Humoral immunity of pregnant bitches, vaccinated with inactivated vaccine against parvoviral infections in dogs

Abstract

Parvoviral infections are a big medical and economic problem, in particular in large dog-breeding facilities. Having in mind the manner in which this infection is spread (fecal-oral pathways), and the strong resistence of parvoviruses to the outer environment, general and immunoprophylaxis have a significant role in the control of this dangerous disease. This work examines the humoral immunological response of pregnant bitches, vaccinated with an inactivated vaccine against parvoviral infection in dogs. An experiment was performed on 10 pregnant bitches which were vaccinated on the 42nd day of gravidity with an inactivated vaccine, and an IHA test proved the lowest titer of antibodies was 1:1280, and the highest 1:20480. The titer of pregnant bitches before vaccination ranged from 1:80 to 1:320. These investigations indicate that puppies of vaccinated bitches receive the corresponding level of immunoglobulin through colostrum, and are protected from parvoviral infection in the first 6-7 weeks of life.

Parvovirusna infekcija predstavlja veliki zdravstveni i ekonomski problem posebno u velikim odgajivačnicama pasa. S obzirom na način širenja infekcije (fekalno-oralni put) i veliku otpornost parvovirusa u spoljašnjoj sredini značajnu ulogu u kontroli ove opasne bolesti predstavlja opšta i imunoprofilaksa. Takođe, veliki značaj se pridaje vakcinaciji gravidnih kuja inaktivisanom vakcinom. U radu je ispitivan humoralni imunološki odgovor gravidnih kuja, vakcinisanih inaktivisanom vakcinom protiv parvovirusne infekcije pasa. Ogled je izveden na 10 gravidnih kuja koje su vakcinisane 42. dana graviditeta inaktivisanom vakcinom, a IHA testom je dokazano da je najniži titar antitela 1:1280, a najviši 1:20480. Prevakcinalni titar gravidnih kuja bio je od 1:80 do 1:320. Ova ispitivanja ukazuju da će štenad koja potiču od vakcinisanih kuja, kolostrumom dobiti odgovarajući nivo imunoglobulina i biti zaštićena od parvovirusne infekcije u prvih 6-7 nedelja života.