Primena pojedinih imunostimulatora u veterinarskoj medicini
Application of some immunostimulators in veterinary medicine
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U ovom revijalnom radu su izneta savremena shvatanja mehanizama delovanja,
uloga i mogućnosti primene imunostimulatornih supstanci u veterinarskoj medicini.
Imunofarmakologija je ne tako nova grana farmakologije, nastala iz sve očiglednije
potrebe da se lekovima i drugim prepratima utiče na funkcije imunskog sistema, kako
ljudi tako i životinja. U veterinarskoj medicini inunostimulatori imaju poseban značaj
zbog toga što postoji stalna potreba za zaštitom zdravlja životinja u uslovima intenzivne
proizvodnje. Jedan od najvećih problema u primeni imunomodulatornih supstanci
leži u činjenici da jedna te ista supstancija, u zavisnosti od načina i režima doziranja,
može delovati imunosupresivno ili imunostimulatorno. Ovi efekti zavise i od trenutnog
funkcionalnog stanja imunskog sistema samog pacijenta. Osim prikaza literaturnih
podataka, izneta su i sopstvena iskustva autora proizašla iz brojnih laboratorijskih
ispitivanja i ogleda na farmama. Ona se pre svega odnose na primenu ...manan-oligosaharida
u povećanju stepena resorpcije kolostralnih imunoglobulina kod teladi i prasadi,
primenu manan-oligosaharida u terapiji puerperalne disgalakcije krmača, primenu
ekstrakta goveđeg timusa kod pacova sa imunosupresijom izazvanom jonizujućim
zracima, primenu ekstrakta zida Mycobacterium phlei (Mcb. phlei) u poboljšanju
reproduktivnih rezultata krmača, primenu ekstrakta ostriga u terapiji endometritisa
krava i primenu visokih doza vitamina C u terapiji subkliničkih oblika mastitisa mlečnih
krava. Takođe je opisana i imunomodulatorna uloga antihelmintika levamizola ispitana
na modelu eksperimentalnog autoimunog encefalomijelitisa pacova kao i uticaj
ekstrakta kukureka (Helleborus odorus Waldst et Kit) na nespecifične odbrambene
mehanizme pacova.
This review article deals with the contemporary understanding of the action mechanisms,
roles and possibilities for immunostimulatory substances usage in the veterinary
medicine. Immunopharmacology is not that new branch of pharamacology,
raised from the obvious need to influence functions of the immune system both in
humans and animals by medicaments or other substances. In veterinary medicine
inunostimulants are of special significance because there is a permanent need for animal’s
health protection under conditions of intensive production. Immunostimulants
achieved a special significance since the total ban of antibiotics usage as growth stimulators
resulting in reduced health protection, especially in the intensive production.
One of the major problems regarding immunomodulators lays in the fact that the
same drug, depending on the regime and dose, may exert both immunosuppressive
and immunostimulatory effects. These effects are also dependent on the current status
of t...he immune system functions of the particular patient. In adition to the literature
data, we present our own experiences raised from the numerous laboratory
investigations and field trials. This accomplish usage of mannan-oligosacharides in
enhancing degree of absorption of colostral immunoglobulins in calves and piglets,
application of the bovine thymic extract in irradiated immunosuppressed rats, usage
of the mannan-oligosacharides in the therapy of puerperal dysgalactia in sows, usage
of Mcb. phlei call wall extract in improving reproductive results in sows, usage of the
oyster extract in the therapy of cows endometritis and application of the high vitamin
C doses in the therapy of subclinical mastites in dairy cows. Immunomodulatory effects
of anthelmintic drug, Levamisole, in the model of Experimental Autoimmune Encephalomyelitis
of rats are described as well. In addition, we have investigated effects
of Helleborus odorus (Waldst et Kit) extracts on innate defense mechanisms in rats.
