Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer
Ishrana inulinom kao terapija na hemopreventivne i zapaljenske markere tumorogeneze kolorektalnih kancera
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The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazine (DMH), and a group given dimethylhydrazine combined with the prebiotic (DMH+PRE). Dimethylhydrazine injection significantly (p<0.001) elevated the immunoreactivity chemopreventive markers COX-2, NFκB, iNOS, elevated serum and jejunal mucosa levels of proinfl ammatory cytokine IL-2, and decreased serum and jejunal mucosa levels of regulatory cytokine IL-10. Inulin diet intervention significantly suppressed immunoreactivity of COX- 2, NFκB, iNOS positive cells in the tunica mucosae and tela submucosae of rat colon tissue, increased levels of IL-2 and decreased levels of IL-10. By determining the chemopreventive markers COX-2, iNOS and NFkB, which can be characterized as inflammatory marke...rs, we confirmed the presence of inflammation in the colon as the number of COX-2, NFkB and iNOS immunoreactive cells was significantly higher after DMH application than in the control group. These findings indicate that dietary intake of inulin suppressed the expression of the observed markers, which play an important role in carcinogenesis and inflammation, which predispose the use of inulin in
Кључне речи:
Colon cancer / Sprague-Dawley rats / Inulin / Chemoprevention / InflammationИзвор:
Acta Veterinaria-Beograd, 2014, 64, 4, 519-525Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
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Fakultet veterinarske medicineTY - JOUR AU - Emília, Hijová AU - Viktoria, Szabadosova AU - Jana, Štofilová AU - Rastislav, Salaj AU - Alojz, Bomba PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2142 AB - The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazine (DMH), and a group given dimethylhydrazine combined with the prebiotic (DMH+PRE). Dimethylhydrazine injection significantly (p<0.001) elevated the immunoreactivity chemopreventive markers COX-2, NFκB, iNOS, elevated serum and jejunal mucosa levels of proinfl ammatory cytokine IL-2, and decreased serum and jejunal mucosa levels of regulatory cytokine IL-10. Inulin diet intervention significantly suppressed immunoreactivity of COX- 2, NFκB, iNOS positive cells in the tunica mucosae and tela submucosae of rat colon tissue, increased levels of IL-2 and decreased levels of IL-10. By determining the chemopreventive markers COX-2, iNOS and NFkB, which can be characterized as inflammatory markers, we confirmed the presence of inflammation in the colon as the number of COX-2, NFkB and iNOS immunoreactive cells was significantly higher after DMH application than in the control group. These findings indicate that dietary intake of inulin suppressed the expression of the observed markers, which play an important role in carcinogenesis and inflammation, which predispose the use of inulin in PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer T1 - Ishrana inulinom kao terapija na hemopreventivne i zapaljenske markere tumorogeneze kolorektalnih kancera VL - 64 IS - 4 SP - 519 EP - 525 DO - 10.2478/acve-2014-0048 ER -
@article{ author = "Emília, Hijová and Viktoria, Szabadosova and Jana, Štofilová and Rastislav, Salaj and Alojz, Bomba", year = "2014", abstract = "The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazine (DMH), and a group given dimethylhydrazine combined with the prebiotic (DMH+PRE). Dimethylhydrazine injection significantly (p<0.001) elevated the immunoreactivity chemopreventive markers COX-2, NFκB, iNOS, elevated serum and jejunal mucosa levels of proinfl ammatory cytokine IL-2, and decreased serum and jejunal mucosa levels of regulatory cytokine IL-10. Inulin diet intervention significantly suppressed immunoreactivity of COX- 2, NFκB, iNOS positive cells in the tunica mucosae and tela submucosae of rat colon tissue, increased levels of IL-2 and decreased levels of IL-10. By determining the chemopreventive markers COX-2, iNOS and NFkB, which can be characterized as inflammatory markers, we confirmed the presence of inflammation in the colon as the number of COX-2, NFkB and iNOS immunoreactive cells was significantly higher after DMH application than in the control group. These findings indicate that dietary intake of inulin suppressed the expression of the observed markers, which play an important role in carcinogenesis and inflammation, which predispose the use of inulin in", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer, Ishrana inulinom kao terapija na hemopreventivne i zapaljenske markere tumorogeneze kolorektalnih kancera", volume = "64", number = "4", pages = "519-525", doi = "10.2478/acve-2014-0048" }
Emília, H., Viktoria, S., Jana, Š., Rastislav, S.,& Alojz, B.. (2014). Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(4), 519-525. https://doi.org/10.2478/acve-2014-0048
Emília H, Viktoria S, Jana Š, Rastislav S, Alojz B. Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer. in Acta Veterinaria-Beograd. 2014;64(4):519-525. doi:10.2478/acve-2014-0048 .
Emília, Hijová, Viktoria, Szabadosova, Jana, Štofilová, Rastislav, Salaj, Alojz, Bomba, "Inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer" in Acta Veterinaria-Beograd, 64, no. 4 (2014):519-525, https://doi.org/10.2478/acve-2014-0048 . .