Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery
Kardiorespiratorni i hemodinamički efekti medetomidina ili ksilazina sa atropin i diazepam premedikacijom prilikom indukovanja totalne intravenske anestezije sa propofol/fentanil-om kod pasa tokom hirurških intervencija
Аутори
Tomáš, LiptákIgor, Capík
Valent, Ledecký
Oskar, Nagy
Mária, Kuricová
Csilla, Tóthová
Aladár, Maďari
Jana, Farbáková
Vladimír, Petrovič
Slavomír, Horňák
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine and diazepam). Cardiorespiratory variables, acid-base indices, quality of sedation, induction, intubation and recovery were recorded throughout the experiment. Signifi cant changes were observed for the pO2 level, which was increased in the AMDgroup from 90 min. (*P< 0.05) to 120 min. (**P< 0.01) of anesthesia. This can be explained by a reduction of the administration rate of propofol/fentanyl TIVA and oxygenation initiated due to excessively deep anesthesia detected by an anesthetsiologist, leading to improved ventilation and increased pO2 . The pCO2 (*P < 0.05) reached more preferable values during the fi rst 30 min. and pH (**P< 0.01) was signifi cantly improved within the fi rst 60 mi...n. in the AXD-group thanks to less depressant effects of xylazine. Within the fi rst 30 min. of anesthesia a signifi cant heart rate difference between the groups was accompanied with signifi cantly higher BP (hypertension) in the AXD-group (10 min. ***P< 0.001, 30 min. **P< 0.01). This points to the possibility of atropine application only in the case of a tendency to bradycardia followed by hypotension. It can be concluded that xylazine is a better option for the premedication of a propofol/ fentanyl TIVA in dogs undergoing a prolonged surgical intervention, in spite of the fact that lower sedation scores were attained. We have detected signifi cantly less adverse cardio-respiratory and hemodynamic effects of xylazine, and a shorter recovery time when compared to medetomidine.
Obavljeno je upoređivanje efekata različitih protokola premedikacije koji su prethodili propofol/fentanil TIVA na kardio-respiratorne i hemodinamičke promene kod 24 psa koji su podeljeni u dve grupe (AMD-grupa: medetomidin, atropin i diazepam; AXD-grupa: xylazin, atropin i diazepam). Tokom ogleda, praćene su promenljive kardio-respiratorne vrednosti, acido-bazne vrednosti, kvalitet sedacije, indukcija sedacije, intubacija i stepen oporavka od anestezije. Značajne promene su uočene u odnosu na pO2 koje su bile povećane u AMD-grupi od 90 (*P<0.05) do 120 minuta (**P<0.01) anestezije. Ovo može da se objasni smanjenjem brzine davanja propofol/fentanil TIVA i oksigenacijom koja je izazvana naročito dubokom anestezijom koja je uočena od strane anesteziologa, što je vodilo pojačanoj ventilaciji i povećanim vrednostima pO2. Zahvaljujući slabijim depresivnim efektima ksilazina, u AXD grupi, nivoi pCO2 (*P<0.05) su dostizali željene vrednosti tokom prvih 30 minuta, a pH (**P<0.01) vrednosti su b...ile značajno poboljšane u prvih 60 minuta. U prvih 30 minuta anestezije, uočene su značajne razlike u radu srca (puls) između grupa pri čemu su vrednosti BP (hipertenzija) bile značajno veće u AXD grupi (10 min. ***P<0.001, 30 min. **P<0.01). Ovo ukazuje na mogućnost aplikacije atropina samo u slučaju postojanja tendencije razvoja bradikardije koja bi prethodila hipotenziji. Na osnovu rezultata može da se zaključi da je ksilazin bolja opcija za premedikaciju tokom propofol/fentanil TIVA anestezije kod pasa tokom produžene hirurške intervencije, uprkos činjenici da su ustanovljeni niži skorovi sedacije. Ustanovljeni su manje značajni neželjeni kardio-respiratorni i hemodinamički efekti ksilazina, kao i kraće vreme buđenja u poređenju sa medetomidinom.
Кључне речи:
intravenous anesthesia / long-term anesthesia / dog / Fentanyl / PropofolИзвор:
Acta Veterinaria-Beograd, 2014, 64, 4, 466-476Финансирање / пројекти:
- This research was supported by VEGA grant no. 1/0212/12 from the Ministry of Education, Science, Research and Sport of the Slovak Republic.
