Klinička i histopatološka ispitivanja limfocitno-plazmocitnog duodenitisa pasa

Abstract

Hronična oboljenja tankih creva pasa su ređa od akutnih poremećaja i samim tim teže se dijagnostikuju. Među ova oboljenja spada idiopatsko zapaljenje tankih creva, koje se odlikuje infi ltracijom ćelija infl amacije unutar l. propriae tankih creva, tunike mukoze tankih creva. Na osnovu kliničke slike i opšteg kliničkog pregleda moguće je postaviti sumnju. Analizom krvne slike pasa zapaža se leukocitoza i limfocitoza, dok se biohemijskim analizama može utvrditi različit stepen hipoproteinemije i hipoalbuminemije. Specijalističkim pregledom creva endoskopom može se uočiti različit stepen promena na sluznici tankih creva, od blagog edema do ulceracija. Tek nakon biopsije sluznice tankih creva i histopatološkog pregleda moguće je postaviti dijagnozu limfocitno-plazmocitnog duodenitisa. Iako je dijagnoza poznata, etiologija ovog oboljenja nije u potpunosti poznata, tako da je za postavljanje defi nitivne dijagnoze potrebno isključiti sva druga oboljenja sa istim ili sličnim simptomima. Tokom ovog istraživanja sprovedenog na gastroenterološkim pacijentima ambulante Klinike za male životinje Fakulteta veterinarske medicine u Beogradu tokom oktobra, novembra i decembra 2011. godine, kod četrnaest pacijenata je dijagnostikovan hronični limfocitno-plazmocitni enteritis i limfocitni enteritis.

Chronic diseases of the small intestine are less common than acute disorders and therefore they are harder to diagnose. They can easily be mistaken with the diseases which give similar or same symptoms, which are chronic diarrhea, chronic vomiting, followed by weight loss due to malabsorption or protein loss trough digestive system. One of these diseases is idiopathic infl ammatory bowel disease, which is characterized by infi ltration of infl ammatory cells within the lamina propria in tunica mucosa of small bowel. Based on clinical signs and general physical examination, it is possible to place a suspicion to this disease, but by blood analyses leukocytosis can be identifi ed, while by biochemical analysis a different degree of hypoproteinemia can be found. Endoscopy examination of digestive tube different degree of changes on small bowel mucosa, from mild edema to severe ulceration can be found. A defi nitive diagnosis of IBD can only be made based on intestinal biopsy specimen analysis. Although the diagnosis is known, etiology of this disease is unknown, so it is necessary to exclude all other diseases with the same or similar symptoms for defi nitive diagnosis. During this research we used results of gastroenterological patients from Clinic for small animals of the Faculty of Veterinary medicine in Belgrade in October, November and December of 2011, with chronic plasmocitic enteritis was diagnosed 14 patients.