The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury
2021
Аутори
Dragašević, N.Jakovljević, V.
Živković, V.
Draginić, N.
Anđić, M.
Bolevich, S.
Jović, Slavoljub
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Myocardial ischaemia–reperfusion (I/R) injury is a well-known term for exacerbation of cellular destruction and dysfunction after the restoration of blood flow to a previously ischaemic heart. A vast number of studies that have demonstrated that the role of mineralocorticoids in cardiovascular diseases is based on the use of pharmacological mineralocorticoid receptor (MR) antagonists. This review paper aimed to summarize current knowledge on the effects of MR antagonists on myocardial I/R injury as well as postinfarction remodeling. Animal models, predominantly the Langendorff technique and left anterior descending coronary artery occlusion, have confirmed the potency of MR antagonists as preconditioning and postconditioning agents in limiting infarct size and postinfarction remodeling. Several preclinical studies in rodents have established and proved possible mechanisms of cardioprotection by MR antagonists, such as reduction of oxidative stress, reduction of inflammation, and apopto...sis, therefore limiting the infarct zone. However, the results of some clinical trials are inconsistent, since they reported no benefit of MR antagonists in acute myocardial infarction. Due to this, further studies and the results of ongoing clinical trials regarding MR antagonist administration in patients with acute myocardial infarction are being awaited with great interest.
Кључне речи:
Aldosterone inhibitors / Animal models / Clinical models / Ischemia / ReperfusionИзвор:
Canadian Journal of Physiology and Pharmacology, 2021, 99, 1, 18-29Издавач:
- NRC Research Press (Canadian Science Publishing)
Напомена:
- This is the peer-reviewed version of the article: Dragasevic, N.; Jakovljevic, V.; Zivkovic, V.; Draginic, N.; Andjic, M.; Bolevich, S.; Jovic, S. The Role of Aldosterone Inhibitors in Cardiac Ischemia–Reperfusion Injury. Can. J. Physiol. Pharmacol. 2021, 99 (1), 18–29. https://doi.org/10.1139/cjpp-2020-0276
Повезане информације:
- Друга верзија
https://doi.org/10.1139/cjpp-2020-0276
DOI: 10.1139/cjpp-2020-0276
ISSN: 0008-4212
WoS: 000613249900003
Scopus: 2-s2.0-85099808234
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Dragašević, N. AU - Jakovljević, V. AU - Živković, V. AU - Draginić, N. AU - Anđić, M. AU - Bolevich, S. AU - Jović, Slavoljub PY - 2021 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2042 AB - Myocardial ischaemia–reperfusion (I/R) injury is a well-known term for exacerbation of cellular destruction and dysfunction after the restoration of blood flow to a previously ischaemic heart. A vast number of studies that have demonstrated that the role of mineralocorticoids in cardiovascular diseases is based on the use of pharmacological mineralocorticoid receptor (MR) antagonists. This review paper aimed to summarize current knowledge on the effects of MR antagonists on myocardial I/R injury as well as postinfarction remodeling. Animal models, predominantly the Langendorff technique and left anterior descending coronary artery occlusion, have confirmed the potency of MR antagonists as preconditioning and postconditioning agents in limiting infarct size and postinfarction remodeling. Several preclinical studies in rodents have established and proved possible mechanisms of cardioprotection by MR antagonists, such as reduction of oxidative stress, reduction of inflammation, and apoptosis, therefore limiting the infarct zone. However, the results of some clinical trials are inconsistent, since they reported no benefit of MR antagonists in acute myocardial infarction. Due to this, further studies and the results of ongoing clinical trials regarding MR antagonist administration in patients with acute myocardial infarction are being awaited with great interest. PB - NRC Research Press (Canadian Science Publishing) T2 - Canadian Journal of Physiology and Pharmacology T1 - The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury VL - 99 IS - 1 SP - 18 EP - 29 EP - DO - 10.1139/cjpp-2020-0276 ER -
@article{ author = "Dragašević, N. and Jakovljević, V. and Živković, V. and Draginić, N. and Anđić, M. and Bolevich, S. and Jović, Slavoljub", year = "2021", abstract = "Myocardial ischaemia–reperfusion (I/R) injury is a well-known term for exacerbation of cellular destruction and dysfunction after the restoration of blood flow to a previously ischaemic heart. A vast number of studies that have demonstrated that the role of mineralocorticoids in cardiovascular diseases is based on the use of pharmacological mineralocorticoid receptor (MR) antagonists. This review paper aimed to summarize current knowledge on the effects of MR antagonists on myocardial I/R injury as well as postinfarction remodeling. Animal models, predominantly the Langendorff technique and left anterior descending coronary artery occlusion, have confirmed the potency of MR antagonists as preconditioning and postconditioning agents in limiting infarct size and postinfarction remodeling. Several preclinical studies in rodents have established and proved possible mechanisms of cardioprotection by MR antagonists, such as reduction of oxidative stress, reduction of inflammation, and apoptosis, therefore limiting the infarct zone. However, the results of some clinical trials are inconsistent, since they reported no benefit of MR antagonists in acute myocardial infarction. Due to this, further studies and the results of ongoing clinical trials regarding MR antagonist administration in patients with acute myocardial infarction are being awaited with great interest.", publisher = "NRC Research Press (Canadian Science Publishing)", journal = "Canadian Journal of Physiology and Pharmacology", title = "The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury", volume = "99", number = "1", pages = "18-29-", doi = "10.1139/cjpp-2020-0276" }
Dragašević, N., Jakovljević, V., Živković, V., Draginić, N., Anđić, M., Bolevich, S.,& Jović, S.. (2021). The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury. in Canadian Journal of Physiology and Pharmacology NRC Research Press (Canadian Science Publishing)., 99(1), 18-29. https://doi.org/10.1139/cjpp-2020-0276
Dragašević N, Jakovljević V, Živković V, Draginić N, Anđić M, Bolevich S, Jović S. The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury. in Canadian Journal of Physiology and Pharmacology. 2021;99(1):18-29. doi:10.1139/cjpp-2020-0276 .
Dragašević, N., Jakovljević, V., Živković, V., Draginić, N., Anđić, M., Bolevich, S., Jović, Slavoljub, "The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury" in Canadian Journal of Physiology and Pharmacology, 99, no. 1 (2021):18-29, https://doi.org/10.1139/cjpp-2020-0276 . .