Toluene mediated oxidative stress and granulo-monocytopoiesis
Toluenom posredovani oksidativni stres i granulo-monocitopoeza
2003
Аутори
Božić, TatjanaStevanović, Jelka
Kovačević, Milica
Jović, Slavoljub
Lukić, Sanja
Petakov, Marijana
Borozan, Sunčica
Mijačević, Zora
Knežević, Milijana
Bulajić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The influence of toluene exposure on some biochemical and hematological parameters was investigated in adult female Wistar rats. The animals were subjected to intraperitoneal administration of toluene diluted in propylene glycol and the diluent alone for 3, 7 and 11 consecutive days at the same time intervals. The effects of toluene and propylene glycol were evaluated biochemically by determining the plasma concentrations of total proteins albumin and ceruloplasmin (Cp) together with erythrocyte malondialdehyde (MDA), and hematological indices from peripheral blood and bone marrow. The biochemical acute phase response was manifested by an elevated Cp concentration in all experimental animals. The markedly enhanced MDA concentration and statistically significant decrease in albumin level in toluene treated rats, indicated damage, to blood vessel endothelia. Alterations of leukocytes of peripheral blood and bone marrow (BM) granulocytic-monocytic progenitor cells were typical of an infla...mmatory response, with stimulation of granulo-monocytopoiesis. Therefore, it can be assumed that both toluene and propylene glycol mediated sterile peritonitis and oxidative stress injury, with changes intensified by toluene action.
U ovom ogledu je ispitivan efekat toluena na biohemijske i hematološke parametre odraslih ženki Wistar pacova. Životinjama je intraperitonealno davan rastvor toluena u propilen glikolu, kao i propilen glikol, jednom dnevno u trajanju od 3, 7 i 11 dana. Efekti davanih rastvora odredjivani su biohemijskim i hematološkim ispitivanjima plazme, krvi i punktata kostne srži. U plazmi pacova određivani su koncentracije ukupnih proteina, albumina kao i koncentracija eritrocitnog malondialdehida (RBC MDA). Biohemijske promene manifestovale su se hipoalbuminemijom, porastom koncentracije ceruloplazmina i visokom koncentracijom RBC MDA. Ovi nalazi ukazuju na oštećenje endotela krvnih sudova praćeno odgovorom akutne faze. Promene u broju leukocita periferne krvi kao i povećanje broja granulocitno-monocitnih (CFU-GM) progenitora kostne srži takođe su ukazali na tipičan proinflamatorni odgovor. Naši rezultati potvrđuju da toluen izaziva oksidativni stres i sterilni akutni peritonitis. Promene izazvan...e slobodnim radikalima kiseonika utiču i na odgovor progenitora kostne srži, pojavu koja do sada nije bila opisana.
Кључне речи:
rat / ceruloplasmin / hematological indices / malondialdehyde / propylene glycol / tolueneИзвор:
Acta Veterinaria-Beograd, 2003, 53, 4, 201-210Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
DOI: 10.2298/AVB0304201B
ISSN: 0567-8315
WoS: 000185850000001
Scopus: 2-s2.0-0242290349
Колекције
Институција/група
Fakultet veterinarske medicineTY - JOUR AU - Božić, Tatjana AU - Stevanović, Jelka AU - Kovačević, Milica AU - Jović, Slavoljub AU - Lukić, Sanja AU - Petakov, Marijana AU - Borozan, Sunčica AU - Mijačević, Zora AU - Knežević, Milijana AU - Bulajić, Snežana PY - 2003 UR - https://vet-erinar.vet.bg.ac.rs/handle/123456789/236 AB - The influence of toluene exposure on some biochemical and hematological parameters was investigated in adult female Wistar rats. The animals were subjected to intraperitoneal administration of toluene diluted in propylene glycol and the diluent alone for 3, 7 and 11 consecutive days at the same time intervals. The effects of toluene and propylene glycol were evaluated biochemically by determining the plasma concentrations of total proteins albumin and ceruloplasmin (Cp) together with erythrocyte malondialdehyde (MDA), and hematological indices from peripheral blood and bone marrow. The biochemical acute phase response was manifested by an elevated Cp concentration in all experimental animals. The markedly enhanced MDA concentration and statistically significant decrease in albumin level in toluene treated rats, indicated damage, to blood vessel endothelia. Alterations of leukocytes of peripheral blood and bone marrow (BM) granulocytic-monocytic progenitor cells were typical of an inflammatory response, with stimulation of granulo-monocytopoiesis. Therefore, it can be assumed that both toluene and propylene glycol mediated sterile peritonitis and oxidative stress injury, with changes intensified by toluene action. AB - U ovom ogledu je ispitivan efekat toluena na biohemijske i hematološke parametre odraslih ženki Wistar pacova. Životinjama je intraperitonealno davan rastvor toluena u propilen glikolu, kao i propilen glikol, jednom dnevno u trajanju od 3, 7 i 11 dana. Efekti