Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
Genotipske i alelske frekvencije polimorfizama u ABCG2, PPARGC1A i OLR1 genima kod domaćih rasa goveda u Turskoj
Аутори
Ateş, AtilaHoştürk, Gülhan Türkay
Akiş, Iraz
Gürsel, Feraye Esen
Yardibi, Hasret
Öztabak, Kemal
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) mtor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, onitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated recepwe might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidenc...e indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds.
Studija je obavljena u cilju određivanja polimorfi zma četiri gena kod južne anadolijske crvene (SAR) i istočne anadolijske crvene (EAR) domaće rase goveda u Turskoj. Pojedinačni nukleotidni polimorfi zmi (SNPs) koji su posmatrani u ovoj studiji su Y581S u ATP vezujućoj kaseti podfamilije G člana 2 (ABCG2) gena, c.1892T>C i c.3359A>C u PPARGC1A genu i g.8232C>A u genu za oksidisani lipoproteinski receptor male gustine (OLR1). Ustanovljeno je da je učestalost polimorfi zma alela A predaka ABCG2 gena Y581S veoma visoka (SAR: 0.63; EAR:0.64) i to kod obe rase goveda. Učestalost polimorfi zama CC genotipova PPARGC1A gena c. 1982T>C (SAR: 0.65; EAR: 0.80) i OLR1 gena g.8232C>A (SAR: 0.82; EAR: 0.86) koji su povezani sa visokim procentom masti u mleku, bile su veće u poređenju sa drugim genotipovima. U zaključku može da se sugeriše da distribucija polimorfi zma alela ABCG2 gena Y581S može da bude pokazatelj putanje autozomnog gena od zebu govečeta do SAR i EAR rasa goveda.
Кључне речи:
ABCG2 gene / East Anatolian Red / gene polymorphism / OLR1 gene / PPARGC1A gene / South Anatolian RedИзвор:
Acta Veterinaria-Beograd, 2014, 64, 1, 73-80Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- This study was supported by the Research Fund of Istanbul University, Project no: 6627.
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Ateş, Atila AU - Hoştürk, Gülhan Türkay AU - Akiş, Iraz AU - Gürsel, Feraye Esen AU - Yardibi, Hasret AU - Öztabak, Kemal PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2147 AB - This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) mtor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, onitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated recepwe might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds. AB - Studija je obavljena u cilju određivanja polimorfi zma četiri gena kod južne anadolijske crvene (SAR) i istočne anadolijske crvene (EAR) domaće rase goveda u Turskoj. Pojedinačni nukleotidni polimorfi zmi (SNPs) koji su posmatrani u ovoj studiji su Y581S u ATP vezujućoj kaseti podfamilije G člana 2 (ABCG2) gena, c.1892T>C i c.3359A>C u PPARGC1A genu i g.8232C>A u genu za oksidisani lipoproteinski receptor male gustine (OLR1). Ustanovljeno je da je učestalost polimorfi zma alela A predaka ABCG2 gena Y581S veoma visoka (SAR: 0.63; EAR:0.64) i to kod obe rase goveda. Učestalost polimorfi zama CC genotipova PPARGC1A gena c. 1982T>C (SAR: 0.65; EAR: 0.80) i OLR1 gena g.8232C>A (SAR: 0.82; EAR: 0.86) koji su povezani sa visokim procentom masti u mleku, bile su veće u poređenju sa drugim genotipovima. U zaključku može da se sugeriše da distribucija polimorfi zma alela ABCG2 gena Y581S može da bude pokazatelj putanje autozomnog gena od zebu govečeta do SAR i EAR rasa goveda. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey T1 - Genotipske i alelske frekvencije polimorfizama u ABCG2, PPARGC1A i OLR1 genima kod domaćih rasa goveda u Turskoj VL - 64 IS - 1 SP - 73 EP - 80 DO - 10.2478/acve-2014-0008 ER -
@article{ author = "Ateş, Atila and Hoştürk, Gülhan Türkay and Akiş, Iraz and Gürsel, Feraye Esen and Yardibi, Hasret and Öztabak, Kemal", year = "2014", abstract = "This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) mtor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, onitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated recepwe might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds., Studija je obavljena u cilju određivanja polimorfi zma četiri gena kod južne anadolijske crvene (SAR) i istočne anadolijske crvene (EAR) domaće rase goveda u Turskoj. Pojedinačni nukleotidni polimorfi zmi (SNPs) koji su posmatrani u ovoj studiji su Y581S u ATP vezujućoj kaseti podfamilije G člana 2 (ABCG2) gena, c.1892T>C i c.3359A>C u PPARGC1A genu i g.8232C>A u genu za oksidisani lipoproteinski receptor male gustine (OLR1). Ustanovljeno je da je učestalost polimorfi zma alela A predaka ABCG2 gena Y581S veoma visoka (SAR: 0.63; EAR:0.64) i to kod obe rase goveda. Učestalost polimorfi zama CC genotipova PPARGC1A gena c. 1982T>C (SAR: 0.65; EAR: 0.80) i OLR1 gena g.8232C>A (SAR: 0.82; EAR: 0.86) koji su povezani sa visokim procentom masti u mleku, bile su veće u poređenju sa drugim genotipovima. U zaključku može da se sugeriše da distribucija polimorfi zma alela ABCG2 gena Y581S može da bude pokazatelj putanje autozomnog gena od zebu govečeta do SAR i EAR rasa goveda.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey, Genotipske i alelske frekvencije polimorfizama u ABCG2, PPARGC1A i OLR1 genima kod domaćih rasa goveda u Turskoj", volume = "64", number = "1", pages = "73-80", doi = "10.2478/acve-2014-0008" }
Ateş, A., Hoştürk, G. T., Akiş, I., Gürsel, F. E., Yardibi, H.,& Öztabak, K.. (2014). Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(1), 73-80. https://doi.org/10.2478/acve-2014-0008
Ateş A, Hoştürk GT, Akiş I, Gürsel FE, Yardibi H, Öztabak K. Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey. in Acta Veterinaria-Beograd. 2014;64(1):73-80. doi:10.2478/acve-2014-0008 .
Ateş, Atila, Hoştürk, Gülhan Türkay, Akiş, Iraz, Gürsel, Feraye Esen, Yardibi, Hasret, Öztabak, Kemal, "Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey" in Acta Veterinaria-Beograd, 64, no. 1 (2014):73-80, https://doi.org/10.2478/acve-2014-0008 . .