Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning
Dijagnostička vrednost tri jednostavna i brza testa za suvo oko – nabori konjunktive paralelni ivici kapka, visina meniskusa suza i test grananja suza
Апстракт
Introduction/Objective The objective of this paper was to assess the diagnostic value of three simple dry eye (DE) tests: lid parallel conjunctival folds (LIPCOF), tear meniscus height (TMH), and tear ferning (TF). Methods LIPCOF, TMH, and TF diagnostic DE tests were performed in 100 patients. Eighty of them were referred to us by rheumatologists and general practitioners either during evaluation for Sjögren’s syndrome, or because of DE symptoms. The control group was composed of 20 patients, with no DE-related symptoms. Ocular Surface Disease Index questionnaire was used for DE symptoms’ evaluation. Results of LIPCOF, TMH, and TF tests were compared with results of the Copenhagen criteria DE tests i.e., tear fluorescein breakup time, Schirmer I and Rose Bengal tests. Ability of the tests to recognize DE in various grades according to Dry Eye Work Shop (DEWS) report score system was assessed. Results Compared to the Copenhagen criteria, sensitivity of LIPCOF and TMH was high (92.8% and... 83.5%, respectively), while specificity was low (34.4% and 49.2%, respectively). TF had low sensitivity (59.1%) but high specificity (82.7%). Mean values of both LIPCOF and TMH differed significantly (F = 7.222, p < 0.001 and F = 11.802, p < 0.001, respectively) between the control group and all DEWS grades, but not among different grades of DE. Conclusion TMH and LIPCOF diagnostic tests showed high sensitivity, which makes them excellent screening DE tests. Low sensitivity of TF suggests that it is not truly a good screening test on its own, but its high specificity is of definite value.
Uvod/Cilj Cilj ovog rada je da se proceni dijagnostička vrednost tri jednostavna testa za suvo oko: nabori konjunk- tive paralelni ivici kapka (NKPIK), visina meniskusa suza (VMS) i test grananja suze (GS). Metode Dijagnostički testovi NKPIK, VMS i GS su izvedeni kod 100 pacijenata, od kojih nam je 80 upućeno na pregled od strane reumatologa i nadležnih oftalmologa, tokom ispitivanja na Sjogrenov sindrom ili zbog simptoma suvog oka. Kontrolnu grupu je činilo 20 pacijenata bez simptoma suvog oka. Simptomi su evaluirani primenom upitnika o indeksu bolesti površine oka. Rezultati testova NKPIK, VMS i GS su upoređeni sa vrednostima rezultata testova za suvo oko po Kopenhaškim kriterijumima, a to su: vreme prekida suznog filma obojenog fluoresceinom, merenje sekrecije suza bez anestezije tokom pet minuta Šimero- vom trakom (Schirmer I) i bojenje površine oka vitalnom bojom Rose Bengal. Takođe je procenjena sposobnost testova da prepoznaju različite stadijume po sistemu gradiranja bolesti Dr...y Eye Work Shop (DEWS). Rezultati Poređenjem sa grupom testova po Kopenhaškim kriterijumima, NKPIK i VMS su pokazali visoku senzitiv- nost (92,8% i 83,5%), dok im je specifičnost bila niska (34,4% i 49,2%). GS je imao nisku senzitivnost (59,1%), ali visoku specifičnost (82,7%). Prosečne vrednosti testova NKPIK i VMS se statistički značajno razlikuju između kon- trolne grupe i svih stadijuma bolesti po gradaciji DEWS, ali ne i između različitih stadijuma bolesti suvog oka. Zaključak Testovi VMS i NKPIK su pokazali visoku senzi- tivnost, što ih čini odličnim testovima za skrining bole- sti suvog oka. Niska senzitivnost testa GS ga ne svrstava u dobre skrining testove, ali njegova visoka specifičnost mu daje dijagnostičku vrednost.
Кључне речи:
Dry eye disease / Lid Parallel Conjunctival Folds / Tear Meniscus Height / Tear Ferning / bolest suvog oka / nabori konjunktive paralelni ivici kapka / visina meniskusa suza / test grananja suzeИзвор:
Srpski arhiv za celokupno lekarstvo, 2021, 149, 3-4, 196-201Издавач:
- Serbian Medical Society
Напомена:
- This paper is a part of a doctoral thesis: Dačić-Krnjaja B. Diagnostic value of group of simple and rapid tests for dry eye diseases (dissertation). Belgrade, University of Belgrade; 2018.