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Tomáš, Lipták AU - Igor, Capík AU - Valent, Ledecký AU - Oskar, Nagy AU - Mária, Kuricová AU - Csilla, Tóthová AU - Aladár, Maďari AU - Jana, Farbáková AU - Vladimír, Petrovič AU - Slavomír, Horňák PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2184 AB - The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine and diazepam). Cardiorespiratory variables, acid-base indices, quality of sedation, induction, intubation and recovery were recorded throughout the experiment. Signifi cant changes were observed for the pO2 level, which was increased in the AMDgroup from 90 min. (*P< 0.05) to 120 min. (**P< 0.01) of anesthesia. This can be explained by a reduction of the administration rate of propofol/fentanyl TIVA and oxygenation initiated due to excessively deep anesthesia detected by an anesthetsiologist, leading to improved ventilation and increased pO2 . The pCO2 (*P < 0.05) reached more preferable values during the fi rst 30 min. and pH (**P< 0.01) was signifi cantly improved within the fi rst 60 min. in the AXD-group thanks to less depressant effects of xylazine. Within the fi rst 30 min. of anesthesia a signifi cant heart rate difference between the groups was accompanied with signifi cantly higher BP (hypertension) in the AXD-group (10 min. ***P< 0.001, 30 min. **P< 0.01). This points to the possibility of atropine application only in the case of a tendency to bradycardia followed by hypotension. It can be concluded that xylazine is a better option for the premedication of a propofol/ fentanyl TIVA in dogs undergoing a prolonged surgical intervention, in spite of the fact that lower sedation scores were attained. We have detected signifi cantly less adverse cardio-respiratory and hemodynamic effects of xylazine, and a shorter recovery time when compared to medetomidine. AB - Obavljeno je upoređivanje efekata različitih protokola premedikacije koji su prethodili propofol/fentanil TIVA na kardio-respiratorne i hemodinamičke promene kod 24 psa koji su podeljeni u dve grupe (AMD-grupa: medetomidin, atropin i diazepam; AXD-grupa: xylazin, atropin i diazepam). Tokom ogleda, praćene su promenljive kardio-respiratorne vrednosti, acido-bazne vrednosti, kvalitet sedacije, indukcija sedacije, intubacija i stepen oporavka od anestezije. Značajne promene su uočene u odnosu na pO2 koje su bile povećane u AMD-grupi od 90 (*P<0.05) do 120 minuta (**P<0.01) anestezije. Ovo može da se objasni smanjenjem brzine davanja propofol/fentanil TIVA i oksigenacijom koja je izazvana naročito dubokom anestezijom koja je uočena od strane anesteziologa, što je vodilo pojačanoj ventilaciji i povećanim vrednostima pO2. Zahvaljujući slabijim depresivnim efektima ksilazina, u AXD grupi, nivoi pCO2 (*P<0.05) su dostizali željene vrednosti tokom prvih 30 minuta, a pH (**P<0.01) vrednosti su bile značajno poboljšane u prvih 60 minuta. U prvih 30 minuta anestezije, uočene su značajne razlike u radu srca (puls) između grupa pri čemu su vrednosti BP (hipertenzija) bile značajno veće u AXD grupi (10 min. ***P<0.001, 30 min. **P<0.01). Ovo ukazuje na mogućnost aplikacije atropina samo u slučaju postojanja tendencije razvoja bradikardije koja bi prethodila hipotenziji. Na osnovu rezultata može da se zaključi da je ksilazin bolja opcija za premedikaciju tokom propofol/fentanil TIVA anestezije kod pasa tokom produžene hirurške intervencije, uprkos činjenici da su ustanovljeni niži skorovi sedacije. Ustanovljeni su manje značajni neželjeni kardio-respiratorni i hemodinamički efekti ksilazina, kao i kraće vreme buđenja u poređenju sa medetomidinom. T2 - Acta Veterinaria-Beograd T1 - Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery T1 - Kardiorespiratorni i hemodinamički efekti medetomidina ili ksilazina sa atropin i diazepam premedikacijom prilikom indukovanja totalne intravenske anestezije sa propofol/fentanil-om kod pasa tokom hirurških intervencija VL - 64 IS - 4 SP - 466 EP - 476 DO - 10.2478/acve-2014-0044 ER -
