Markeri značajni za prognozu i terapiju tumora pasa
Prognostic markers significant for therapy of tumours in dogs
Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт
Višestruki onkogeni efekti utiču na inhibiciju maturacije ćelije, migraciju i tkivnu invaziju. Razvoj tumora podrazumeva nesklad između proliferacije, rasta i diferencijacije, što je praćeno značajnim genotipskim i fenotipskim varijacijama. Kvalitativno i kvantitativno određivanje bioloških prognostičkih faktora u tkivu govori o metastatskom potencijalu tumora i predikciji neoplastične bolesti. Faktore angiogeneze i brojne aktivirajuće i inhibitorne proteine moguće je imunohistohemijski dokazati u tkivu tumora, a imunofenotipizacija limfoma je nužna za izbor terapijskog protokola. Određivanje proliferativnog potencijala tumorskih ćelija imunohistohemijskom detekcijom PCNA, Ki-67, CD-117, CD45 koristi se u gradiranju mastocitoma. Sve je značajnija klinička korelacija rasta tumora sa ekspresijom različitih antigena na tumorskim ćelijama.
The multiple oncogenic effects on the inhibition of cell maturation, on cell migration and tissue invasion,
is responsible for the occurrence of tumours. The development of tumours implies a disproportion between
proliferation, growth and differentiation, which is accompanied by significant genotypic and phenotypic
variations in the diseased. The qualitative and quantitative determination of the biological prognostic factors
in the tissue indicates possible tumour metastasizing, and consequently also the prognosis of the neoplastic
disease. It is possible immunohistochemically to prove factors of angiogenesis and numerous activating and
inhibiting proteins in the tumour tissue, which is also very important for properly choice of lymphoma
therapy. The determination of the proliferative potential of tumour cells by immunohistochemical detection of
PCNA, Ki-67, CD-117, CD 45, is used in grading of mast cell tumours. In addition to other histological,
clinical and biological param...eters, they are significant for the further prognosis and therapy of neoplasms.
Кључне речи:
tumori pasa / markeri / prognoza / tumours / dogs / prognostic markersИзвор:
Veterinarski žurnal Republike Srpske, 2012, 12, 1, 34-38Издавач:
- Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
Финансирање / пројекти:
- Молекуларно-генетичка и екофизиолошка истраживања у заштити аутохтоних анималних генетичких ресурса, очувању добробити, здравља и репродукције гајених животиња и производњи безбедне хране (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Aleksić-Kovačević, Sanja AU - Marinković, Darko AU - Vučićević, Ivana PY - 2012 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2092 AB - Višestruki onkogeni efekti utiču na inhibiciju maturacije ćelije, migraciju i tkivnu invaziju. Razvoj tumora podrazumeva nesklad između proliferacije, rasta i diferencijacije, što je praćeno značajnim genotipskim i fenotipskim varijacijama. Kvalitativno i kvantitativno određivanje bioloških prognostičkih faktora u tkivu govori o metastatskom potencijalu tumora i predikciji neoplastične bolesti. Faktore angiogeneze i brojne aktivirajuće i inhibitorne proteine moguće je imunohistohemijski dokazati u tkivu tumora, a imunofenotipizacija limfoma je nužna za izbor terapijskog protokola. Određivanje proliferativnog potencijala tumorskih ćelija imunohistohemijskom detekcijom PCNA, Ki-67, CD-117, CD45 koristi se u gradiranju mastocitoma. Sve je značajnija klinička korelacija rasta tumora sa ekspresijom različitih antigena na tumorskim ćelijama. AB - The multiple oncogenic effects on the inhibition of cell maturation, on cell migration and tissue invasion, is responsible for the occurrence of tumours. The development of tumours implies a disproportion between proliferation, growth and differentiation, which is accompanied by significant genotypic and phenotypic variations in the diseased. The qualitative and quantitative determination of the biological prognostic factors in the tissue indicates possible tumour