Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis
Само за регистроване кориснике
2021
Чланак у часопису (Објављена верзија)
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Herbs and spices have been used throughout human history for their medicinal qualities. The advent of cheap and readily available medicines have lessened the need for herbs and spices as traditional medicines, however, they are rapidly regaining popularity with rising interest of the general population in health, natural products and nutrition. The need for alternative medicines with antimicrobial properties, such as herbs and spices, has also come to the forefront in light of the recent bans of antibiotic use in the livestock industry, including the poultry industry. This large scale use presents an opportunity to observe nutrigenomic effects of prolonged use of herbs on a substantial number of birds fed high concentrations of these products throughout the production cycle. In this manuscript, we investigated the transcriptional effect of continual prolonged oregano supplementation on chicken ileum gene expression. Based on ileum transcriptomics, we report that continual supplementati...on with 2% oregano altered microbiota-gut-brain axis signalling, rearranged cancer susceptibility towards reduced steroid hormone-related cancers and altered expression of genes targeted by many registered drugs, thus likely affecting their efficiency and side effects. Transcriptional toxicology analysis indicated significant activation of Ventricular Septal Defect and Congenital Heart Disease categories. Our results, counter the notion that natural products such as oregano have the potential for little to no side-effects as they are “natural”. The nutrigenomic approach of understanding benefits and side effects of the food we eat, can revolutionize disease management and therapy and have special significance in designing the diets for individuals or livestock with known disease predispositions.
Извор:
Food and Function, 2021, 12, 2, 726-738Издавач:
- Royal Society of Chemistry
Финансирање / пројекти:
- This research did not receive any specific grant from funding agencies or the commercial sector. The project was funded internally by the Central Queensland University Merit Grant scheme. The data was analyzed using the Marie Curie High- Performance Computing System at Central Queensland University. We wish to acknowledge and appreciate help from Jason Bell provided in all aspects of High-Performance Computing. We also thank Benjamin Bauer and Nicky-Lee Willson for running the animal trial.
DOI: 10.1039/d0fo02988b
ISSN: 2042-6496
WoS: 000613889000016
Scopus: 2-s2.0-85100241843
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Bajagai, Yadav S. AU - Steel, Jason C. AU - Radovanovic, Anita AU - Stanley, Dragana PY - 2021 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2014 AB - Herbs and spices have been used throughout human history for their medicinal qualities. The advent of cheap and readily available medicines have lessened the need for herbs and spices as traditional medicines, however, they are rapidly regaining popularity with rising interest of the general population in health, natural products and nutrition. The need for alternative medicines with antimicrobial properties, such as herbs and spices, has also come to the forefront in light of the recent bans of antibiotic use in the livestock industry, including the poultry industry. This large scale use presents an opportunity to observe nutrigenomic effects of prolonged use of herbs on a substantial number of birds fed high concentrations of these products throughout the production cycle. In this manuscript, we investigated the transcriptional effect of continual prolonged oregano supplementation on chicken ileum gene expression. Based on ileum transcriptomics, we report that continual supplementation with 2% oregano altered microbiota-gut-brain axis signalling, rearranged cancer susceptibility towards reduced steroid hormone-related cancers and altered expression of genes targeted by many registered drugs, thus likely affecting their efficiency and side effects. Transcriptional toxicology analysis indicated significant activation of Ventricular Septal Defect and Congenital Heart Disease categories. Our results, counter the notion that natural products such as oregano have the potential for little to no side-effects as they are “natural”. The nutrigenomic approach of understanding benefits and side effects of the food we eat, can revolutionize disease management and therapy and have special significance in designing the diets for individuals or livestock with known disease predispositions. PB - Royal Society of Chemistry T2 - Food and Function T1 - Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis VL - 12 IS - 2 SP - 726 EP - 738 DO - 10.1039/d0fo02988b ER -
@article{ author = "Bajagai, Yadav S. and Steel, Jason C. and Radovanovic, Anita and Stanley, Dragana", year = "2021", abstract = "Herbs and spices have been used throughout human history for their medicinal qualities. The advent of cheap and readily available medicines have lessened the need for herbs and spices as traditional medicines, however, they are rapidly regaining popularity with rising interest of the general population in health, natural products and nutrition. The need for alternative medicines with antimicrobial properties, such as herbs and spices, has also come to the forefront in light of the recent bans of antibiotic use in the livestock industry, including the poultry industry. This large scale use presents an opportunity to observe nutrigenomic effects of prolonged use of herbs on a substantial number of birds fed high concentrations of these products throughout the production cycle. In this manuscript, we investigated the transcriptional effect of continual prolonged oregano supplementation on chicken ileum gene expression. Based on ileum transcriptomics, we report that continual supplementation with 2% oregano altered microbiota-gut-brain axis signalling, rearranged cancer susceptibility towards reduced steroid hormone-related cancers and altered expression of genes targeted by many registered drugs, thus likely affecting their efficiency and side effects. Transcriptional toxicology analysis indicated significant activation of Ventricular Septal Defect and Congenital Heart Disease categories. Our results, counter the notion that natural products such as oregano have the potential for little to no side-effects as they are “natural”. The nutrigenomic approach of understanding benefits and side effects of the food we eat, can revolutionize disease management and therapy and have special significance in designing the diets for individuals or livestock with known disease predispositions.", publisher = "Royal Society of Chemistry", journal = "Food and Function", title = "Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis", volume = "12", number = "2", pages = "726-738", doi = "10.1039/d0fo02988b" }
Bajagai, Y. S., Steel, J. C., Radovanovic, A.,& Stanley, D.. (2021). Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis. in Food and Function Royal Society of Chemistry., 12(2), 726-738. https://doi.org/10.1039/d0fo02988b
Bajagai YS, Steel JC, Radovanovic A, Stanley D. Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis. in Food and Function. 2021;12(2):726-738. doi:10.1039/d0fo02988b .
Bajagai, Yadav S., Steel, Jason C., Radovanovic, Anita, Stanley, Dragana, "Prolonged continual consumption of oregano herb interferes with the action of steroid hormones and several drugs, and effects signaling across the brain-gut axis" in Food and Function, 12, no. 2 (2021):726-738, https://doi.org/10.1039/d0fo02988b . .