@article{ author = "Tomáš, Lipták and Igor, Capík and Valent, Ledecký and Oskar, Nagy and Mária, Kuricová and Csilla, Tóthová and Aladár, Maďari and Jana, Farbáková and Vladimír, Petrovič and Slavomír, Horňák", year = "2014", abstract = "The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine and diazepam). Cardiorespiratory variables, acid-base indices, quality of sedation, induction, intubation and recovery were recorded throughout the experiment. Signifi cant changes were observed for the pO2 level, which was increased in the AMDgroup from 90 min. (*P< 0.05) to 120 min. (**P< 0.01) of anesthesia. This can be explained by a reduction of the administration rate of propofol/fentanyl TIVA and oxygenation initiated due to excessively deep anesthesia detected by an anesthetsiologist, leading to improved ventilation and increased pO2 . The pCO2 (*P < 0.05) reached more preferable values during the fi rst 30 min. and pH (**P< 0.01) was signifi cantly improved within the fi rst 60 min. in the AXD-group thanks to less depressant effects of xylazine. Within the fi rst 30 min. of anesthesia a signifi cant heart rate difference between the groups was accompanied with signifi cantly higher BP (hypertension) in the AXD-group (10 min. ***P< 0.001, 30 min. **P< 0.01). This points to the possibility of atropine application only in the case of a tendency to bradycardia followed by hypotension. It can be concluded that xylazine is a better option for the premedication of a propofol/ fentanyl TIVA in dogs undergoing a prolonged surgical intervention, in spite of the fact that lower sedation scores were attained. We have detected signifi cantly less adverse cardio-respiratory and hemodynamic effects of xylazine, and a shorter recovery time when compared to medetomidine., Obavljeno je upoređivanje efekata različitih protokola premedikacije koji su prethodili propofol/fentanil TIVA na kardio-respiratorne i hemodinamičke promene kod 24 psa koji su podeljeni u dve grupe (AMD-grupa: medetomidin, atropin i diazepam; AXD-grupa: xylazin, atropin i diazepam). Tokom ogleda, praćene su promenljive kardio-respiratorne vrednosti, acido-bazne vrednosti, kvalitet sedacije, indukcija sedacije, intubacija i stepen oporavka od anestezije. Značajne promene su uočene u odnosu na pO2 koje su bile povećane u AMD-grupi od 90 (*P<0.05) do 120 minuta (**P<0.01) anestezije. Ovo može da se objasni smanjenjem brzine davanja propofol/fentanil TIVA i oksigenacijom koja je izazvana naročito dubokom anestezijom koja je uočena od strane anesteziologa, što je vodilo pojačanoj ventilaciji i povećanim vrednostima pO2. Zahvaljujući slabijim depresivnim efektima ksilazina, u AXD grupi, nivoi pCO2 (*P<0.05) su dostizali željene vrednosti tokom prvih 30 minuta, a pH (**P<0.01) vrednosti su bile značajno poboljšane u prvih 60 minuta. U prvih 30 minuta anestezije, uočene su značajne razlike u radu srca (puls) između grupa pri čemu su vrednosti BP (hipertenzija) bile značajno veće u AXD grupi (10 min. ***P<0.001, 30 min. **P<0.01). Ovo ukazuje na mogućnost aplikacije atropina samo u slučaju postojanja tendencije razvoja bradikardije koja bi prethodila hipotenziji. Na osnovu rezultata može da se zaključi da je ksilazin bolja opcija za premedikaciju tokom propofol/fentanil TIVA anestezije kod pasa tokom produžene hirurške intervencije, uprkos činjenici da su ustanovljeni niži skorovi sedacije. Ustanovljeni su manje značajni neželjeni kardio-respiratorni i hemodinamički efekti ksilazina, kao i kraće vreme buđenja u poređenju sa medetomidinom.", journal = "Acta Veterinaria-Beograd", title = "Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery, Kardiorespiratorni i hemodinamički efekti medetomidina ili ksilazina sa atropin i diazepam premedikacijom prilikom indukovanja totalne intravenske anestezije sa propofol/fentanil-om kod pasa tokom hirurških intervencija", volume = "64", number = "4", pages = "466-476", doi = "10.2478/acve-2014-0044" }
Tomáš, L., Igor, C., Valent, L., Oskar, N., Mária, K., Csilla, T., Aladár, M., Jana, F., Vladimír, P.,& Slavomír, H.. (2014). Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery. in Acta Veterinaria-Beograd, 64(4), 466-476. https://doi.org/10.2478/acve-2014-0044
Tomáš L, Igor C, Valent L, Oskar N, Mária K, Csilla T, Aladár M, Jana F, Vladimír P, Slavomír H. Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery. in Acta Veterinaria-Beograd. 2014;64(4):466-476. doi:10.2478/acve-2014-0044 .
Tomáš, Lipták, Igor, Capík, Valent, Ledecký, Oskar, Nagy, Mária, Kuricová, Csilla, Tóthová, Aladár, Maďari, Jana, Farbáková, Vladimír, Petrovič, Slavomír, Horňák, "Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery" in Acta Veterinaria-Beograd, 64, no. 4 (2014):466-476, https://doi.org/10.2478/acve-2014-0044 . .