metastasizing, and consequently also the prognosis of the neoplastic disease. It is possible immunohistochemically to prove factors of angiogenesis and numerous activating and inhibiting proteins in the tumour tissue, which is also very important for properly choice of lymphoma therapy. The determination of the proliferative potential of tumour cells by immunohistochemical detection of PCNA, Ki-67, CD-117, CD 45, is used in grading of mast cell tumours. In addition to other histological, clinical and biological parameters, they are significant for the further prognosis and therapy of neoplasms. PB - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“ T2 - Veterinarski žurnal Republike Srpske T1 - Markeri značajni za prognozu i terapiju tumora pasa T1 - Prognostic markers significant for therapy of tumours in dogs VL - 12 IS - 1 SP - 34 EP - 38 UR - https://hdl.handle.net/21.15107/rcub_veterinar_2092 ER -
@article{ author = "Aleksić-Kovačević, Sanja and Marinković, Darko and Vučićević, Ivana", year = "2012", abstract = "Višestruki onkogeni efekti utiču na inhibiciju maturacije ćelije, migraciju i tkivnu invaziju. Razvoj tumora podrazumeva nesklad između proliferacije, rasta i diferencijacije, što je praćeno značajnim genotipskim i fenotipskim varijacijama. Kvalitativno i kvantitativno određivanje bioloških prognostičkih faktora u tkivu govori o metastatskom potencijalu tumora i predikciji neoplastične bolesti. Faktore angiogeneze i brojne aktivirajuće i inhibitorne proteine moguće je imunohistohemijski dokazati u tkivu tumora, a imunofenotipizacija limfoma je nužna za izbor terapijskog protokola. Određivanje proliferativnog potencijala tumorskih ćelija imunohistohemijskom detekcijom PCNA, Ki-67, CD-117, CD45 koristi se u gradiranju mastocitoma. Sve je značajnija klinička korelacija rasta tumora sa ekspresijom različitih antigena na tumorskim ćelijama., The multiple oncogenic effects on the inhibition of cell maturation, on cell migration and tissue invasion, is responsible for the occurrence of tumours. The development of tumours implies a disproportion between proliferation, growth and differentiation, which is accompanied by significant genotypic and phenotypic variations in the diseased. The qualitative and quantitative determination of the biological prognostic factors in the tissue indicates possible tumour metastasizing, and consequently also the prognosis of the neoplastic disease. It is possible immunohistochemically to prove factors of angiogenesis and numerous activating and inhibiting proteins in the tumour tissue, which is also very important for properly choice of lymphoma therapy. The determination of the proliferative potential of tumour cells by immunohistochemical detection of PCNA, Ki-67, CD-117, CD 45, is used in grading of mast cell tumours. In addition to other histological, clinical and biological parameters, they are significant for the further prognosis and therapy of neoplasms.", publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“", journal = "Veterinarski žurnal Republike Srpske", title = "Markeri značajni za prognozu i terapiju tumora pasa, Prognostic markers significant for therapy of tumours in dogs", volume = "12", number = "1", pages = "34-38", url = "https://hdl.handle.net/21.15107/rcub_veterinar_2092" }
Aleksić-Kovačević, S., Marinković, D.,& Vučićević, I.. (2012). Markeri značajni za prognozu i terapiju tumora pasa. in Veterinarski žurnal Republike Srpske Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 12(1), 34-38. https://hdl.handle.net/21.15107/rcub_veterinar_2092
Aleksić-Kovačević S, Marinković D, Vučićević I. Markeri značajni za prognozu i terapiju tumora pasa. in Veterinarski žurnal Republike Srpske. 2012;12(1):34-38. https://hdl.handle.net/21.15107/rcub_veterinar_2092 .
Aleksić-Kovačević, Sanja, Marinković, Darko, Vučićević, Ivana, "Markeri značajni za prognozu i terapiju tumora pasa" in Veterinarski žurnal Republike Srpske, 12, no. 1 (2012):34-38, https://hdl.handle.net/21.15107/rcub_veterinar_2092 .