SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP
Genetski deverzitet u okviru fragmenta gena myo15a, odgovornog za sluh u populaciji životinja familije canidae u uslovima farmskog i slobodnog uzgoja
Аутори
Andrzej, JakubczakMagdalena, Gryzinska
Beata, Horecka
Katarzyna, Dziadosz
Grazyna, Jezewska-Witkowska
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial influence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family.
Gen MYO15A je uključen u stvaranje proteina iz grupe motornih proteina - miozina. Miozin XVA je lociran u unutrašnjem uhu, hipofi zi i drugim tkivima, i značajno utiče na slušni proces. Mutacije u ovom genu izazivaju supstitucije aminokiselina u konzervisanom motornom domenu lanca miozina, što dovodi do skraćenja stereocilija slušnih ćelija, a kao posledica dolazi do poremećaja funkcije XVA miozina. Postavljena je istraživačka hipoteza koja je pretpostavljala da mutacije u genu koji je odgovoran za slušni proces kod životinja familije Canidae mogu da izazovu hipoakustiku kao i značajne promene u ponašanju pasa, od povučenosti i straha do agresivnosti. Ispitivanjem je determinisan SNP polimorfi zam u fragmentu gena MYO15A koji može da dovede do poremećaja sluha kako kod divljih tako i kod farmski uzgajanih životinja familije Canidae.
Кључне речи:
fox / mutation / MYO15A gene / raccoon dog / SNP haplotypeИзвор:
Acta Veterinaria-Beograd, 2014, 64, 3, 358-366Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Andrzej, Jakubczak AU - Magdalena, Gryzinska AU - Beata, Horecka AU - Katarzyna, Dziadosz AU - Grazyna, Jezewska-Witkowska PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2136 AB - The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial influence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family. AB - Gen MYO15A je uključen u stvaranje proteina iz grupe motornih proteina - miozina. Miozin XVA je lociran u unutrašnjem uhu, hipofi zi i drugim tkivima, i značajno utiče na slušni proces. Mutacije u ovom genu izazivaju supstitucije aminokiselina u konzervisanom motornom domenu lanca miozina, što dovodi do skraćenja stereocilija slušnih ćelija, a kao posledica dolazi do poremećaja funkcije XVA miozina. Postavljena je istraživačka hipoteza koja je pretpostavljala da mutacije u genu koji je odgovoran za slušni proces kod životinja familije Canidae mogu da izazovu hipoakustiku kao i značajne promene u ponašanju pasa, od povučenosti i straha do agresivnosti. Ispitivanjem je determinisan SNP polimorfi zam u fragmentu gena MYO15A koji može da dovede do poremećaja sluha kako kod divljih tako i kod farmski uzgajanih životinja familije Canidae. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP T1 - Genetski deverzitet u okviru fragmenta gena myo15a, odgovornog za sluh u populaciji životinja familije canidae u uslovima farmskog i slobodnog uzgoja VL - 64 IS - 3 SP - 358 EP - 366 DO - 10.2478/acve-2014-0034 ER -
@article{ author = "Andrzej, Jakubczak and Magdalena, Gryzinska and Beata, Horecka and Katarzyna, Dziadosz and Grazyna, Jezewska-Witkowska", year = "2014", abstract = "The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial influence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family., Gen MYO15A je uključen u stvaranje proteina iz grupe motornih proteina - miozina. Miozin XVA je lociran u unutrašnjem uhu, hipofi zi i drugim tkivima, i značajno utiče na slušni proces. Mutacije u ovom genu izazivaju supstitucije aminokiselina u konzervisanom motornom domenu lanca miozina, što dovodi do skraćenja stereocilija slušnih ćelija, a kao posledica dolazi do poremećaja funkcije XVA miozina. Postavljena je istraživačka hipoteza koja je pretpostavljala da mutacije u genu koji je odgovoran za slušni proces kod životinja familije Canidae mogu da izazovu hipoakustiku kao i značajne promene u ponašanju pasa, od povučenosti i straha do agresivnosti. Ispitivanjem je determinisan SNP polimorfi zam u fragmentu gena MYO15A koji može da dovede do poremećaja sluha kako kod divljih tako i kod farmski uzgajanih životinja familije Canidae.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP, Genetski deverzitet u okviru fragmenta gena myo15a, odgovornog za sluh u populaciji životinja familije canidae u uslovima farmskog i slobodnog uzgoja", volume = "64", number = "3", pages = "358-366", doi = "10.2478/acve-2014-0034" }
Andrzej, J., Magdalena, G., Beata, H., Katarzyna, D.,& Grazyna, J.. (2014). SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(3), 358-366. https://doi.org/10.2478/acve-2014-0034
Andrzej J, Magdalena G, Beata H, Katarzyna D, Grazyna J. SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP. in Acta Veterinaria-Beograd. 2014;64(3):358-366. doi:10.2478/acve-2014-0034 .
Andrzej, Jakubczak, Magdalena, Gryzinska, Beata, Horecka, Katarzyna, Dziadosz, Grazyna, Jezewska-Witkowska, "SNP genetic diversity within a fragment of the gene myo15a responsible for the hearing process in a population of farmed and free-living animals of the canidae family/SNP" in Acta Veterinaria-Beograd, 64, no. 3 (2014):358-366, https://doi.org/10.2478/acve-2014-0034 . .