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Dačić-Krnjaja, Bojana AU - Hadži-Milić, Milan AU - Potić, Jelena AU - Raonić, Danijela AU - Stojković, Milenko PY - 2021 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2070 AB - Introduction/Objective The objective of this paper was to assess the diagnostic value of three simple dry eye (DE) tests: lid parallel conjunctival folds (LIPCOF), tear meniscus height (TMH), and tear ferning (TF). Methods LIPCOF, TMH, and TF diagnostic DE tests were performed in 100 patients. Eighty of them were referred to us by rheumatologists and general practitioners either during evaluation for Sjögren’s syndrome, or because of DE symptoms. The control group was composed of 20 patients, with no DE-related symptoms. Ocular Surface Disease Index questionnaire was used for DE symptoms’ evaluation. Results of LIPCOF, TMH, and TF tests were compared with results of the Copenhagen criteria DE tests i.e., tear fluorescein breakup time, Schirmer I and Rose Bengal tests. Ability of the tests to recognize DE in various grades according to Dry Eye Work Shop (DEWS) report score system was assessed. Results Compared to the Copenhagen criteria, sensitivity of LIPCOF and TMH was high (92.8% and 83.5%, respectively), while specificity was low (34.4% and 49.2%, respectively). TF had low sensitivity (59.1%) but high specificity (82.7%). Mean values of both LIPCOF and TMH differed significantly (F = 7.222, p < 0.001 and F = 11.802, p < 0.001, respectively) between the control group and all DEWS grades, but not among different grades of DE. Conclusion TMH and LIPCOF diagnostic tests showed high sensitivity, which makes them excellent screening DE tests. Low sensitivity of TF suggests that it is not truly a good screening test on its own, but its high specificity is of definite value. AB - Uvod/Cilj Cilj ovog rada je da se proceni dijagnostička vrednost tri jednostavna testa za suvo oko: nabori konjunk- tive paralelni ivici kapka (NKPIK), visina meniskusa suza (VMS) i test grananja suze (GS). Metode Dijagnostički testovi NKPIK, VMS i GS su izvedeni kod 100 pacijenata, od kojih nam je 80 upućeno na pregled od strane reumatologa i nadležnih oftalmologa, tokom ispitivanja na Sjogrenov sindrom ili zbog simptoma suvog oka. Kontrolnu grupu je činilo 20 pacijenata bez simptoma suvog oka. Simptomi su evaluirani primenom upitnika o indeksu bolesti površine oka. Rezultati testova NKPIK, VMS i GS su upoređeni sa vrednostima rezultata testova za suvo oko po Kopenhaškim kriterijumima, a to su: vreme prekida suznog filma obojenog fluoresceinom, merenje sekrecije suza bez anestezije tokom pet minuta Šimero- vom trakom (Schirmer I) i bojenje površine oka vitalnom bojom Rose Bengal. Takođe je procenjena sposobnost testova da prepoznaju različite stadijume po sistemu gradiranja bolesti Dry Eye Work Shop (DEWS). Rezultati Poređenjem sa grupom testova po Kopenhaškim kriterijumima, NKPIK i VMS su pokazali visoku senzitiv- nost (92,8% i 83,5%), dok im je specifičnost bila niska (34,4% i 49,2%). GS je imao nisku senzitivnost (59,1%), ali visoku specifičnost (82,7%). Prosečne vrednosti testova NKPIK i VMS se statistički značajno razlikuju između kon- trolne grupe i svih stadijuma bolesti po gradaciji DEWS, ali ne i između različitih stadijuma bolesti suvog oka. Zaključak Testovi VMS i NKPIK su pokazali visoku senzi- tivnost, što ih čini odličnim testovima za skrining bole- sti suvog oka. Niska senzitivnost testa GS ga ne svrstava u dobre skrining testove, ali njegova visoka specifičnost mu daje dijagnostičku vrednost. PB - Serbian Medical Society T2 - Srpski arhiv za celokupno lekarstvo T2 - Srpski arhiv za celokupno lekarstvo T1 - Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning T1 - Dijagnostička vrednost tri jednostavna i brza testa za suvo oko – nabori konjunktive paralelni ivici kapka, visina meniskusa suza i test grananja suza VL - 149 IS - 3-4 SP - 196 EP - 201 DO - 10.2298/SARH190829024D ER -
