistar albino rats, 10 weeks old, were classified into four groups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training with nandrolone (T+N+). The T+ groups swam for 4 weeks, 1 h/day, 5 days/week. The N+ groups received nandrolone decanoate (20 mg/kg) once per week for 4 weeks. Pituitary tissue sections were processed and stained for immunohistochemical analysis and immunofluorescence. The volume density of luteinizing hormone (LH) cells was decreased by 48% in T-N+ and for 35% in the T+N+ group. The volume density of follicle-stimulating hormone (FSH) cells was decreased by 39% in T-N+ and for 30% in T+N+ compared to the control. Nandrolone alone, or combined with swimming training, decreased the number of LH/FSH cells compared to the control. The levels of ...the immunofluorescent signal of LH/FSH cells were increased in all experimental groups. Nandrolone alone decreased the serum level of LH by 17%, whereas swimming training alone increased FSH levels by 11% compared to the control. Serum levels of testosterone were increased in all experimental groups. Nandrolone alone, or combined with swimming training, decreased immunohistomorphometric parameters of gonadotropic cells, whereas the levels of immunofluorescent signal were increased.
Кључне речи:
FSH / LH / nandrolone / pituitary / swimming / testosteroneИзвор:
Microscopy and Microanalysis, 2020, 26, 4, 699-707Издавач:
- Cambridge University Press
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.1017/S143192762000166X
ISSN: 1431-9276
WoS: 000555537900008
Scopus: 2-s2.0-85086700146
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Sretenovic, Jasmina AU - Zivkovic, Vladimir AU - Srejovic, Ivan AU - Ajdzanovic, Vladimir AU - Ristic, Nataša AU - Trifunovic, Miroljub AU - Pantovic, Suzana AU - Jovic, Slavoljub AU - Jakovljevic, Vladimir AU - Bolevich, Sergey AU - Milosavljevic, Zoran AU - Milosevic, Verica PY - 2020 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/1968 AB - The aim of the study was to investigate the effects of chronic nandrolone decanoate treatment and/or swimming training on immunohistomorphometric parameters on rat pituitary gonadotropic cells. Male Wistar albino rats, 10 weeks old, were classified into four groups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training with nandrolone (T+N+). The T+ groups swam for 4 weeks, 1 h/day, 5 days/week. The N+ groups received nandrolone decanoate (20 mg/kg) once per week for 4 weeks. Pituitary tissue sections were processed and stained for immunohistochemical analysis and immunofluorescence. The volume density of luteinizing hormone (LH) cells was decreased by 48% in T-N+ and for 35% in the T+N+ group. The volume density of follicle-stimulating hormone (FSH) cells was decreased by 39% in T-N+ and for 30% in T+N+ compared to the control. Nandrolone alone, or combined with swimming training, decreased the number of LH/FSH cells compared to the control. The levels of the immunofluorescent signal of LH/FSH cells were increased in all experimental groups. Nandrolone alone decreased the serum level of LH by 17%, whereas swimming training alone increased FSH levels by 11% compared to the control. Serum levels of testosterone were increased in all experimental groups. Nandrolone alone, or combined with swimming training, decreased immunohistomorphometric parameters of gonadotropic cells, whereas the levels of immunofluorescent signal were increased. PB - Cambridge University Press T2 - Microscopy and Microanalysis T1 - Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats VL - 26 IS - 4 SP - 699 EP - 707 DO - 10.1017/S143192762000166X ER -
@article{ author = "Sretenovic, Jasmina and Zivkovic, Vladimir and Srejovic, Ivan and Ajdzanovic, Vladimir and Ristic, Nataša and Trifunovic, Miroljub and Pantovic, Suzana and Jovic, Slavoljub and Jakovljevic, Vladimir and Bolevich, Sergey and Milosavljevic, Zoran and Milosevic, Verica", year = "2020", abstract = "The aim of the study was to investigate the effects of chronic nandrolone decanoate treatment and/or swimming training on immunohistomorphometric parameters on rat pituitary gonadotropic cells. Male Wistar albino rats, 10 weeks old, were classified into four groups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training with nandrolone (T+N+). The T+ groups swam for 4 weeks, 1 h/day, 5 days/week. The N+ groups received nandrolone decanoate (20 mg/kg) once per week for 4 weeks. Pituitary tissue sections were processed and stained for immunohistochemical analysis and immunofluorescence. The volume density of luteinizing hormone (LH) cells was decreased by 48% in T-N+ and for 35% in the T+N+ group. The volume density of follicle-stimulating hormone (FSH) cells was decreased by 39% in T-N+ and for 30% in T+N+ compared to the control. Nandrolone alone, or combined with swimming training, decreased the number of LH/FSH cells compared to the control. The levels of the immunofluorescent signal of LH/FSH cells were increased in all experimental groups. Nandrolone alone decreased the serum level of LH by 17%, whereas swimming training alone increased FSH levels by 11% compared to the control. Serum levels of testosterone were increased in all experimental groups. Nandrolone alone, or combined with swimming training, decreased immunohistomorphometric parameters of gonadotropic cells, whereas the levels of immunofluorescent signal were increased.", publisher = "Cambridge University Press", journal = "Microscopy and Microanalysis", title = "Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats", volume = "26", number = "4", pages = "699-707", doi = "10.1017/S143192762000166X" }
Sretenovic, J., Zivkovic, V., Srejovic, I., Ajdzanovic, V., Ristic, N., Trifunovic, M., Pantovic, S., Jovic, S., Jakovljevic, V., Bolevich, S., Milosavljevic, Z.,& Milosevic, V.. (2020). Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats. in Microscopy and Microanalysis Cambridge University Press., 26(4), 699-707. https://doi.org/10.1017/S143192762000166X
Sretenovic J, Zivkovic V, Srejovic I, Ajdzanovic V, Ristic N, Trifunovic M, Pantovic S, Jovic S, Jakovljevic V, Bolevich S, Milosavljevic Z, Milosevic V. Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats. in Microscopy and Microanalysis. 2020;26(4):699-707. doi:10.1017/S143192762000166X .
Sretenovic, Jasmina, Zivkovic, Vladimir, Srejovic, Ivan, Ajdzanovic, Vladimir, Ristic, Nataša, Trifunovic, Miroljub, Pantovic, Suzana, Jovic, Slavoljub, Jakovljevic, Vladimir, Bolevich, Sergey, Milosavljevic, Zoran, Milosevic, Verica, "Immunohistomorphometric and Hormonal Analysis of the Pituitary Gonadotropic Cells after Application of the Nandrolone Decanoate and Swimming Training in Adult Male Rats" in Microscopy and Microanalysis, 26, no. 4 (2020):699-707, https://doi.org/10.1017/S143192762000166X . .