The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible
Uticaj eksperimentalno zračene hipofize na rast potkolenice, lobanje, gornje i donje vilice pacova
Апстракт
Background/Aim. The reaction of an organism to radiation depends on the level of irradiation and the sensitivity of the affected tissue cells. The biological effects on the cells and tissues are proportional to the absorbed radiation energy. The aim of our study was to examine the effects of hypofunction of the pituitary gland, previously irradiated with x-rays, on the growth of rat’s craniofacial and stomatognathic system as well as rat’s tibia. Methods. A total dose of x-rays of 27.92 Gy was applied in eight sessions in the period from 8 to 63 days of animal age on their heads and the effects of irradiation-induced hypofunction of the pituitary gland on the growth of rat’s craniofacial and stomatognathic system and tibia were examined. In order to differentiate the effects of the irradiated pituitary gland from the direct effects of x-rays on the head, the experiment was set as a double study. One group of animals had the pituitary gland protected with a lead plate set beneath the pr...ojection of the gland, while the second group was irradiated with the same dose, but without the protection. The control group of animals were non-irradiated. Results. Growth measurements of numerous parameters of the craniofacial and stomatognathic system as well as tibia in rats with the entire locally irradiated head showed a statistically significant delay, compared to both the non-irradiated control group and the group with the protected pituitary gland. Conclusion. The damage of the stomatognathic and craniofacial system was greater in animals with irradiated head without pituitary gland protection compared to those with the gland protection whereby the growth of the craniofacial system was most affected. Irraduition-induced pituitary gland hypofunction and irradiation itself showed a stronger effect on the lower jaw growth rate impairment compared to the upper jaw. Similarly, the delay in tibia growth was more pronounced in animals without pituitary gland protection during irradiation of their heads compared to non-protected ones.
Uvod/Cilj. Reakcija organizma na zračenje zavisi od doze
zračenja i osetljivosti ćelija tretiranog tkiva. Biološki efekti
zračenja na ćelije i tkiva proporcionalni su apsorbovanoj radijacionoj energiji. Cilj istraživanja je bio da se ispitaju efekti
hipofunkcije prethodno x-zracima ozračene hipofize na rast
kraniofacijalnog i stomatognatnog sistema pacova. Metode.
Primenjena doza x-zračenja od 27,92 Gy aplicirana je na
dve grupe pacova u 8 seansi tokom perioda od 8 do 63 dana
njihove starosti, uz praćenje efekata zračenja na rast kraniofacijalnog i stomatognatog sistema. U nameri da u merenju
brojnih parametara pomenutih sistema razdvojimo efekte ozračene hipofize od direktnih efekata x zraka koje smo primenili na glavu, postavljen je eksperiment sa ozračivanjem glave
dvema grupama životinja istim dozama x zraka, ali je jednoj zaštićena hipofiza olovnom pločicom postavljenom iznad
hipofiza. Rezultati. Zaostajanje u rastu stomatognatog sistema kod pacova kojima je lokalno ozra...čena cela glava u odnosu na kontrolne životinje predstavlja zbirni efekat delovanja zračenjem izazvane hipofunkcije hipofize i direktnog delovanja x zračenja, dok zaostajanje u rastu stomatognatog
sistema kod pacova sa ozračenom glavom i hipofizom
zaštićenom od zračenja predstavlja isključivo efekat x zraka.
Zaključak. Oštećenja stomatognatog i kraniofacijalnog
sistema bila su veća kod životinja kojima hipofiza tokom
zračenja glave nije bila zaštićena u odnosu na one sa zaštitom
žlezde prilikom zračenja, pri čemu je rast kraniofacijalnog
sistema u sagitalnom pravcu bio najviše pogođen. Veći zaostatak u rastu usled kombinovanoig dejstva hipofunkcije
hipofize izazvane zračenjem i samog zračanje ustanovljen je
na donjoj vilici u odnosu na gornju vilicu. Slično ovome, zao stajanje u rastu tibije bilo je izraženije kod životinja kojima
tokom zračenja cele glave hipofiza nije bila zaštićena u odnosu na neštićene životinje.