Кључне речи:
antibiotici / domaće životinje / imunostimulacija / antibiotics / domestic animals / immunostimulationИзвор:
Veterinarski žurnal Republike Srpske, 2017, 17, 1, 16-36Издавач:
- Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“
Финансирање / пројекти:
- Молекуларно-генетичка и екофизиолошка истраживања у заштити аутохтоних анималних генетичких ресурса, очувању добробити, здравља и репродукције гајених животиња и производњи безбедне хране (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46002)
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Lazarević, Miodrag AU - Milovanović, Aleksandar PY - 2017 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2152 AB - U ovom revijalnom radu su izneta savremena shvatanja mehanizama delovanja, uloga i mogućnosti primene imunostimulatornih supstanci u veterinarskoj medicini. Imunofarmakologija je ne tako nova grana farmakologije, nastala iz sve očiglednije potrebe da se lekovima i drugim prepratima utiče na funkcije imunskog sistema, kako ljudi tako i životinja. U veterinarskoj medicini inunostimulatori imaju poseban značaj zbog toga što postoji stalna potreba za zaštitom zdravlja životinja u uslovima intenzivne proizvodnje. Jedan od najvećih problema u primeni imunomodulatornih supstanci leži u činjenici da jedna te ista supstancija, u zavisnosti od načina i režima doziranja, može delovati imunosupresivno ili imunostimulatorno. Ovi efekti zavise i od trenutnog funkcionalnog stanja imunskog sistema samog pacijenta. Osim prikaza literaturnih podataka, izneta su i sopstvena iskustva autora proizašla iz brojnih laboratorijskih ispitivanja i ogleda na farmama. Ona se pre svega odnose na primenu manan-oligosaharida u povećanju stepena resorpcije kolostralnih imunoglobulina kod teladi i prasadi, primenu manan-oligosaharida u terapiji puerperalne disgalakcije krmača, primenu ekstrakta goveđeg timusa kod pacova sa imunosupresijom izazvanom jonizujućim zracima, primenu ekstrakta zida Mycobacterium phlei (Mcb. phlei) u poboljšanju reproduktivnih rezultata krmača, primenu ekstrakta ostriga u terapiji endometritisa krava i primenu visokih doza vitamina C u terapiji subkliničkih oblika mastitisa mlečnih krava. Takođe je opisana i imunomodulatorna uloga antihelmintika levamizola ispitana na modelu eksperimentalnog autoimunog encefalomijelitisa pacova kao i uticaj ekstrakta kukureka (Helleborus odorus Waldst et Kit) na nespecifične odbrambene mehanizme pacova. AB - This review article deals with the contemporary understanding of the action mechanisms, roles and possibilities for immunostimulatory substances usage in the veterinary medicine. Immunopharmacology is not that new branch of pharamacology, raised from the obvious need to influence functions of the immune system both in humans and animals by medicaments or other substances. In veterinary medicine inunostimulants are of special significance because there is a permanent need for animal’s health protection under conditions of intensive production. Immunostimulants achieved a special significance since the total ban of antibiotics usage as growth stimulators resulting in reduced health protection, especially in the intensive production. One of the major problems regarding immunomodulators lays in the fact that the same drug, depending on the regime and dose, may exert both immunosuppressive and immunostimulatory effects. These effects are also dependent on the current status of the immune system functions of the particular patient. In adition to the literature data, we present our own experiences raised from the numerous laboratory investigations and field trials. This accomplish usage of mannan-oligosacharides in enhancing degree of absorption of colostral immunoglobulins in calves and piglets, application of the bovine thymic extract in irradiated immunosuppressed rats, usage of the mannan-oligosacharides in the therapy of puerperal dysgalactia in sows, usage of Mcb. phlei call wall extract in improving reproductive results in sows, usage of the oyster extract in the therapy of cows endometritis and application of the high vitamin C doses in the therapy of subclinical mastites in dairy cows. Immunomodulatory effects of anthelmintic drug, Levamisole, in the model of Experimental Autoimmune Encephalomyelitis of rats are described as well. In addition, we have investigated effects of Helleborus odorus (Waldst et Kit) extracts on innate defense mechanisms in rats. PB - Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“ T2 - Veterinarski žurnal Republike Srpske T1 - Primena pojedinih imunostimulatora u veterinarskoj medicini T1 - Application of some immunostimulators in veterinary medicine VL - 17 IS - 1 SP - 16 EP - 36 DO - 10.7251/VETJ1701016L ER -
