Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca
Experimental assessment of a new type of vascular prostheses with adiponectin (adipograft ra 1vk 7/350) on sheep
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after ext...irpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that
Uprkos napretku medicine, razvoj idealne vaskularne proteze predstavlja značajan izazov. U ovoj studiji, obavljeno je testiranje i verifi kacija karakteristika novog tipa vaskularne prosteze upotrebom adiponektina (Adipograft Ra 1vk 7/350) koji je razvijen u Knitting istraživačkom institutu u Brnu. Dva tipa vaskularnih prosteza (12 sa adiponektinom i 6 kontrolnih, bez adiponektina) su implantirane u devet zdravih ovaca starih 4 godine, rase Merino. Implant, dužine 10 cm je implantiran u zajedničku karotidnu arteriju. Primenjena je teorija zaštićenog koaguluma pri čemu su ovce profi laktički primile antibiotsku terapiju. Pre završetka svake operacije, obavljen je Doppler U.S. u cilju verifi kacije prohodnosti prosteze. Svaka je životinja posmatrana tokom celog trajanja studije, a prosteze su uklanjane 30. i 100. dana (posle jednog i posle tri meseca). Uočeno je da su sve prosteze koje su sadržavale adiponektin posle uklanjanja pokazivale prohodnost. Celokupnom dužinom, lumen implanta je... bio veličine do 7 mm. Histološkim ispitivanjem implantiranih prosteza, ustanovljeno je brzo i veoma Podlaha and Schwanhaeuser 437 kvalitetno zarastanje. Eksperimentalni rezultati ukazuju da su vaskularne prosteze obavijene adiponektinom uspešne sa stanovišta kliničke prakse. Na osnovu rezultata prohodnosti i brzine zarastanja, može da se zaključi da Adipograft Ra 1vk 7/350 može da predstavlja revoluciju u razvoju vaskularnih prosteza.
Кључне речи:
adiponectin / experimental surgery / pre-clinical trial / vascular prosthesisИзвор:
Acta Veterinaria-Beograd, 2014, 64, 4, 426-437Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- This study was supported by the Ministry of Industry and Trade of the Czech Republic (Project: 2A - 1TP1/122).
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Jiří, Podlaha AU - Kräuff, Schwanhaeuser PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2150 AB - Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that AB - Uprkos napretku medicine, razvoj idealne vaskularne proteze predstavlja značajan izazov. U ovoj studiji, obavljeno je testiranje i verifi kacija karakteristika novog tipa vaskularne prosteze upotrebom adiponektina (Adipograft Ra 1vk 7/350) koji je razvijen u Knitting istraživačkom institutu u Brnu. Dva tipa vaskularnih prosteza (12 sa adiponektinom i 6 kontrolnih, bez adiponektina) su implantirane u devet zdravih ovaca starih 4 godine, rase Merino. Implant, dužine 10 cm je implantiran u zajedničku karotidnu arteriju. Primenjena je teorija zaštićenog koaguluma pri čemu su ovce profi laktički primile antibiotsku terapiju. Pre završetka svake operacije, obavljen je Doppler U.S. u cilju verifi kacije prohodnosti prosteze. Svaka je životinja posmatrana tokom celog trajanja studije, a prosteze su uklanjane 30. i 100. dana (posle jednog i posle tri meseca). Uočeno je da su sve prosteze koje su sadržavale adiponektin posle uklanjanja pokazivale prohodnost. Celokupnom dužinom, lumen implanta je bio veličine do 7 mm. Histološkim ispitivanjem implantiranih prosteza, ustanovljeno je brzo i veoma Podlaha and Schwanhaeuser 437 kvalitetno zarastanje. Eksperimentalni rezultati ukazuju da su vaskularne prosteze obavijene adiponektinom uspešne sa stanovišta kliničke prakse. Na osnovu rezultata prohodnosti i brzine zarastanja, može da se zaključi da Adipograft Ra 1vk 7/350 može da predstavlja revoluciju u razvoju vaskularnih prosteza. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca T1 - Experimental assessment of a new type of vascular prostheses with adiponectin (adipograft ra 1vk 7/350) on sheep VL - 64 IS - 4 SP - 426 EP - 437 DO - 10.2478/acve-2014-0040 ER -
@article{ author = "Jiří, Podlaha and Kräuff, Schwanhaeuser", year = "2014", abstract = "Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that, Uprkos napretku medicine, razvoj idealne vaskularne proteze predstavlja značajan izazov. U ovoj studiji, obavljeno je testiranje i verifi kacija karakteristika novog tipa vaskularne prosteze upotrebom adiponektina (Adipograft Ra 1vk 7/350) koji je razvijen u Knitting istraživačkom institutu u Brnu. Dva tipa vaskularnih prosteza (12 sa adiponektinom i 6 kontrolnih, bez adiponektina) su implantirane u devet zdravih ovaca starih 4 godine, rase Merino. Implant, dužine 10 cm je implantiran u zajedničku karotidnu arteriju. Primenjena je teorija zaštićenog koaguluma pri čemu su ovce profi laktički primile antibiotsku terapiju. Pre završetka svake operacije, obavljen je Doppler U.S. u cilju verifi kacije prohodnosti prosteze. Svaka je životinja posmatrana tokom celog trajanja studije, a prosteze su uklanjane 30. i 100. dana (posle jednog i posle tri meseca). Uočeno je da su sve prosteze koje su sadržavale adiponektin posle uklanjanja pokazivale prohodnost. Celokupnom dužinom, lumen implanta je bio veličine do 7 mm. Histološkim ispitivanjem implantiranih prosteza, ustanovljeno je brzo i veoma Podlaha and Schwanhaeuser 437 kvalitetno zarastanje. Eksperimentalni rezultati ukazuju da su vaskularne prosteze obavijene adiponektinom uspešne sa stanovišta kliničke prakse. Na osnovu rezultata prohodnosti i brzine zarastanja, može da se zaključi da Adipograft Ra 1vk 7/350 može da predstavlja revoluciju u razvoju vaskularnih prosteza.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca, Experimental assessment of a new type of vascular prostheses with adiponectin (adipograft ra 1vk 7/350) on sheep", volume = "64", number = "4", pages = "426-437", doi = "10.2478/acve-2014-0040" }
Jiří, P.,& Kräuff, S.. (2014). Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(4), 426-437. https://doi.org/10.2478/acve-2014-0040
Jiří P, Kräuff S. Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca. in Acta Veterinaria-Beograd. 2014;64(4):426-437. doi:10.2478/acve-2014-0040 .
Jiří, Podlaha, Kräuff, Schwanhaeuser, "Eksperimentalna procena novog tipa vaskularne proteze sa adiponektinom (adipograft ra 1vk7/350) kod ovaca" in Acta Veterinaria-Beograd, 64, no. 4 (2014):426-437, https://doi.org/10.2478/acve-2014-0040 . .