Кључне речи:
Growth / Maxilla, mandible / Pituitary gland / Rats / Skull / Tibia / X-rays / hipofiza / x zraci / pacovi / rast / tibija / lobanja / gornja vilica / donja vilicaИзвор:
Vojnosanitetski pregled, 2021, 78, 9, 964-972Издавач:
- Savezno Ministarstvo Odbrane, Beograd
DOI: 10.2298/VSP190904005M
ISSN: 0042-8450
WoS: 000707506000010
Scopus: 2-s2.0-85118503087
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Milosavljević, Željko AU - Krstić, Nikola PY - 2021 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/2248 AB - Background/Aim. The reaction of an organism to radiation depends on the level of irradiation and the sensitivity of the affected tissue cells. The biological effects on the cells and tissues are proportional to the absorbed radiation energy. The aim of our study was to examine the effects of hypofunction of the pituitary gland, previously irradiated with x-rays, on the growth of rat’s craniofacial and stomatognathic system as well as rat’s tibia. Methods. A total dose of x-rays of 27.92 Gy was applied in eight sessions in the period from 8 to 63 days of animal age on their heads and the effects of irradiation-induced hypofunction of the pituitary gland on the growth of rat’s craniofacial and stomatognathic system and tibia were examined. In order to differentiate the effects of the irradiated pituitary gland from the direct effects of x-rays on the head, the experiment was set as a double study. One group of animals had the pituitary gland protected with a lead plate set beneath the projection of the gland, while the second group was irradiated with the same dose, but without the protection. The control group of animals were non-irradiated. Results. Growth measurements of numerous parameters of the craniofacial and stomatognathic system as well as tibia in rats with the entire locally irradiated head showed a statistically significant delay, compared to both the non-irradiated control group and the group with the protected pituitary gland. Conclusion. The damage of the stomatognathic and craniofacial system was greater in animals with irradiated head without pituitary gland protection compared to those with the gland protection whereby the growth of the craniofacial system was most affected. Irraduition-induced pituitary gland hypofunction and irradiation itself showed a stronger effect on the lower jaw growth rate impairment compared to the upper jaw. Similarly, the delay in tibia growth was more pronounced in animals without pituitary gland protection during irradiation of their heads compared to non-protected ones. AB - Uvod/Cilj. Reakcija organizma na zračenje zavisi od doze zračenja i osetljivosti ćelija tretiranog tkiva. Biološki efekti zračenja na ćelije i tkiva proporcionalni su apsorbovanoj radijacionoj energiji. Cilj istraživanja je bio da se ispitaju efekti hipofunkcije prethodno x-zracima ozračene hipofize na rast kraniofacijalnog i stomatognatnog sistema pacova. Metode. Primenjena doza x-zračenja od 27,92 Gy aplicirana je na dve grupe pacova u 8 seansi tokom perioda od 8 do 63 dana njihove starosti, uz praćenje efekata zračenja na rast kraniofacijalnog i stomatognatog sistema. U nameri da u merenju brojnih parametara pomenutih sistema razdvojimo efekte ozračene hipofize od direktnih efekata x zraka koje smo primenili na glavu, postavljen je eksperiment sa ozračivanjem glave dvema grupama životinja istim dozama x zraka, ali je jednoj zaštićena hipofiza olovnom pločicom postavljenom iznad hipofiza. Rezultati. Zaostajanje u rastu stomatognatog sistema kod pacova kojima je lokalno ozračena cela glava u odnosu na kontrolne životinje predstavlja zbirni efekat delovanja zračenjem izazvane hipofunkcije hipofize i direktnog delovanja x zračenja, dok zaostajanje u rastu stomatognatog sistema kod pacova sa ozračenom glavom i hipofizom zaštićenom od zračenja predstavlja isključivo efekat x zraka. Zaključak. Oštećenja stomatognatog i kraniofacijalnog sistema bila su veća kod životinja kojima hipofiza tokom zračenja glave nije bila zaštićena u odnosu na one sa zaštitom žlezde prilikom zračenja, pri čemu je rast kraniofacijalnog sistema u sagitalnom pravcu bio najviše pogođen. Veći zaostatak u rastu usled kombinovanoig dejstva hipofunkcije hipofize izazvane zračenjem i samog zračanje ustanovljen je na donjoj vilici u odnosu na gornju vilicu. Slično ovome, zao stajanje u rastu tibije bilo je izraženije kod životinja kojima tokom zračenja cele glave hipofiza nije bila zaštićena u odnosu na neštićene životinje. PB - Savezno Ministarstvo Odbrane, Beograd T2 - Vojnosanitetski pregled T1 - The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible T1 - Uticaj eksperimentalno zračene hipofize na rast potkolenice, lobanje, gornje i donje vilice pacova VL - 78 IS - 9 SP - 964 EP - 972 DO - 10.2298/VSP190904005M ER -