@article{ author = "Lazarević, Miodrag and Milovanović, Aleksandar", year = "2017", abstract = "U ovom revijalnom radu su izneta savremena shvatanja mehanizama delovanja, uloga i mogućnosti primene imunostimulatornih supstanci u veterinarskoj medicini. Imunofarmakologija je ne tako nova grana farmakologije, nastala iz sve očiglednije potrebe da se lekovima i drugim prepratima utiče na funkcije imunskog sistema, kako ljudi tako i životinja. U veterinarskoj medicini inunostimulatori imaju poseban značaj zbog toga što postoji stalna potreba za zaštitom zdravlja životinja u uslovima intenzivne proizvodnje. Jedan od najvećih problema u primeni imunomodulatornih supstanci leži u činjenici da jedna te ista supstancija, u zavisnosti od načina i režima doziranja, može delovati imunosupresivno ili imunostimulatorno. Ovi efekti zavise i od trenutnog funkcionalnog stanja imunskog sistema samog pacijenta. Osim prikaza literaturnih podataka, izneta su i sopstvena iskustva autora proizašla iz brojnih laboratorijskih ispitivanja i ogleda na farmama. Ona se pre svega odnose na primenu manan-oligosaharida u povećanju stepena resorpcije kolostralnih imunoglobulina kod teladi i prasadi, primenu manan-oligosaharida u terapiji puerperalne disgalakcije krmača, primenu ekstrakta goveđeg timusa kod pacova sa imunosupresijom izazvanom jonizujućim zracima, primenu ekstrakta zida Mycobacterium phlei (Mcb. phlei) u poboljšanju reproduktivnih rezultata krmača, primenu ekstrakta ostriga u terapiji endometritisa krava i primenu visokih doza vitamina C u terapiji subkliničkih oblika mastitisa mlečnih krava. Takođe je opisana i imunomodulatorna uloga antihelmintika levamizola ispitana na modelu eksperimentalnog autoimunog encefalomijelitisa pacova kao i uticaj ekstrakta kukureka (Helleborus odorus Waldst et Kit) na nespecifične odbrambene mehanizme pacova., This review article deals with the contemporary understanding of the action mechanisms, roles and possibilities for immunostimulatory substances usage in the veterinary medicine. Immunopharmacology is not that new branch of pharamacology, raised from the obvious need to influence functions of the immune system both in humans and animals by medicaments or other substances. In veterinary medicine inunostimulants are of special significance because there is a permanent need for animal’s health protection under conditions of intensive production. Immunostimulants achieved a special significance since the total ban of antibiotics usage as growth stimulators resulting in reduced health protection, especially in the intensive production. One of the major problems regarding immunomodulators lays in the fact that the same drug, depending on the regime and dose, may exert both immunosuppressive and immunostimulatory effects. These effects are also dependent on the current status of the immune system functions of the particular patient. In adition to the literature data, we present our own experiences raised from the numerous laboratory investigations and field trials. This accomplish usage of mannan-oligosacharides in enhancing degree of absorption of colostral immunoglobulins in calves and piglets, application of the bovine thymic extract in irradiated immunosuppressed rats, usage of the mannan-oligosacharides in the therapy of puerperal dysgalactia in sows, usage of Mcb. phlei call wall extract in improving reproductive results in sows, usage of the oyster extract in the therapy of cows endometritis and application of the high vitamin C doses in the therapy of subclinical mastites in dairy cows. Immunomodulatory effects of anthelmintic drug, Levamisole, in the model of Experimental Autoimmune Encephalomyelitis of rats are described as well. In addition, we have investigated effects of Helleborus odorus (Waldst et Kit) extracts on innate defense mechanisms in rats.", publisher = "Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“", journal = "Veterinarski žurnal Republike Srpske", title = "Primena pojedinih imunostimulatora u veterinarskoj medicini, Application of some immunostimulators in veterinary medicine", volume = "17", number = "1", pages = "16-36", doi = "10.7251/VETJ1701016L" }
Lazarević, M.,& Milovanović, A.. (2017). Primena pojedinih imunostimulatora u veterinarskoj medicini. in Veterinarski žurnal Republike Srpske Banja Luka : PI Veterinary Institute Republic of Srpska „Dr. Vaso Butozan“., 17(1), 16-36. https://doi.org/10.7251/VETJ1701016L
Lazarević M, Milovanović A. Primena pojedinih imunostimulatora u veterinarskoj medicini. in Veterinarski žurnal Republike Srpske. 2017;17(1):16-36. doi:10.7251/VETJ1701016L .
Lazarević, Miodrag, Milovanović, Aleksandar, "Primena pojedinih imunostimulatora u veterinarskoj medicini" in Veterinarski žurnal Republike Srpske, 17, no. 1 (2017):16-36, https://doi.org/10.7251/VETJ1701016L . .