Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin
Patohistološke promene i stepen sanacionih procesa u jetri brojlera tretiranih T-2 toksinom
Апстракт
The 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were treated daily with T-2 toxin at 0.02 mg/kg BW for 7, 14 or 21 days respectively and a mixture of ethanol and physiological saline was administered to the control group of birds. Liver samples were taken after the period of toxin administration and the remaining birds from the control and experimental groups were normally fed and watered without toxin application until the end of the trial when liver samples were taken again. Histogenetic development of dystrophic and dyscyclic changes were found in the livers of the treated broilers. Morphological alterations of the liver were diverse in character, intensity and spread depending on the duration of exposure of broilers to the adverse effects of T-2 toxin, as well as the total quantity of toxin applied. The degree of the reparation varied depending on the duration of exposure t...o toxin, as well as the resting period. Evident reversible processes were found after short term exposure followed by a long resting period, while regeneration processes were not pronounced after chronic poisoning followed by a short resting period.
Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe Eksperimentalne grupe su svakodnevno tretirane T-2 toksinom u količini od 0.02 mg/kg TM tokom 7, 14 ili 21 dana, dok je brojlerima kontrolne grupe aplikovana smeša etanola i fiziološkog rastvora. Uzorci jetre za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci jetre ponovo uzeti. U jetri tretiranih brojlera utvrđen je histogenetski razvoj distrofičnih i discikličnih promena. Morfološke alteracije jetre razlikovale su se po karakteru, intenzitetu i raširenosti u zavisnosti od dužine ekspozicije brojlera, kao i od ukupne količine aplikovanog toksina. Stepen sanacionih procesa zavisio je od dužine ekspozicije brojlera, kao i od vremena oporavka. Reparacioni procesi su izraženi nakon kratkotrajnog delovanja T-2 toksina praćenog dugim periodom oporavka, dok se nakon hroničnog trovanja i kratkog vremena oporavka ne uočavaju r...egeneracioni procesi.
Кључне речи:
poultry T-2 toxin / pathomorphological alterations / reparatory processesИзвор:
Acta Veterinaria-Beograd, 2003, 53, 1, 27-34Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2298/AVB0301027S
ISSN: 0567-8315
WoS: 000181775800004
Scopus: 2-s2.0-0037255090
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Šefer, Dragan AU - Knežević, Milijana AU - Sinovec, Snežana M. AU - Sinovec, Zlatan PY - 2003 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/233 AB - The 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were treated daily with T-2 toxin at 0.02 mg/kg BW for 7, 14 or 21 days respectively and a mixture of ethanol and physiological saline was administered to the control group of birds. Liver samples were taken after the period of toxin administration and the remaining birds from the control and experimental groups were normally fed and watered without toxin application until the end of the trial when liver samples were taken again. Histogenetic development of dystrophic and dyscyclic changes were found in the livers of the treated broilers. Morphological alterations of the liver were diverse in character, intensity and spread depending on the duration of exposure of broilers to the adverse effects of T-2 toxin, as well as the total quantity of toxin applied. The degree of the reparation varied depending on the duration of exposure to toxin, as well as the resting period. Evident reversible processes were found after short term exposure followed by a long resting period, while regeneration processes were not pronounced after chronic poisoning followed by a short resting period. AB - Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe Eksperimentalne grupe su svakodnevno tretirane T-2 toksinom u količini od 0.02 mg/kg TM tokom 7, 14 ili 21 dana, dok je brojlerima kontrolne grupe aplikovana smeša etanola i fiziološkog rastvora. Uzorci jetre za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci jetre ponovo uzeti. U jetri tretiranih brojlera utvrđen je histogenetski razvoj distrofičnih i discikličnih promena. Morfološke alteracije jetre razlikovale su se po karakteru, intenzitetu i raširenosti u zavisnosti od dužine ekspozicije brojlera, kao i od ukupne količine aplikovanog toksina. Stepen sanacionih procesa zavisio je od dužine ekspozicije brojlera, kao i od vremena oporavka. Reparacioni procesi su izraženi nakon kratkotrajnog delovanja T-2 toksina praćenog dugim periodom oporavka, dok se nakon hroničnog trovanja i kratkog vremena oporavka ne uočavaju regeneracioni procesi. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin T1 - Patohistološke promene i stepen sanacionih procesa u jetri brojlera tretiranih T-2 toksinom VL - 53 IS - 1 SP - 27 EP - 34 DO - 10.2298/AVB0301027S ER -
@article{ author = "Šefer, Dragan and Knežević, Milijana and Sinovec, Snežana M. and Sinovec, Zlatan", year = "2003", abstract = "The 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 day pre-experimental period, the experimental groups were treated daily with T-2 toxin at 0.02 mg/kg BW for 7, 14 or 21 days respectively and a mixture of ethanol and physiological saline was administered to the control group of birds. Liver samples were taken after the period of toxin administration and the remaining birds from the control and experimental groups were normally fed and watered without toxin application until the end of the trial when liver samples were taken again. Histogenetic development of dystrophic and dyscyclic changes were found in the livers of the treated broilers. Morphological alterations of the liver were diverse in character, intensity and spread depending on the duration of exposure of broilers to the adverse effects of T-2 toxin, as well as the total quantity of toxin applied. The degree of the reparation varied depending on the duration of exposure to toxin, as well as the resting period. Evident reversible processes were found after short term exposure followed by a long resting period, while regeneration processes were not pronounced after chronic poisoning followed by a short resting period., Ogled je izveden na 48 Hybro brojlera podeljenih u četiri grupe Eksperimentalne grupe su svakodnevno tretirane T-2 toksinom u količini od 0.02 mg/kg TM tokom 7, 14 ili 21 dana, dok je brojlerima kontrolne grupe aplikovana smeša etanola i fiziološkog rastvora. Uzorci jetre za patohistološka ispitivanja uzeti su nakon završetka tretmana, a preostali brojleri su hranjeni i pojeni bez aplikacije toksina do 42. dana kada su uzorci jetre ponovo uzeti. U jetri tretiranih brojlera utvrđen je histogenetski razvoj distrofičnih i discikličnih promena. Morfološke alteracije jetre razlikovale su se po karakteru, intenzitetu i raširenosti u zavisnosti od dužine ekspozicije brojlera, kao i od ukupne količine aplikovanog toksina. Stepen sanacionih procesa zavisio je od dužine ekspozicije brojlera, kao i od vremena oporavka. Reparacioni procesi su izraženi nakon kratkotrajnog delovanja T-2 toksina praćenog dugim periodom oporavka, dok se nakon hroničnog trovanja i kratkog vremena oporavka ne uočavaju regeneracioni procesi.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin, Patohistološke promene i stepen sanacionih procesa u jetri brojlera tretiranih T-2 toksinom", volume = "53", number = "1", pages = "27-34", doi = "10.2298/AVB0301027S" }
Šefer, D., Knežević, M., Sinovec, S. M.,& Sinovec, Z.. (2003). Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 53(1), 27-34. https://doi.org/10.2298/AVB0301027S
Šefer D, Knežević M, Sinovec SM, Sinovec Z. Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin. in Acta Veterinaria-Beograd. 2003;53(1):27-34. doi:10.2298/AVB0301027S .
Šefer, Dragan, Knežević, Milijana, Sinovec, Snežana M., Sinovec, Zlatan, "Pathomorphological alterations and degree of reparatory processes in the liver of broilers treated with t-2 toxin" in Acta Veterinaria-Beograd, 53, no. 1 (2003):27-34, https://doi.org/10.2298/AVB0301027S . .