@article{ author = "Milosavljević, Željko and Krstić, Nikola", year = "2021", abstract = "Background/Aim. The reaction of an organism to radiation depends on the level of irradiation and the sensitivity of the affected tissue cells. The biological effects on the cells and tissues are proportional to the absorbed radiation energy. The aim of our study was to examine the effects of hypofunction of the pituitary gland, previously irradiated with x-rays, on the growth of rat’s craniofacial and stomatognathic system as well as rat’s tibia. Methods. A total dose of x-rays of 27.92 Gy was applied in eight sessions in the period from 8 to 63 days of animal age on their heads and the effects of irradiation-induced hypofunction of the pituitary gland on the growth of rat’s craniofacial and stomatognathic system and tibia were examined. In order to differentiate the effects of the irradiated pituitary gland from the direct effects of x-rays on the head, the experiment was set as a double study. One group of animals had the pituitary gland protected with a lead plate set beneath the projection of the gland, while the second group was irradiated with the same dose, but without the protection. The control group of animals were non-irradiated. Results. Growth measurements of numerous parameters of the craniofacial and stomatognathic system as well as tibia in rats with the entire locally irradiated head showed a statistically significant delay, compared to both the non-irradiated control group and the group with the protected pituitary gland. Conclusion. The damage of the stomatognathic and craniofacial system was greater in animals with irradiated head without pituitary gland protection compared to those with the gland protection whereby the growth of the craniofacial system was most affected. Irraduition-induced pituitary gland hypofunction and irradiation itself showed a stronger effect on the lower jaw growth rate impairment compared to the upper jaw. Similarly, the delay in tibia growth was more pronounced in animals without pituitary gland protection during irradiation of their heads compared to non-protected ones., Uvod/Cilj. Reakcija organizma na zračenje zavisi od doze zračenja i osetljivosti ćelija tretiranog tkiva. Biološki efekti zračenja na ćelije i tkiva proporcionalni su apsorbovanoj radijacionoj energiji. Cilj istraživanja je bio da se ispitaju efekti hipofunkcije prethodno x-zracima ozračene hipofize na rast kraniofacijalnog i stomatognatnog sistema pacova. Metode. Primenjena doza x-zračenja od 27,92 Gy aplicirana je na dve grupe pacova u 8 seansi tokom perioda od 8 do 63 dana njihove starosti, uz praćenje efekata zračenja na rast kraniofacijalnog i stomatognatog sistema. U nameri da u merenju brojnih parametara pomenutih sistema razdvojimo efekte ozračene hipofize od direktnih efekata x zraka koje smo primenili na glavu, postavljen je eksperiment sa ozračivanjem glave dvema grupama životinja istim dozama x zraka, ali je jednoj zaštićena hipofiza olovnom pločicom postavljenom iznad hipofiza. Rezultati. Zaostajanje u rastu stomatognatog sistema kod pacova kojima je lokalno ozračena cela glava u odnosu na kontrolne životinje predstavlja zbirni efekat delovanja zračenjem izazvane hipofunkcije hipofize i direktnog delovanja x zračenja, dok zaostajanje u rastu stomatognatog sistema kod pacova sa ozračenom glavom i hipofizom zaštićenom od zračenja predstavlja isključivo efekat x zraka. Zaključak. Oštećenja stomatognatog i kraniofacijalnog sistema bila su veća kod životinja kojima hipofiza tokom zračenja glave nije bila zaštićena u odnosu na one sa zaštitom žlezde prilikom zračenja, pri čemu je rast kraniofacijalnog sistema u sagitalnom pravcu bio najviše pogođen. Veći zaostatak u rastu usled kombinovanoig dejstva hipofunkcije hipofize izazvane zračenjem i samog zračanje ustanovljen je na donjoj vilici u odnosu na gornju vilicu. Slično ovome, zao stajanje u rastu tibije bilo je izraženije kod životinja kojima tokom zračenja cele glave hipofiza nije bila zaštićena u odnosu na neštićene životinje.", publisher = "Savezno Ministarstvo Odbrane, Beograd", journal = "Vojnosanitetski pregled", title = "The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible, Uticaj eksperimentalno zračene hipofize na rast potkolenice, lobanje, gornje i donje vilice pacova", volume = "78", number = "9", pages = "964-972", doi = "10.2298/VSP190904005M" }
Milosavljević, Ž.,& Krstić, N.. (2021). The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible. in Vojnosanitetski pregled Savezno Ministarstvo Odbrane, Beograd., 78(9), 964-972. https://doi.org/10.2298/VSP190904005M
Milosavljević Ž, Krstić N. The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible. in Vojnosanitetski pregled. 2021;78(9):964-972. doi:10.2298/VSP190904005M .
Milosavljević, Željko, Krstić, Nikola, "The effects of experimentally irradiated pituitary gland on the growth of rats’ tibia, skull, maxilla and mandible" in Vojnosanitetski pregled, 78, no. 9 (2021):964-972, https://doi.org/10.2298/VSP190904005M . .