@article{ author = "Dačić-Krnjaja, Bojana and Hadži-Milić, Milan and Potić, Jelena and Raonić, Danijela and Stojković, Milenko", year = "2021", abstract = "Introduction/Objective The objective of this paper was to assess the diagnostic value of three simple dry eye (DE) tests: lid parallel conjunctival folds (LIPCOF), tear meniscus height (TMH), and tear ferning (TF). Methods LIPCOF, TMH, and TF diagnostic DE tests were performed in 100 patients. Eighty of them were referred to us by rheumatologists and general practitioners either during evaluation for Sjögren’s syndrome, or because of DE symptoms. The control group was composed of 20 patients, with no DE-related symptoms. Ocular Surface Disease Index questionnaire was used for DE symptoms’ evaluation. Results of LIPCOF, TMH, and TF tests were compared with results of the Copenhagen criteria DE tests i.e., tear fluorescein breakup time, Schirmer I and Rose Bengal tests. Ability of the tests to recognize DE in various grades according to Dry Eye Work Shop (DEWS) report score system was assessed. Results Compared to the Copenhagen criteria, sensitivity of LIPCOF and TMH was high (92.8% and 83.5%, respectively), while specificity was low (34.4% and 49.2%, respectively). TF had low sensitivity (59.1%) but high specificity (82.7%). Mean values of both LIPCOF and TMH differed significantly (F = 7.222, p < 0.001 and F = 11.802, p < 0.001, respectively) between the control group and all DEWS grades, but not among different grades of DE. Conclusion TMH and LIPCOF diagnostic tests showed high sensitivity, which makes them excellent screening DE tests. Low sensitivity of TF suggests that it is not truly a good screening test on its own, but its high specificity is of definite value., Uvod/Cilj Cilj ovog rada je da se proceni dijagnostička vrednost tri jednostavna testa za suvo oko: nabori konjunk- tive paralelni ivici kapka (NKPIK), visina meniskusa suza (VMS) i test grananja suze (GS). Metode Dijagnostički testovi NKPIK, VMS i GS su izvedeni kod 100 pacijenata, od kojih nam je 80 upućeno na pregled od strane reumatologa i nadležnih oftalmologa, tokom ispitivanja na Sjogrenov sindrom ili zbog simptoma suvog oka. Kontrolnu grupu je činilo 20 pacijenata bez simptoma suvog oka. Simptomi su evaluirani primenom upitnika o indeksu bolesti površine oka. Rezultati testova NKPIK, VMS i GS su upoređeni sa vrednostima rezultata testova za suvo oko po Kopenhaškim kriterijumima, a to su: vreme prekida suznog filma obojenog fluoresceinom, merenje sekrecije suza bez anestezije tokom pet minuta Šimero- vom trakom (Schirmer I) i bojenje površine oka vitalnom bojom Rose Bengal. Takođe je procenjena sposobnost testova da prepoznaju različite stadijume po sistemu gradiranja bolesti Dry Eye Work Shop (DEWS). Rezultati Poređenjem sa grupom testova po Kopenhaškim kriterijumima, NKPIK i VMS su pokazali visoku senzitiv- nost (92,8% i 83,5%), dok im je specifičnost bila niska (34,4% i 49,2%). GS je imao nisku senzitivnost (59,1%), ali visoku specifičnost (82,7%). Prosečne vrednosti testova NKPIK i VMS se statistički značajno razlikuju između kon- trolne grupe i svih stadijuma bolesti po gradaciji DEWS, ali ne i između različitih stadijuma bolesti suvog oka. Zaključak Testovi VMS i NKPIK su pokazali visoku senzi- tivnost, što ih čini odličnim testovima za skrining bole- sti suvog oka. Niska senzitivnost testa GS ga ne svrstava u dobre skrining testove, ali njegova visoka specifičnost mu daje dijagnostičku vrednost.", publisher = "Serbian Medical Society", journal = "Srpski arhiv za celokupno lekarstvo, Srpski arhiv za celokupno lekarstvo", title = "Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning, Dijagnostička vrednost tri jednostavna i brza testa za suvo oko – nabori konjunktive paralelni ivici kapka, visina meniskusa suza i test grananja suza", volume = "149", number = "3-4", pages = "196-201", doi = "10.2298/SARH190829024D" }
Dačić-Krnjaja, B., Hadži-Milić, M., Potić, J., Raonić, D.,& Stojković, M.. (2021). Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning. in Srpski arhiv za celokupno lekarstvo Serbian Medical Society., 149(3-4), 196-201. https://doi.org/10.2298/SARH190829024D
Dačić-Krnjaja B, Hadži-Milić M, Potić J, Raonić D, Stojković M. Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning. in Srpski arhiv za celokupno lekarstvo. 2021;149(3-4):196-201. doi:10.2298/SARH190829024D .
Dačić-Krnjaja, Bojana, Hadži-Milić, Milan, Potić, Jelena, Raonić, Danijela, Stojković, Milenko, "Diagnostic value of three simple and rapid dry eye tests: Lid parallel conjunctival folds, tear meniscus height and tear ferning" in Srpski arhiv za celokupno lekarstvo, 149, no. 3-4 (2021):196-201, https://doi.org/10.2298/SARH190829024D . .