Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja
Influence of epinephrine and medetomidine on systemic absorption of lidocaine applied epidurally in anesthetized swine
Аутори
Marija, LiparRajka, Turner
Berislav, Radišić
Lovorka, Grgurević
Igor, Erjavec
Nataša, Brajenović
Irena, Brčić Karačonji
Marko, Samardžija
Dražen, Vnuk
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1 : 80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these tw...o adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential.
Epinefrin i alfa 2 agonisti se uvek koriste u epiduralnoj anesteziji da umanje sistemsku apsorpciju lokalnog anestetika i da produže trajanje epiduralnog bloka. U serumu svinja se određivala koncentracija lidokaina, stoga je cilj ove studije da se odredi do koje mere epinefrin i medetomidin utiču na sistemsku apsorpciju lidokaina nakon epiduralne primene. Tokom opšte anestezije prvoj grupi je epiduralno aplikovan lidokain, drugoj lidokain s epinefrinom (1: 80000), a trećoj lidokain sa medetomidinom (15 μg/ kg). Krv iz vene je uzorkovana pre, 5, 10, 20, 30, 45, 60 i 90 minuta nakon epiduralne primene anestetika. Poređeni su efekti epinefrina i medetomidina, ali ni jedan nije signifi kantno smanjio serumsku koncentraciju lidokaina (p>0,05). Ove kombinacije adrenergičnih agonista nisu smanjile sistemsku resorpciju lidokaina. U skladu s tim, potencijalno je moguća sistemska toksičnost lidokaina.
Кључне речи:
epidural / lidocaine / serum concentration / epinephrine / medetomidine / swineИзвор:
Acta Veterinaria-Beograd, 2014, 64, 4, 456-465Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- This study was fundend by Ministry of Science, Republic of Croatia.
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Marija, Lipar AU - Rajka, Turner AU - Berislav, Radišić AU - Lovorka, Grgurević AU - Igor, Erjavec AU - Nataša, Brajenović AU - Irena, Brčić Karačonji AU - Marko, Samardžija AU - Dražen, Vnuk PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2143 AB - Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1 : 80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these two adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential. AB - Epinefrin i alfa 2 agonisti se uvek koriste u epiduralnoj anesteziji da umanje sistemsku apsorpciju lokalnog anestetika i da produže trajanje epiduralnog bloka. U serumu svinja se određivala koncentracija lidokaina, stoga je cilj ove studije da se odredi do koje mere epinefrin i medetomidin utiču na sistemsku apsorpciju lidokaina nakon epiduralne primene. Tokom opšte anestezije prvoj grupi je epiduralno aplikovan lidokain, drugoj lidokain s epinefrinom (1: 80000), a trećoj lidokain sa medetomidinom (15 μg/ kg). Krv iz vene je uzorkovana pre, 5, 10, 20, 30, 45, 60 i 90 minuta nakon epiduralne primene anestetika. Poređeni su efekti epinefrina i medetomidina, ali ni jedan nije signifi kantno smanjio serumsku koncentraciju lidokaina (p>0,05). Ove kombinacije adrenergičnih agonista nisu smanjile sistemsku resorpciju lidokaina. U skladu s tim, potencijalno je moguća sistemska toksičnost lidokaina. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja T1 - Influence of epinephrine and medetomidine on systemic absorption of lidocaine applied epidurally in anesthetized swine VL - 64 IS - 4 SP - 456 EP - 465 DO - 10.2478/acve-2014-0043 ER -
@article{ author = "Marija, Lipar and Rajka, Turner and Berislav, Radišić and Lovorka, Grgurević and Igor, Erjavec and Nataša, Brajenović and Irena, Brčić Karačonji and Marko, Samardžija and Dražen, Vnuk", year = "2014", abstract = "Epinephrine and alpha 2 agonist drugs are often used with epidural anesthesia to minimize local anesthetic systemic absorption, as well as to prolong the duration of the block. The aim of the current study was to determine by which extent epinephrine and medetomidine influenced lidocaine systemic absorption rate following epidural application. This was achieved by monitoring the serum lidocaine concentration in a porcine model. During general anesthesia, the first group received epidurally plane lidocaine, the second received lidocaine containing epinephrine (1 : 80.000), and the third lidocaine with medetomidine (15 μg/kg). Venous blood samples were taken before and 5, 10, 20, 30, 45, 60 and 90 minutes following epidural administration of the anesthetic. The effects of epinephrine and medetomidine were comparable. They both failed to cause a significant decrease in serum lidocaine concentration (p>0.05). In these settings we were unable to demonstrate a greater capacity of these two adrenergic agonists for reducing lidocaine systemic uptake and, accordingly, its systemic toxicity potential., Epinefrin i alfa 2 agonisti se uvek koriste u epiduralnoj anesteziji da umanje sistemsku apsorpciju lokalnog anestetika i da produže trajanje epiduralnog bloka. U serumu svinja se određivala koncentracija lidokaina, stoga je cilj ove studije da se odredi do koje mere epinefrin i medetomidin utiču na sistemsku apsorpciju lidokaina nakon epiduralne primene. Tokom opšte anestezije prvoj grupi je epiduralno aplikovan lidokain, drugoj lidokain s epinefrinom (1: 80000), a trećoj lidokain sa medetomidinom (15 μg/ kg). Krv iz vene je uzorkovana pre, 5, 10, 20, 30, 45, 60 i 90 minuta nakon epiduralne primene anestetika. Poređeni su efekti epinefrina i medetomidina, ali ni jedan nije signifi kantno smanjio serumsku koncentraciju lidokaina (p>0,05). Ove kombinacije adrenergičnih agonista nisu smanjile sistemsku resorpciju lidokaina. U skladu s tim, potencijalno je moguća sistemska toksičnost lidokaina.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja, Influence of epinephrine and medetomidine on systemic absorption of lidocaine applied epidurally in anesthetized swine", volume = "64", number = "4", pages = "456-465", doi = "10.2478/acve-2014-0043" }
Marija, L., Rajka, T., Berislav, R., Lovorka, G., Igor, E., Nataša, B., Irena, B. K., Marko, S.,& Dražen, V.. (2014). Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(4), 456-465. https://doi.org/10.2478/acve-2014-0043
Marija L, Rajka T, Berislav R, Lovorka G, Igor E, Nataša B, Irena BK, Marko S, Dražen V. Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja. in Acta Veterinaria-Beograd. 2014;64(4):456-465. doi:10.2478/acve-2014-0043 .
Marija, Lipar, Rajka, Turner, Berislav, Radišić, Lovorka, Grgurević, Igor, Erjavec, Nataša, Brajenović, Irena, Brčić Karačonji, Marko, Samardžija, Dražen, Vnuk, "Uticaj epinefrina i medetomidina na sistemsku resorpciju epiduralno primenjenog lidokaina kod anesteziranih svinja" in Acta Veterinaria-Beograd, 64, no. 4 (2014):456-465, https://doi.org/10.2478/acve-2014-0043 . .