A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
Vakcinacija sa jednom dozom elastaza-zavisnog živog atenuiranong H1N1 virusa influence svinja obezbeđuje dovoljnu zaštitu protiv 2009 pandemičnog H1N1 virusa kod svinja
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The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the ...absence of neutralizing antibodies specific for H1N1 2009 in sera.
Pandemija izazvana virusom influence A tipa H1N1 u 2009. godini, istakla je značaj svinja u evoluciji virusa infl uence A i pojavu novih virusa sa pandemijskim potencijalom. Takođe, infekcije virusom infl uence A značajno doprinose smanjenju proizvodnje u poljoprivrednoj industriji što za rezultat ima povećanje gubitaka i značajan pad profi ta. Primarni metod za kontrolu virusnih infekcija izazvanih virusom infl uence A kod svinja je putem vakcinacije. Prethodno smo demonstrirali da dve doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja date intratrahealno ili intranazalno mogu da obezbede visok stepen zaštite svinja od novih infekcija sa homolognim i različitim heterologim virusima infl uence svinja. U ovom radu smo opisali efi kasnost vakcinacije jedne doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja, date intranazalno, protiv infekcije sa homolognim 2009 pandemičnim virusom subtipa H1N1. Zaštita protiv H1N1 2009 virusa kod vakcinisanih svinja je pri...mećena i u odsustvu neutralizacionih antitela u serumu specifičnih za H1N1 2009 virus.
Кључне речи:
H1N1 / swine influenza / pandemic influenza / vaccineИзвор:
Acta Veterinaria-Beograd, 2014, 64, 1, 10-23
DOI: 10.2478/acve-2014-0002
ISBN: 0567-8315
ISSN: 0567-8315
Scopus: 2-s2.0-84902516939
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Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Mašić, Aleksandar AU - Woldeab, Niziti AU - Embury-Hyatt, Carissa AU - Zhou, Yan AU - Babiuk, Shawn PY - 2014 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2189 AB - The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the absence of neutralizing antibodies specific for H1N1 2009 in sera. AB - Pandemija izazvana virusom influence A tipa H1N1 u 2009. godini, istakla je značaj svinja u evoluciji virusa infl uence A i pojavu novih virusa sa pandemijskim potencijalom. Takođe, infekcije virusom infl uence A značajno doprinose smanjenju proizvodnje u poljoprivrednoj industriji što za rezultat ima povećanje gubitaka i značajan pad profi ta. Primarni metod za kontrolu virusnih infekcija izazvanih virusom infl uence A kod svinja je putem vakcinacije. Prethodno smo demonstrirali da dve doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja date intratrahealno ili intranazalno mogu da obezbede visok stepen zaštite svinja od novih infekcija sa homolognim i različitim heterologim virusima infl uence svinja. U ovom radu smo opisali efi kasnost vakcinacije jedne doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja, date intranazalno, protiv infekcije sa homolognim 2009 pandemičnim virusom subtipa H1N1. Zaštita protiv H1N1 2009 virusa kod vakcinisanih svinja je primećena i u odsustvu neutralizacionih antitela u serumu specifičnih za H1N1 2009 virus. T2 - Acta Veterinaria-Beograd T1 - A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus T1 - Vakcinacija sa jednom dozom elastaza-zavisnog živog atenuiranong H1N1 virusa influence svinja obezbeđuje dovoljnu zaštitu protiv 2009 pandemičnog H1N1 virusa kod svinja VL - 64 IS - 1 SP - 10 EP - 23 DO - 10.2478/acve-2014-0002 ER -
@article{ author = "Mašić, Aleksandar and Woldeab, Niziti and Embury-Hyatt, Carissa and Zhou, Yan and Babiuk, Shawn", year = "2014", abstract = "The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the absence of neutralizing antibodies specific for H1N1 2009 in sera., Pandemija izazvana virusom influence A tipa H1N1 u 2009. godini, istakla je značaj svinja u evoluciji virusa infl uence A i pojavu novih virusa sa pandemijskim potencijalom. Takođe, infekcije virusom infl uence A značajno doprinose smanjenju proizvodnje u poljoprivrednoj industriji što za rezultat ima povećanje gubitaka i značajan pad profi ta. Primarni metod za kontrolu virusnih infekcija izazvanih virusom infl uence A kod svinja je putem vakcinacije. Prethodno smo demonstrirali da dve doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja date intratrahealno ili intranazalno mogu da obezbede visok stepen zaštite svinja od novih infekcija sa homolognim i različitim heterologim virusima infl uence svinja. U ovom radu smo opisali efi kasnost vakcinacije jedne doze elastaza-zavisnog, živog atenuiranog virusa infl uence svinja, date intranazalno, protiv infekcije sa homolognim 2009 pandemičnim virusom subtipa H1N1. Zaštita protiv H1N1 2009 virusa kod vakcinisanih svinja je primećena i u odsustvu neutralizacionih antitela u serumu specifičnih za H1N1 2009 virus.", journal = "Acta Veterinaria-Beograd", title = "A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus, Vakcinacija sa jednom dozom elastaza-zavisnog živog atenuiranong H1N1 virusa influence svinja obezbeđuje dovoljnu zaštitu protiv 2009 pandemičnog H1N1 virusa kod svinja", volume = "64", number = "1", pages = "10-23", doi = "10.2478/acve-2014-0002" }
Mašić, A., Woldeab, N., Embury-Hyatt, C., Zhou, Y.,& Babiuk, S.. (2014). A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus. in Acta Veterinaria-Beograd, 64(1), 10-23. https://doi.org/10.2478/acve-2014-0002
Mašić A, Woldeab N, Embury-Hyatt C, Zhou Y, Babiuk S. A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus. in Acta Veterinaria-Beograd. 2014;64(1):10-23. doi:10.2478/acve-2014-0002 .
Mašić, Aleksandar, Woldeab, Niziti, Embury-Hyatt, Carissa, Zhou, Yan, Babiuk, Shawn, "A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus" in Acta Veterinaria-Beograd, 64, no. 1 (2014):10-23, https://doi.org/10.2478/acve-2014-0002 . .