Humoral immunity in puppies of immune bitches vaccinated with an attenuated and inactivated

Abstract

In order to examine the humoral immune response to a vaccine against canine parvoviruses in puppies of immune bitches, vaccinated during gravidity, an experiment was performed on a total of 56 puppies from 10 litters, which were vaccinated three times, on the 7th, 11th, and 17th weeks of life. One group of puppies was vaccinated with an attenuated vaccine, while another was vaccinated with an inactivated vaccine. The titer of maternal antibodies and the vaccine - induced titer of specific antibodies were examined using the IHA test. The titer of maternal antibodies in puppies before the first vaccination ranged from lt 20 to 1:80. Following vaccination, we established an expected increase in the titer of specific antibodies, over 1:160 without more significant differences between the two types of vaccines.

U cilju ispitivanja humoralnog imunog odgovora na vakcinu protiv parvovirusa pasa kod štenadi koja potiču od imunih kuja, vakcinisanih tokom graviditeta izveden je ogled na ukupno 56 štenadi iz 10 legala, koja su bila podvrgnuta trokratnoj vakcinaciji u 7, 11. i 17. nedelji života. Jedna grupa štenadi je, pri tome, vakcinisana atenuiranom vakcinom, dok je štenad druge grupe vakcinisana inaktivisanom vakcinom. Titar maternalnih antitela, zatim vakcinalni titar specifičnih antitela ispitivan je metodom IHA testa. Titar maternalnih antitela kod štenadi pre prve vakcinacije bio je u intervalu od 20 do 1:80. Posle vakcinacije je utvrđeno očekivano povećanje titra specifičnih antitela, više od 1:160, bez značajnih razlika između dva tipa vakcine.