davanih rastvora odredjivani su biohemijskim i hematološkim ispitivanjima plazme, krvi i punktata kostne srži. U plazmi pacova određivani su koncentracije ukupnih proteina, albumina kao i koncentracija eritrocitnog malondialdehida (RBC MDA). Biohemijske promene manifestovale su se hipoalbuminemijom, porastom koncentracije ceruloplazmina i visokom koncentracijom RBC MDA. Ovi nalazi ukazuju na oštećenje endotela krvnih sudova praćeno odgovorom akutne faze. Promene u broju leukocita periferne krvi kao i povećanje broja granulocitno-monocitnih (CFU-GM) progenitora kostne srži takođe su ukazali na tipičan proinflamatorni odgovor. Naši rezultati potvrđuju da toluen izaziva oksidativni stres i sterilni akutni peritonitis. Promene izazvane slobodnim radikalima kiseonika utiču i na odgovor progenitora kostne srži, pojavu koja do sada nije bila opisana. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Toluene mediated oxidative stress and granulo-monocytopoiesis T1 - Toluenom posredovani oksidativni stres i granulo-monocitopoeza VL - 53 IS - 4 SP - 201 EP - 210 DO - 10.2298/AVB0304201B ER -
@article{ author = "Božić, Tatjana and Stevanović, Jelka and Kovačević, Milica and Jović, Slavoljub and Lukić, Sanja and Petakov, Marijana and Borozan, Sunčica and Mijačević, Zora and Knežević, Milijana and Bulajić, Snežana", year = "2003", abstract = "The influence of toluene exposure on some biochemical and hematological parameters was investigated in adult female Wistar rats. The animals were subjected to intraperitoneal administration of toluene diluted in propylene glycol and the diluent alone for 3, 7 and 11 consecutive days at the same time intervals. The effects of toluene and propylene glycol were evaluated biochemically by determining the plasma concentrations of total proteins albumin and ceruloplasmin (Cp) together with erythrocyte malondialdehyde (MDA), and hematological indices from peripheral blood and bone marrow. The biochemical acute phase response was manifested by an elevated Cp concentration in all experimental animals. The markedly enhanced MDA concentration and statistically significant decrease in albumin level in toluene treated rats, indicated damage, to blood vessel endothelia. Alterations of leukocytes of peripheral blood and bone marrow (BM) granulocytic-monocytic progenitor cells were typical of an inflammatory response, with stimulation of granulo-monocytopoiesis. Therefore, it can be assumed that both toluene and propylene glycol mediated sterile peritonitis and oxidative stress injury, with changes intensified by toluene action., U ovom ogledu je ispitivan efekat toluena na biohemijske i hematološke parametre odraslih ženki Wistar pacova. Životinjama je intraperitonealno davan rastvor toluena u propilen glikolu, kao i propilen glikol, jednom dnevno u trajanju od 3, 7 i 11 dana. Efekti davanih rastvora odredjivani su biohemijskim i hematološkim ispitivanjima plazme, krvi i punktata kostne srži. U plazmi pacova određivani su koncentracije ukupnih proteina, albumina kao i koncentracija eritrocitnog malondialdehida (RBC MDA). Biohemijske promene manifestovale su se hipoalbuminemijom, porastom koncentracije ceruloplazmina i visokom koncentracijom RBC MDA. Ovi nalazi ukazuju na oštećenje endotela krvnih sudova praćeno odgovorom akutne faze. Promene u broju leukocita periferne krvi kao i povećanje broja granulocitno-monocitnih (CFU-GM) progenitora kostne srži takođe su ukazali na tipičan proinflamatorni odgovor. Naši rezultati potvrđuju da toluen izaziva oksidativni stres i sterilni akutni peritonitis. Promene izazvane slobodnim radikalima kiseonika utiču i na odgovor progenitora kostne srži, pojavu koja do sada nije bila opisana.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Toluene mediated oxidative stress and granulo-monocytopoiesis, Toluenom posredovani oksidativni stres i granulo-monocitopoeza", volume = "53", number = "4", pages = "201-210", doi = "10.2298/AVB0304201B" }
Božić, T., Stevanović, J., Kovačević, M., Jović, S., Lukić, S., Petakov, M., Borozan, S., Mijačević, Z., Knežević, M.,& Bulajić, S.. (2003). Toluene mediated oxidative stress and granulo-monocytopoiesis. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 53(4), 201-210. https://doi.org/10.2298/AVB0304201B
Božić T, Stevanović J, Kovačević M, Jović S, Lukić S, Petakov M, Borozan S, Mijačević Z, Knežević M, Bulajić S. Toluene mediated oxidative stress and granulo-monocytopoiesis. in Acta Veterinaria-Beograd. 2003;53(4):201-210. doi:10.2298/AVB0304201B .
Božić, Tatjana, Stevanović, Jelka, Kovačević, Milica, Jović, Slavoljub, Lukić, Sanja, Petakov, Marijana, Borozan, Sunčica, Mijačević, Zora, Knežević, Milijana, Bulajić, Snežana, "Toluene mediated oxidative stress and granulo-monocytopoiesis" in Acta Veterinaria-Beograd, 53, no. 4 (2003):201-210, https://doi.org/10.2298/AVB0304201B . .